FTIR/NIR/Raman in Bio/Pharmaceutical Analysis

The C16767MA miniaturized ultraviolet (UV) spectrometer, developed by Hamamatsu, offers a groundbreaking solution for real-time, on-site water quality monitoring, replacing traditional, labor-intensive methods.

Melting point determination using ultraviolet-visible (UV-Vis) spectrophotometry can be used as a sequence-specific method for identifying therapeutic oligonucleotides in pharmaceutical quality control. This method offers a simple, highly selective approach to differentiate between isomers and ensure the integrity of oligonucleotide active pharmaceutical ingredients (APIs) and drug products.

Transmittance and reflectance measurements, which are useful for estimating the effects of various physical processes, can include thermal treatments, ionizing radiation exposure, optical exposure, and mechanical treatments—on both crystals and thin films.

Confocal Raman microscopy enables detailed and non-destructive analysis of semiconductors. In the video we present the application of confocal Raman microscopy to analyze material characteristics including doping, stress fields, crystallinity and warpage of a 150 mm (6 inch) silicon carbide (SiC) wafer. To maintain this nanoscale-precision across the macroscopically large x and y dimensions of an entire wafer, we used the WITec alpha300 Semiconductor Edition Raman microscope.

Modular Raman imaging microscopes provide a toolset for configuring experiments that can integrate complementary methods and evolve along with individual requirements. Following an introduction to the theoretical background, Dr. Ievgeniia Iermak will describe several of its variations including 3D Raman imaging and optical profilometry-guided measurements. Examples will be provided to demonstrate Raman imaging’s chemical acuity, high resolution, ease of use, and versatility for pharmaceutical research.

A focus on optimizing sample preparation in food and feed analysis can improve laboratory efficiency, data quality, and compliance with regulatory standards. Innovations like advanced microwave digestion and automated reagent handling can streamline workflows, improve safety, and ensure reliable analyses, ultimately supporting overall food safety.