Product Resources
Thermo Fisher Scientific's LTQ Orbitrap XL mass spectrometer is designed for protein identification and biomarker discovery. The instrument reportedly features high sensitivity in MS and MSn, a rapid scan rate, high mass accuracy, and up to 100K resolution power. According to the company, the product includes an octapole collision cell for increased flexibility in MS-MS fragmentation applications such as peptide quantitation, PTM analysis, de novo sequencing, and metabolomics research. Thermo Fisher Scientific, Waltham, MA;
Mass spectrometer
Thermo Fisher Scientific's LTQ Orbitrap XL mass spectrometer is designed for protein identification and biomarker discovery. The instrument reportedly features high sensitivity in MS and MSn, a rapid scan rate, high mass accuracy, and up to 100K resolution power. According to the company, the product includes an octapole collision cell for increased flexibility in MS-MS fragmentation applications such as peptide quantitation, PTM analysis, de novo sequencing, and metabolomics research. Thermo Fisher Scientific, Waltham, MA;
MS software
Applied Biosystems has released their LightSight Software Version 2.0 for metabolite identification, designed to enable pharmaceutical companies and contract research organizations to screen drug candidates more quickly and accurately. According to the company, the software provides efficient workflows to identify and confirm metabolites from data acquired on Applied Biosystems/MDS SCIEX's triple quadrupole and linear ion trap mass spectrometers. Applied Biosystems, Foster City, CA,
TOF MS
Hitachi's NanoFrontier with TOF MS is designed for preserving posttranslational modifications (PTM) with electron capture dissociation (ECD), which allows definitive PTM site and type determinations. According to the company, the product provides high-throughput intelligent control of combined ECD and CID scans for interrogation of modified proteins. Hitachi High Technologies America, San Jose, CA;
Mass spectrometer
Bruker Daltonics introduces the apex-ultra FTMS mass spectrometer, which reportedly features a wide dynamic range, high resolving power, high mass accuracy, and fast data acquisition. According to the company, the product is designed for top-down proteomics and the analysis of complex mixtures in applications such as metabolomics or petroleomics. Bruker Daltonics, Billerica, MA;
Portable GC-TMS system
The Guardion-7 portable GC–MS system by Torion features a low-thermal-mass capillary gas chromatograph with ballistic temperature programming and a miniature torodial ion trap mass spectrometer with a mass range of 50 to 500 Daltons. According to the company, the system is totally self-contained, hand-portable, battery operated, and weighs less than 28 pounds. Torion Technologies, Inc., Pleasant Grove, UT;
ICP Emission spectrometer
Shimadzu's ICPE-9000 Multitype ICP Emission Spectrometer is designed to analyze substances ranging from metals to pharmaceuticals. The product's vacuum spectrometer is equipped with semiconductor detectors as well as mini-torch technology, which reportedly reduces argon gas consumption. Shimadzu Scientific Instruments, Columbia, MD;
MS scanning option
Varian, Inc. announces the TurboDDS, their new data dependent scanning option for the 500-MS Ion Trap Mass Spectrometer, designed to deliver complex tandem mass spectrometry (MS-MS) or MSn measurements automatically, based on limited and simple operator specified criteria. According to the company, the product Complex sequences of mass spectrometric measurements can be accomplished in a single chromatographic separation. Varian, Inc., Palo Alto, CA;
Ion sources
Prosolia's Omni Spray Ion sources are a series of ionization sources based on desorption electrospray ionization (DESI). DESI is a simple, sensitive, gentle, and versatile ionization method that allows for the direct and rapid sampling of surfaces without any sample preparation and under ambient temperature and pressure conditions. According to the company, with this source, scientists are able to analyze both large and small molecules from a variety of surfaces. Prosolia, Inc., Indianapolis, IN; www.prosolia.com
UV-vis spectrophotometers
Hitachi introduces two new UV-Visible models: the U-3900 (single monochromator) and U-3900H (double monochromator). The products are designed to offer high-performance specifications and functionality for a wide range of applications in the environmental, food, biotech, pharma, and chemical industries, as well as material sciences, for liquid and solid sample measurements. Hitachi High Technologies America, San Jose, CA;
Mass spectrometers
Agilent's 6100 series single-quadrupole mass spectrometers are designed to obtain high-quality MS data across chromatographic peaks with widths as narrow as 1 s. According to the company, the systems provide maximum spectral information confirming that the correct peaks are being identified and faster POS/NEG mode switching. Agilent Technologies Inc., Wilmington, DE;
LC–MS solvents
Mallinckrodt Baker's J.T.Baker LC-MS laboratory solvents and solvent blends are designed for use in pharmaceutical, biotechnology, environmental, and food and beverage analyses. According to the company, these solvents are filtered through a 0.2-μm filter to remove particles and reduce contaminants. The solvents reportedly are function-tested for LC-UV detection and LC–MS applications. The solvents are available in quantities ranging from 1 L to mini bulk volumes. Mallinckrodt Baker, Inc., Phillipsburg, NJ.
HPLC columns
INERTSIL ODS-EP columns are designed to provide excellent peak shape, durability, and selectivity for both acids and bases. The columns reportedly are highly stable to acidic pH. GL Sciences, Inc., Torrance, CA;
LC–MS system
Shimadzu's LC-MS-IT-TOF LC-MS system features Formula Predictor software, which reportedly takes advantage of multiple levels of fragmentation, isotope pattern verification, and unique fragment-ion filtering techniques to determine the correct formula for unknown components. According to the company, the system addresses the needs of biomarker discovery, trace amount impurity identification, and natural products research. Shimadzu Scientific Instruments, Columbia, MD;
Desalting well plate
Orochem's Coral 96-well desalt spin plate reportedly contains desalting resin that provides >95% retention of the salts. The plates are designed for processing compounds with masses greater than 7000 Da. According to the company, samples of 20–100 μL in the well plate can be desalted in 5 min in preparation for downstream analyses such as mass spectrometry, capillary electrophoresis, and metabolite screening. Orochem Technologies Inc., Lombard, IL;
