Mallikarjun Narayanam

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Applications of Raman Spectroscopy in Solvent Distillation and Exchange During Early-Phase Chemical Synthesis

Ravikumar Ramachandran;Mallikarjun Narayanam;Robert Wethman;Karthik Jayaraman;Amol G. Dikundwar;Hemant Bhutani

May 1st 2022

The case studies presented here successfully demonstrate the use of inline Raman spectroscopic analysis to estimate solvent content during the solvent exchange and distillation operations in the synthesis of active pharmaceutical ingredients.

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