Fully Integrated Analysis of Metabolites, Impurities, and Degradants Using LC–NMR–MS
May 1st 2006Combining the three techniques of LC, MS, and NMR into one integrated system provides optimal use of NMR intrument time by using information-rich MS data to automatically guide the NMR operation. Here, the authors explore just this type of system.
In this article, the role of a triple-quadrupole mass spectrometer in performing in vitro studies of compound metabolic stability and identification of Phase I and II metabolites is demonstrated.