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Explore the use of Raman to monitor a simple bioprocess, fermentation of glucose with yeast, qualitatively and quantitatively.

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The Cary 3500 UV-Vis systems use temperature-controlled UV-Vis spectroscopy to analyze molecules' thermal stability. They are essential for nucleic acid quantification quality control by measuring absorbance at 260 nm and performing thermal melt identification verification. Melting temperature (Tm) analysis is key for studying nucleic acid denaturation.

All starting materials, including APIs, must undergo analytical identity (ID) determination before pharmaceutical manufacturing to ensure drug safety. Oligonucleotides pose challenges for ID due to sequence specificity. Melting temperatures (Tm) combined with intact mass measurements offer a solution using UV-based spectrometry for precise Tm determination at Vetter Pharma.

Vetter Pharma successfully uses the Cary 3500 UV-Vis to optimize thermal melt measurements of oligonucleotide-based pharmaceuticals.