Safwan M. Obeidat

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Spectrophotometric and Chemometric Methods for Simultaneous Determination of Antazoline and Naphazoline in Pharmaceutical Eye Drops

Safwan M. Obeidat;Idrees F. Al Momani
October 9th 2024

This study applied principal component regression (PCR) and partial least squares (PLS) algorithms for the spectrophotometric analysis of a drug containing antazoline hydrochloride (AN) and naphazoline hydrochloride (NP) without chemical separation. Both methods showed high accuracy and precision, with results closely matching those from a reference HPLC method, and were successfully validated for analyzing commercial pharmaceutical products.

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