X-Ray Fluorescence and the Pharmaceutical Industry: Implementing an Age-Old Technique
Wavelength-dispersive X-ray fluorescence (WDXRF) has for decades been widely implemented in quality control for many industries including, steel and alloy production, cement, plastics, glass, food, oil exploration and refining. It has been shown to be a highly stable, simple to operate, and reliable technique. In this podcast we will discuss the use of WDXRF, a direct analysis technique for the detection and quantification of elements/composition and elemental impurities in pharmaceuticals. On-going testing among various pharmaceutical companies has shown that it can be used to demonstrate compliance with regulations, such as ICH-Q3D and USP 232/233. However, this technique has not been fully exploited within this industry. Furthermore, we will discuss the ability to analyze final product as unadulterated pills in a non-destructive analysis.
Best of the Week: EAS Conference Coverage, IR Spectroscopy, Microplastics
November 22nd 2024Top articles published this week include highlights from the Eastern Analytical Symposium, a news article about the infrared (IR) spectroscopy market, and a couple of news articles recapping spectroscopic analysis of microplastics.
FT-IR Analysis of pH and Xylitol Driven Conformational Changes of Ovalbumin–Amide VI Band Study
November 21st 2024This study uses Fourier transform infrared (FT-IR) spectroscopy to analyze how the globular protein ovalbumin's secondary structures transition under varying pH conditions in the presence of the cosolvent xylitol, highlighting the role of noncovalent interactions in these conformational changes.
