Application Notes

The Agilent Multimode Sample Introduction System (MSIS) is an innovative option for both PerkinElmer Optima ICP-OES instruments and Agilent ICP-OES and Agilent MP-AES instruments. In this application note, we will show you how MSIS could help saves set-up and analysis time and also keep the lab as productive as possible.

The Milestone UltraWAVE can digest up to 22 different sample types simultaneously. The high temperature and pressure capability enables a complete digestion of nearly all inorganic sample types that need to be analyzed for trace metals.

Spectral Systems has developed Beamsplitter coating designs which offer the highest performance and eliminates undesirable spectral features.

Raman spectroscopy was used to control a semi-batch polymerization reaction. Kaiser Raman data enabled open-loop and closed-loop feedback control, allowing production of materials with consistent quality.

There is a need to optically characterize even smaller components and materials; placing these items in the standard UV-Vis sample compartment can be challenging. This note describes how very small samples can be routinely, accurately, and successfully characterized using UV-Vis combined with a standard optical microscope.

In this application note, we demonstrate the power of the modular spectroscopy to measure the UV-Vis absorbance of natural and artificial colorants used in sports drinks.

Reuse of fracking fluid is contingent on chemical and physical properties, which in turn are related to the chemical composition of the water. Waste water from fracking wells generally has high total solids content often in concert with salts, organic chemicals, metals and naturally-occurring radioactive materials. Often, the water must undergo a cleaning or dilution step before reuse or discharge. An online monitor for high levels of sulfate could be one component of an on-line recycling system of water in hydraulic fracturing processes and this study looks at Raman spectroscopy as a potential measurement technique for such a monitor.

Mass Spectrometric Imaging (MSI) using DESI provides molecular imaging without the interference of the matrix required for MALDI and offers the advantage of preserving sample for further analysis. DESI coupled to High Resolution Accurate Mass (HRAM), is shown here to elucidate spatial distribution of lipids, protein, and metabolites in tissue sections and can provide confident and discriminate biomarker determinations.

In this application note, we evaluate sunscreen samples using spectroscopy. The same experimental setup can measure the SPF of fabrics and other materials, demonstrating how modular spectrometers can measure samples relevant to health.

Milestone’s DMA-80 provides a highly flexible platform with an extremely wide dynamic detection range to analyze coal samples with varying mercury levels.

PLIF, PIV and next generation imaging detectors - Combustion processes, if uncontrolled, are inherently inefficient and increasing the efficiency of combustion in engines, gas burners and furnaces is a significant challenge for the future due to limited fossil fuel resources and their effects on the environment.

Handheld Raman spectrometers are now designed and built for practical everyday use in a vast array of applications. The new BRAVO by Bruker takes handheld Raman Spectroscopy to a new level, overcoming the limitations of previously available systems such as limited wavelength accuracy, non-safe laser usage and fluorescence interference. Now with BRAVO wavelength accuracy is significantly better than competitive devices resulting in the highest data consistency and the BRAVO incorporates new technology called Sequentially Shifted Excitation (SSE™) to mitigate fluorescence.

The Diablo 5000A RTGA-MS allows the process stream to be seen in real-time and provides quantitative data with reliable mass information. The result is visualization.

This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection.

A wireless NIR spectrometer is deployed on solid dose blending formulation for end-point monitoring. The MicroNIR PAT is democratizing the use NIR spectroscopy in pharmaceutical manufacturing facilitating Quality by Design (QbD) adoption.

This application note demonstrates the effectiveness of Agilent compact and portable FTIR systems for detecting counterfeit pharmaceuticals with three examples: ethambutol hydrochloride, cephuroxime axetil, and atorvastatin calcium.

This technical note describes features and functionality of Agilent MicroLab software (version 5.2 and later) in combination with SCM and SDA for data management and electronic traceability, which enable customers to implement the guidelines of 21 CFR Part 11.

This note highlights OpenLAB ECM Compliance Pack for UV-Vis Benefits such as efficient data storage and retrieval, security, data integrity and traceability, and 21 CFR Part II Comliance.

This note looks at specific components that require validation; the instrument, software, and validated test methods, and describes the features of the Agilent Cary 8454 UV-Visible system that is designed to meet the requirements of both initial and recurrent validation.

This note describes how the design of the Cary 8454 UV-Vis exceeds performance requirements stipulated by global pharmacopeia guidelines including USP and EP/BP. Configured for compliance, with 21 CFR Part 11, the instrument performs multi wavelength analysis, time-based kinetics assays, and routine QA/QC measurements.

This application note demonstrates how Agilent’s Cary 630 FTIR easily meets the specifications of the US, European, Japanese, Chinese, Indian and International Pharmacopoeia. Its combination of compact size, design, intuitive and regulation-compliant software makes the Cary 630 FTIR an ideal instrument for pharmaceutical quality control.

The Agilent Cary 8454 UV-Visible system is ideal for regulatory Pharma QA/QC applications, and can acquire a complete spectrum in less than 1 second. This technical note outlines both applications-based and technical considerations for choosing a diode array UV-Vis

This application note describes a very sensitive classification method, partial least squares–discriminant analysis (PLS-DA), incorporated in Agilent innovative MicroLab software, to classify and qualify materials of interest with greater sensitivity and specificity than possible with simple library search methods.

The ability to easily characterize thin films by variable angle transmission and reflection is very important in both the design/development process and in the final production. This note presents the use of UV-Vis-NIR spectroscopy to characterize film samples in the full spectral region, from UV to NIR.

Photoluminescence (PL) lifetime measurements in NIR are the key parameters in assessing the optical efficiency of devices involving lanthanides, as well as in quality control during their manufacturing.

This application note describes the measurement of food macronutrients by diamond attenuated total reflectance (ATR) mid infrared spectroscopy. Specific examples include the measurement of sugar content of grapes (grape juice) and the measurement of fats in cheese, chocolate and milk.

Miniature X-ray sources reached the development level that is appropriate for their use in the handheld and portable X-Ray diffraction (XRD) instruments. This note describes the application of X-ray sources for the residual stress measurements using XRD.