Improving Sensitivity and Selectivity in Pesticide Analysis with GC–MS and GC–MS-MS
Spectroscopy E-Books
The selection of analytical methods for gas chromatography (GC)-amenable pesticides is often based on requirements for sensitivity and selectivity for regulatory needs or other monitoring requirements. Methods with both electron ionization (EI) and negative chemical ionization (NCI) are often required to cover the full range of GC–amenable pesticides at trace levels. Pesticides fragment easily in EI and CI sources such that the molecular ion is often low in abundance. NCI can provide added selectivity and sensitivity over EI methods. NCI is most commonly used in selected-ion monitoring mode. The lack of availability of parent ions for collision-induced dissociation for tandem mass spectrometry (MS) can limit the feasibility of GC–MS-MS for pesticides that significantly fragment in the ion source. Options for improving sensitivity by using of large-volume cold on column or programmable temperature vaporizer injections are presented. Read more
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Best of the Week: What You Missed from Pittcon and AAFS
March 14th 2025Top articles published this week include a video interview on the role of near-infrared (NIR) spectroscopy in food and bioanalysis, a recap of an important session at Pittcon, and a dynamic video that summarizes the highlights of the American Academy of Forensic Sciences (AAFS) Conference.
New Fluorescence Model Enhances Aflatoxin Detection in Vegetable Oils
March 12th 2025A research team from Nanjing University of Finance and Economics has developed a new analytical model using fluorescence spectroscopy and neural networks to improve the detection of aflatoxin B1 (AFB1) in vegetable oils. The model effectively restores AFB1’s intrinsic fluorescence by accounting for absorption and scattering interferences from oil matrices, enhancing the accuracy and efficiency for food safety testing.
