Raman spectroscopy has been utilized in the pharmaceutical community for years. Raman works best for raw material identification, polymorphic studies and high throughput screening. However, many active ingredients exhibit fluorescence precluding the use of Raman. A new hand-held Raman spectrometer is now available for users to analyze samples utilizing new patented fluorescence mitigation methods. This new spectrometer has a wide spectra range, high spectral quality for optimizing the analysis, resulting in virtual elimination of false positive/false negative test results.