Raman micro-spectroscopy is a powerful tool to identify the chemical nature of organic and inorganic materials with spatially down to about 1 μm chemical images show the distribution of individual components within heterogeneous materials.
Optimization of Thermal Stability Measurements for the Identification of Oligonucleotide APIs
December 19th 2024All starting materials, including APIs, must undergo analytical identity (ID) determination before pharmaceutical manufacturing to ensure drug safety. Oligonucleotides pose challenges for ID due to sequence specificity. Melting temperatures (Tm) combined with intact mass measurements offer a solution using UV-based spectrometry for precise Tm determination at Vetter Pharma.