Pittcon Review, Appendix V: Mass Spectrometry
Additional information from the mass spectrometry section of the Pittcon Review article.
Manufacturer: 1st Detect
Product name: MMS-1000
Product type: Mass spectrometer
For: Laboratory and process analysis
Portable: 6 x 12 x 8 in.
Accessories available: Preconcentrator, thermal desorber
Measurement mode: Ion trap
Special features: Affordable, small benchtop footprint, fast analysis, wide mass range, high sensitivity, high resolution
Suggested applications: Laboratory research, process control, pharmaceutical, petrochemical, teaching aid, classroom, food and beverage manufacturing, forensics
Primary benefits: Laboratory quality analysis
Manufacturer: Advion
Product name: Expression CMS
Compact Mass Spectrometer
Description: Personal single-pole quadrupole mass spectrometer, compact enough to operate in fume hoods and space-restricted laboratories
Manufacturer: Agilent Technologies
Product name: Agilent 8800 Triple Quadrupole ICP-MS (ICP-QQQ)
For: Laboratory analysis
Special features: The only triple-quadrupole ICP-MS system. The 8800 ICP-QQQ has higher sensitivity and lower backgrounds. This configuration enables MS-MS operation, providing precise control of reaction processes. MS-MS capability also enables several unique measurement modes and eliminates problematic interferences.
Software: 21CFR11 compliant, cGMP compliant, may be used in other equipment.
Suggested applications: Elemental analysis across all applications, low-level analysis of sulfur and phosphorus.
Unique features: Industry-leading matrix tolerance with Agilent's HMI technology; MS-MS capability permits controlled reaction chemistry
Manufacturer: Bruker Corporation
Product name: SCION TQ gas chromatograph–mass spectrometer
For: Laboratory analysis
New this year: Flow-through design, axial source, lens-free design, compound based scanning with MRM library, EDR detector
Special features: Increased robustness, reduced tuning and system maintenance, faster method development, increased dynamic range and reduced inter-scan delay.
Software: Available as separate product, 21CFR11 compliant, cGMP compliant, compatible with other manufacturers' equipment.
Primary benefits: Compound-based scanning, simplified set up, fast scanning, increased accuracy of assays, reduces tuning and maintenance of system.
Suggested applications: Food testing: pesticide residues and adulterants; priority pollutants: PCBs and PBBs; forensic/toxicology: drugs of abuse in hair; sports medicine: doping, steroids, or performance enhancing agents; sourcing of petroleum biomarkers
Manufacturer: Ionicon Analytik GmbH
Product name: High-Sensitivity PTR-QMS 500 mass spectrometer (PTR-MS, proton transfer reaction mass spectrometer)
New this year: Launch of new quadrupole-based series, completely reengineered instrument generation.
For: Laboratory and process analysis
Primary benefits: Detection limit < 1 pptv, ultra high sensitivity, response time down to 100 ms; measure with high resolution in real-time
Unique features: Analysis of entire mass range in a split second, no sample preparation necessary, direct air sampling.
Suggested applications: Low-concentration (pptv-range) volatile organic compounds (VOCs) for environmental research (atmospheric chemistry, BTEX, BVOC studies), food and flavor science (aroma, fragrance and flavor quantification), illicit substances and explosives detection.
Manufacturer: Ionicon Analytik GmbH
Product name: PTR-QMS 300 mass spectrometer
New this year: Updated software and solution portfolio based on the PTR-QMS 300 platform.
For: Laboratory and process analysis
Primary benefits: Small, lightweight, easily transportable, short start-up time and real-time VOC detection with a detection limit of < 0.5 ppbv
Unique features: Entire mass range analysis in split-second, no sample preparation necessary, direct air sampling.
Suggested applications: Process monitoring, mobile deployment, and customized monitoring solutions
Manufacturer: Ionicon Analytik GmbH
Product name: PTR-TOF 8000 mass spectrometer
For: Laboratory analysis
New this year: Improved sensitivity and detection limit by one order of magnitude.
Primary benefits: Mass resolution up to 8000, response time of 100 ms and detection limit in the single-digit pptv-range with a high resolution in real-time
Unique features: Separation of isobaric compounds, entire mass range analysis in a split second, no sample preparation necessary, direct air sampling.
Suggested applications: Low-concentration (pptv-range) volatile organic compounds (VOCs). Used in environmental research (atmospheric chemistry, BTEX, BVOC studies), food and flavor science (aroma, fragrance and flavor quantification), detection of illicit substances and explosives.
Manufacturer: Ionics
Product name: Triple Quadrupole MS
Description: Triple-Quadrupole GC–MS-MS system
Manufacturer: Livermore Instruments, Inc.
Product name: SPAMS 3.0
(single particle aerosol mass spectrometer)
For: Laboratory & Process
New this year: It is being made available to end-users.
Measurement mode: The SPAMS 3.0 draws in single particles, determines their size, and collects a dual-polarity mass spectrum from each individual one; measuring many per second in real time.
Special features: SPAMS instruments inherently can be used in the field.
Primary benefits: Can determine the size and chemical composition of aerosol particles and automatically interpret that data in real-time.
Unique features: A SPAMS 3.0 can process a range of particles sized from 100 nm to 30 μm.
Manufacturer: nanoLiter, LLC
Product name: nanoLiter Cool Wave X
Mass spectrometer and other sample input, placement device.
For: Laboratory and Process analysis
Description: Can print liquids for MS or ATIR, other.
Special features: Transfers 100% of liquid samples into mass spectrometers or other instruments.
Software:21CFR11 compliant, cGMP compliant, may be used in other equipment, Compatible with other manufacturers' equipment
Suggested applications: Mass spectrometry, ESI proteomics, MALDI bacteria characterizations per NIH work, SIMS, LDI, DART, and DESI.
Primary benefits: 10–100X increase in sensitivity, allows making spatially tight concentrations of depositions for ATIR and other forms of spectroscopy including MALDI, SIMS, DART and DESI.
Manufacturer: Netzsch Instruments North America, LLC
www.netzsch-thermal-analysis.com
Product name: STA-GC-MS
GC–MS system coupled to simultaneous TGA-DSC
For: laboratory analysis
New this year: Thermo gravimetric analyzer connected to GC–MS
Suggested applications: Evolved gas analysis of polymers, pharmaceuticals, and foods
Primary benefits: Separation of compounds in evolved gas prior to analysis with MS
Unique features: TGA of TG-GC–MS system can be equipped with automatic sample changer.
Manufacturer: Thermo Fisher Scientific
Product name: Thermo Scientific iCAP Q ICP-MS
For: Lab analysis
New this year: User-inspired design, interference removal technology, increased throughput, robust
Accessory/component: Autosampler enclosure, LC/IC/GC coupling, autosamplers and others
Measurement mode: Mass spectrometry
Suggested applications: Environment, food safety, semiconductor, pharma, reasearch, geochem
Primary benefits: Ease of use, throughput, performance, reliability
Unique features: New skimmer cone insert technology, QCell collision cell with flatapole technology
Manufacturer: Waters Corporation
Product name: Waters SQ Detector 2
Single-quadrupole MS detector
For: Lab analysis
New this year: The SQ Detector 2 is Waters' newest single-quadrupole mass detector.
Description: Wide mass range (3000 m/z), 15000 Da/s scan speed, compatible with the Waters Universal Ionization Source platform, UPLC, HPLC, GC, preparative HPLC, and Waters UPC2, ZSpray technology
Accessory/component: wide range of ionization modes including ESI, APCI, ESCi, nanoFlow ESI, TRIZAIC, ASAP, APPI and APGC, DESI, DART, and LDTD.
Measurement mode: Typically used as an LC–MS system and autopurification system
Special features: Ease of use, robustness and reliability, versatility, designed for compatibility with chromatographic and nonchromatographic analyses.
Software: MassLynx MS software, available as separate product, 21CFR11-compliant ready, cGMP compliant ready,
Suggested applications: Routine qualitative and quantitative applications within the pharmaceutical, chemical materials, food safety and environmental industries for both small and large molecule applications.
Primary benefits: a mass detection system that is easy to use and gives consistent, reliable results.
Unique features: Enables LC–MS, SFC–MS, GC–MS, and direct sample analysis
Manufacturer: Waters Corporation
Product name: Waters Synapt G2-S high-definition MS system
Hybrid orthogonal acceleration time-of-flight mass spectrometer
For: Lab analysis
New this year: Has both StepWave ion transfer optics and Triwave ion mobility technologies
Special features: 30X improvement in signal intensity, 5X improvement in signal-to-noise, and 10-fold improvement in limits of quantitation over previous-generation mass spectrometers. Combines high-resolution MS-MS with high-efficiency ion-mobility spectroscopy.
Accessory/Component: High-Definition MSE acquisition method in proteomics studies, five orders of magnitude dynamic range.
Suggested applications: Proteomics, metabolomics, lipidomics, drug discovery and development, polymers, petrols, imaging, food and environmental studies, biomarker discovery.
Unique features: Comprehensive MSE data acquisition, T-wave ion mobility separations,
Manufacturer: Waters Corporation
Product name: Waters Xevo TQD
Tandem quadrupole mass spectrometer for routine quantitative LC–MS-MS analyses.
For: Lab applications
New this year: This is the newest addition to Waters' Xevo family of tandem quadrupole mass spectrometers
Accessory/component: Wide range of ionization modes: ESI, APCI, ESCi, nanoFlow ESI, TRIZAIC, ASAP, APPI, and APGC.
Description: Typically used as a UPLC–MS-MS system
Special features: TQD features RADAR technology. RADAR technology is a data acquisition approach that allows scientists to monitor for matrix interferences, metabolites, impurities, and degradants in their samples while accurately quantifying their target compounds.
Software: MassLynx MS software
21CFR11-compliant ready, cGMP-compliant ready,
Suggested applications: Routine quantitative applications, robustness, reliability, and ease of use are the primary objectives. Many of these applications are within the chemical materials, environmental, food safety, and pharmaceutical industries.
Unique features: Collision cell technology, Rapid polarity switching
