Spectroscopy in Pharmaceutical Analysis

The United States Pharmacopeia–National Formulary (USP–NF) has contributed to ensuring the quality of dietary supplements, foods, and medicines for more than 200 years. This overview explains the use of vibrational spectroscopy techniques in meeting USP–NF requirements and how the information is organized.

The accuracy of prediction models based on spectroscopic measurements can be influenced by a variety of factors, including aging equipment. Continuous monitoring is key to managing the PAT model lifecycle and ensuring that changes over time do not negatively affect prediction model performance.

The significance of the smaller spectral region of the Raman spectrum, defined as the “fingerprint in the fingerprint” region, cannot be overstated when it comes to active pharmaceutical ingredient identity testing (API).