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In the past few years, Raman spectroscopy and its technological modifications—such as surface-enhanced Raman spectroscopy (SERS), coherent Raman scattering (CRS), and multimodal platforms—have transitioned from proof-of-concept demonstrations to impactful tools in biomedical research. These advances span therapeutic monitoring, chemical biology imaging, deep-tissue diagnostics, precision oncology, and multimodal analytics. This article synthesizes the most influential reviews in these areas, highlighting emerging trends, limitations, and future directions.

In an exclusive interview with Spectroscopy, John Margeson, a Product Manager at Thermo Fisher Scientific in the company’s Tewksbury headquarters, discusses the current state of handheld X-ray fluorescence (XRF) instrumentation.

Part II of our conversation with David Clases focused on his proof-of-concept analysis of microplastic and TiO₂ nanoparticles, and the new insights that emerged from simultaneously accessing size, molecular identity, and elemental composition at the single-particle level.

Returned samples from asteroid Bennu by the NASA OSIRIS-REx mission were analyzed using complementary spectroscopic and microspectroscopic techniques, including Fourier-transform infrared (FTIR) microscopy (μFTIR), scanning transmission X-ray microscopy (STXM), and secondary-ion mass spectrometry (SIMS), revealing a previously unknown polymeric organic phase enriched in nitrogen and oxygen. Spectroscopy spoke to Scott Sandford and Michel Nuevo of NASA’s Ames Research Center (Moffett Field, California), and Zack Gainsforth of the University of California’s Space Sciences Laboratory (Berkeley, California), three of the authors of the paper (1) resulting from the research team’s analysis.

Top articles published this week include several interviews from our ongoing coverage of the Winter Conference on Plasma Spectrochemistry and an inside look at an upcoming Pittcon 2026 symposium about generative AI.

In this video segment, Sarah Theiner explains why using LA-ICP-TOF-MS was the ideal technique for this research compared to more conventional methods. She also touches upon how the findings from her study could inform the design of future chemotherapies and combination treatments.

In this interview clip, David Clasas of the University of Graz discusses the trapping mechanism of the OF2i and how it improves downstream Raman and ICP-TOFMS measurements and also highlights the multimodal approach his team used to improve microplastic analysis.

In the final part of our conversation with Ken Marcus, he discusses how external acquisition systems enhance isotopic precision and what spectroscopic trends experts should be paying attention to in 2026.

In this “Pathways in Spectroscopy” episode, Sarah Theiner discusses what her career transition from research to sales was like, and how her experience at the University of Vienna prepared her for the rigors of her new role at Nu Instruments.

Specac Ltd, a global provider of spectroscopy accessories and sample preparation solutions, has announced the acquisition of Amax Precision Ltd, a Singapore-headquartered company that specializes in high-precision analytical instrument manufacturing.

In this video segment, Sarah Theiner dives into the research that she conducted at the University of Vienna, which focused on how chemoresistance affects drug distribution in the tumor microenvironment.

In the final part of our conversation with Martin Resano, he discusses how the use of partial least squares (PLS) regression improves the quality of the isotopic analysis data.