This application note details the analysis of various brine solutions, containing up to 25% w/w dissolved salt, using robust ICP-MS instrumentation operated with the next generation Argon Gas Dilution (AGD) accessory. These high matrix samples were analyzed directly, without manual dilution, eliminating error prone and time- consuming preparation and handling steps. The developed method was rigorously tested for performance and reliability demonstrated through excellent quality control, matrix spike and internal standard recoveries for an analysis of 120 samples of 2.5% w/w brine solution.
Oligonucleotide Analysis in Pharmaceutical Quality Control
January 14th 2025Melting point determination using ultraviolet-visible (UV-Vis) spectrophotometry can be used as a sequence-specific method for identifying therapeutic oligonucleotides in pharmaceutical quality control. This method offers a simple, highly selective approach to differentiate between isomers and ensure the integrity of oligonucleotide active pharmaceutical ingredients (APIs) and drug products.
The Optical Properties of Solid Samples
January 14th 2025Transmittance and reflectance measurements, which are useful for estimating the effects of various physical processes, can include thermal treatments, ionizing radiation exposure, optical exposure, and mechanical treatments—on both crystals and thin films.
Streamlining Food & Feed Pre-Analytical Workflows for Metals and Fat Determination
January 8th 2025A focus on optimizing sample preparation in food and feed analysis can improve laboratory efficiency, data quality, and compliance with regulatory standards. Innovations like advanced microwave digestion and automated reagent handling can streamline workflows, improve safety, and ensure reliable analyses, ultimately supporting overall food safety.