The Cryo-Blade is an ultra high-capacity cryogenic grinder for comminution and processing capability up to 1 kg. The homogeneity of the sample is very efficient. Only 1 g is needed as a representative test sample from a 1 kg ground batch. The high-throughput capability saves valuable time for your laboratory and meets Food and Drug Administration (FDA) regulations. The Cryo-Blade automatically dispenses liquid nitrogen to allow the sample to reach cryogenic temperatures and then activates a grinding phase to pulverize samples, resulting in repeatable and reproducible sample preparation. No liquid nitrogen handling required. When liquid nitrogen is not desired or available, the unit can be used with dry ice to achieve desired results.