A recent study used Raman spectroscopy to monitor cell culture processes.

A recent review article explored the Brazilian coffee industry and how spectroscopic- and chemometrics-based approaches are helping to ensure the authenticity and quality of Brazilian coffee.

Top articles published this week include a peer-reviewed article that discuss two multivariate calibration algorithms for the spectrophotometric analysis of a drug containing antazoline hydrochloride (AN) and naphazoline hydrochloride (NP), an article about chemometric calibrations, and a feature about the 2024 Emerging Leader in Molecular Spectroscopy awardee.

In the second installment of “The Big Review,” we discuss the physical mechanism behind how molecules absorb infrared (IR) radiation. Because light can be thought of as a wave or a particle, we have two equivalent pictures of IR absorbance. We also discuss the quantum mechanics behind IR absorbance, and how this leads to the different peak types observed in IR spectrum.

Data process mapping is an effective way to identify data integrity vulnerabilities and remediate them. A modified example published by the Active Pharmaceutical Ingredients Committee (APIC) is reviewed critically. Can it be simplified?

This study applied principal component regression (PCR) and partial least squares (PLS) algorithms for the spectrophotometric analysis of a drug containing antazoline hydrochloride (AN) and naphazoline hydrochloride (NP) without chemical separation. Both methods showed high accuracy and precision, with results closely matching those from a reference HPLC method, and were successfully validated for analyzing commercial pharmaceutical products.

As a preview to the SciX 2024 conference, Spectroscopy sat down with Ioan Notingher to discuss about what he is looking forward to at SciX 2024.

A recent study examines how Raman spectroscopy and UV-vis spectroscopy can be used in the quality control of over-the-counter medications (OTCMs), ensuring their authenticity.

This column is the continuation of our previous column that describes and explains some algorithms and data transforms beyond those most commonly used. We present and discuss algorithms that are rarely, if ever, seen or used in practice, despite that they have been proposed and described in the literature.

In this article, we introduce the concept of a gas exchange device (GED) and how it can be used to monitor organometallic compounds and metallic particles in specialty gases.

Researchers from the Shanghai Institute of Technology have developed a leading-edge method using surface-enhanced Raman scattering (SERS) to accurately differentiate between amino acid enantiomers. This breakthrough could revolutionize applications in pharmaceutical synthesis, disease diagnosis, and quality control of chiral compounds.

A recent study in Icarus examined how Mars’ ultraviolet radiation affects mineral composition on the planet’s surface.

Handheld instrumentation allows for on-site analysis without transporting samples to a laboratory, helping to reduce the cost and time of forensic investigations.

This year’s Emerging Leader in Molecular Spectroscopy Award recipient is Joseph P. Smith of Merck, whose research is significantly influencing pharmaceutical process development through his work in various spectroscopic techniques, biocatalysis, protein engineering, vaccine production, and advanced data analysis methods.

A recent study out of Russia examined the application of Raman spectroscopy in biomedical and biological research.