Light is utilized in a wide range of spectroscopic techniques and practices to gain a variety of information about materials and chemicals. These analyses can include material/chemical identification, quantitative analysis, quality control/quality assurance testing, and biological studies, among other applications. Applications, along with sample handling for both FTIR and UV-Vis spectroscopy, will be outlined in this paper.
Oligonucleotide Analysis in Pharmaceutical Quality Control
January 14th 2025Melting point determination using ultraviolet-visible (UV-Vis) spectrophotometry can be used as a sequence-specific method for identifying therapeutic oligonucleotides in pharmaceutical quality control. This method offers a simple, highly selective approach to differentiate between isomers and ensure the integrity of oligonucleotide active pharmaceutical ingredients (APIs) and drug products.
The Optical Properties of Solid Samples
January 14th 2025Transmittance and reflectance measurements, which are useful for estimating the effects of various physical processes, can include thermal treatments, ionizing radiation exposure, optical exposure, and mechanical treatments—on both crystals and thin films.