Application Notes

Renishaw’s RA802 Pharmaceutical Analyser was used to detect small amounts of different polymorphic forms of an active pharmaceutical ingredient in a generic drug powder.

Thanks to rapid technology advancements in recent years, Raman Spectroscopy has become a routine, cost-efficient, and much appreciated analytical tool with applications in material science and in-line process control for pharmaceutical, food & beverage, chemical and agricultural industries. Improvements in laser technology, detectors (CCDs and InGaAs arrays), and spectral filters (VBG-based notch filters), along with developments of new schemes for signal generation and detection, have aided Raman instrument manufacturers in overcoming the challenge of weak signals which has accelerated instrument development and market growth. In this white paper, we discuss important performance parameters to consider when selecting the laser for Raman spectroscopy experiments.

This application note demonstrates analysis of elemental impurities, such as arsenic, in vitamin B12 according to USP chapter , using triple quadrupole ICP-MS.

Application note showing how a photoluminescence spectrometer was used to examine the photoluminescence spectroscopy of carbon dots.

Glass Expansion’s new HydraMist spray chamber can be simultaneously used to determine As, Se, Sb and Hg via hydride generation, in addition to the determination of non-hydride forming elements using conventional pneumatic nebulization. The performance of the HydraMist was evaluated on an Agilent 5100 SVDV ICP-OES, and, when paired with a SeaSpray nebulizer, the detection limits for the hydride forming elements were improved between 15- and 50-fold without compromising the analytical performance of the non-hydride forming elements.

This application note demonstrates how the PlasmaQuant MS provides low detection limits, accurate results and long-term stability analyzing volatile solvents.

Background correction is a critical part of any spectrometric analysis, but how much can you trust it? In this ebook, learn about traditional correction methods as well as a better way for background correction.

• QuEChERS vs. a modified method with the Geno/Grinder for pesticide analysis • Stable isotope analysis for the testing of food product origins • Arsenic testing in hard ciders

Mercury is a persistent pollutant often exacerbated by human activities. A historical but pertinent case of effects of industrial pollution on the human population in Minimata, Japan is reviewed.

The photopolymerization curing process of a UV-curable photopolymer was investigated using time-resolved Attenuated Total Reflection spectroscopy.

Raman-based polymer process monitoring enables rapid optimization of polymerization conditions, improves process efficiency, and ensures optimal final form.

• Achieving low detection limits by minimizing contamination in sample prep • Economic approach to reducing reagent blanks in ICP-OES and ICP-MS • Automated acid reflux cleaning system for maximum efficiency

• How to balance compliance needs with creating useful SOPs. • Tips and tricks for ensuring consistency. • Why and how you should test your SOPs

As synthetic opioid overdose deaths continues to rise, the use of fentanyl and its analogues in legacy drugs are posing significant danger to communities and first responders. This application note describes the use of the Rigaku ResQ CQL 1064nm handheld Raman analyzer to provide both bulk and trace analysis of fentanyl and other narcotics.

Reliable TOC analysis using the NPOC method with TIC control, high throughput by parallel purge and analysis, comparing catalytic combustion with UV-chemical oxidation.

This note looks at incidences of polymorphism in drug development including advantages and challenges.

This study shows Raman imaging, atomic force microscopy and scanning near-field optical microscopy characterizing and depth-profiling polymer blends and layers.

This industry report describes how the DMA-80 evo provides fast and accurate results for the analysis of mercury in nutraceutical samples without any sample prep.

This industry report describes how the DMA-80 evo can analyze as soils, sludges, and wastewater under EPA method 7473 without any wet chemistry sample prep in only 5 min.

This report shows how direct mercury analysis is used in the cement industry for testing raw materials prior to kiln combustion to control for Hg emissions.

Learn how Direct Mercury Analysis by thermal decomposition and amalgamation provides an accurate and easy to use technique that overcomes the limitations of ICP-MS.

This industry report describes how the DMA-80 evo can be used to determine mercury in coal samples in compliance with ASTM method 6722-01.

Mercury content in fish is an environmental and food safety concern. Learn how fish tissue analysis is performed with no sample prep using the DMA-80 evo.

This application note demonstrates the routine automated multi-element analysis of environmental samples using triple quadrupole ICP-MS.

• Raman spectroscopy of streamlining pharma QC and formulation development • Implementing transmission Raman for fast content uniformity testing • Through-container identity verification of polysorbates 20, 40, 60, and 80

• Even with a relatively light sample load of 250 samples per week, remeasuring 15% of them adds up to 2 weeks per year. • That’s 2 weeks you could be using for something more value-adding (and less boring).

This industry report describes how the Milestone ultraWAVE can process large, dissimilar and difficult pharmaceutical samples quickly and easily – all without batching.

Analysis of fertilizer products gives the ratio of macronutrients, which must be correct to ensure optimal efficacy. Learn how the ETHOS UP can process highly reactive fertilizer samples, even in large sample amounts.

Many polymers are very stable and require high temperatures and pressures to completely digest. Learn how the ultraWAVE can process these samples quickly and easily, yielding superior analytical data.