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A Q&A interview from SciX explored a porous-particle Raman platform became an alternative to SERS, and why AI could unlock biochemical meaning in vibrational spectra.

X-ray analytical techniques, spanning X-ray fluorescence (XRF), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS), are becoming faster, more portable, and more energy-efficient, with microbeam XRF spot sizes once exclusive to synchrotrons now available on laboratory benchtops.

Jürgen Popp, winner of this year’s Ellis R. Lippincott Award, discusses the regulatory, cost, and workflow hurdles of moving Raman spectroscopy into hospitals.

A recent conversation with Kevin Wilkinson, a professor of environmental chemistry at the Université de Montréal, sheds light on why no single signature can separate engineered nanoparticles from natural ones.

Top articles include the publication of a new terminology guide focused on data processing, machine learning, artificial intelligence (AI), and chemometrics.

This column shows that a Raman plate reader paired with partial least squares regression can simultaneously quantify glucose, fructose, sucrose, and ethanol in yeast fermentation samples, using turbidity-matched calibration standards to correct for yeast-induced turbidity, and offers a rapid, label-free, high-throughput method for tracking sugar consumption and ethanol production in strain screening, media optimization, and process development.

This column, the second installment on highly substituted benzene rings, shows that tri- and tetra-substituted substitution patterns can be distinguished by whether the ring-bending peak is present and by the position of the in-phase aryl C-H wagging peak, which shifts according to how many adjacent hydrogens the ring carries.

How do ions and water interact at the atomic level in nanochannels grafted with polymer brushes using all-atom molecular dynamics simulations? Siddhartha Das of the University of Maryland and his team are working on answering this question.

Mammograms can find breast microcalcifications but can’t tell whether they are likely benign or malignant.

Laser-induced breakdown spectroscopy (LIBS) is being used in numerous application areas, including environmental monitoring, cultural heritage, and space exploration.

At SciX, Kevin Wilkinson of the Universite de Montreal explains how faster data acquisition and new software have cut analysis time and how a particle’s chemical composition can link arsenic-bearing emissions back to a copper refinery’s processes.

Microspectroscopy, the marriage of spectroscopic chemical identification with microscopic spatial resolution, has advanced from Perkin-Elmer's first commercial infrared microspectrometer in 1953 to today's nanoscale AFM-IR probes, synchrotron-brightness infrared beamlines, and compact hyperspectral tissue imaging devices being developed for AI-assisted cancer detection.

Marc Porter describes how his group’s surface science work led to SERS-based immunoassays, why reproducibility and pre-analytics decide whether a test reaches the clinic, and the questions he still wants to answer.