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Latest:
Determination of Recombinant Monoclonal Antibodies and Noncovalent Antigen TNFa Trimer Using Q-TOF Mass Spectrometry (PDF)This article discusses how quadrupole time-of-flight mass spectrometry was used to measure the intact molecular weights of large proteins and some noncovalent protein complexes.
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Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
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IMS for Cleaning Verification (PDF)The need to verify cleaning between manufacturing runs presents a special challenge to the analytical chemist. In this article, the principles of ion mobility spectrometry are described, its performance is compared to HPLC for the analysis of cleaning validation samples, and findings are presented from a study to establish the feasibility of using IMS in validating a cleaning verification method.
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Test of an In Vivo Method to Detect Chloroplast Division in Crop Plants, Part III: Statistical Proofs of Observation and General Utility of the Method (PDF)This article is the third installment in a series about a novel spectrofluorometric method that allow for in vivo observation of the division of chlorplast populations in leaves of Arabidopsis thalania.
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Sampling Accessories for the High-Throughput Analysis of Combinatorial Libraries Using Spectral Imaging (PDF)This article describes several sampling accessories, designed by the authors, that allow a variety of combinatorial systems to be analyzed.
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Raman Spectroscopy for Homeland Defense Applications (PDF)Raman spectroscopy is used routinely by the agencies tasked with homeland defense, and current research using surface enhanced Raman spectroscopy shows promise for the detection of chemical warfare agents and other toxic chemicals. This article overviews some of the latest developments in the field.
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Photonic Bandgap Fibers in Gas DetectionPhotonic crystal fibers are novel optical waveguides that offer promising alternatives for various sensing applications. This article describes an experiment in which the absorption spectrum of acetylene was measured to demonstrate the effectiveness of photonic bandgap fibers for high sensitivity gas detection. Methane also was studied to determine the same capability in weakly absorbing gases.
Latest:
Test of an In Vivo Method to Detect Chloroplast Division in Crop Plants, Part II: Verification of the Phenomenon by Germplasm Methods and Confocal Microscopy (PDF)Part two of a series about a novel spectrofluorometric method that allows for in vivo observation of division of chloroplast populations in leaves of Arabidopsis thaliana.
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Using Dynamic Reaction Cell ICP-MS to Determine the Full Suite of Elements in Rainwater Samples (PDF)This paper describes how analysts at an environmental and geochemical laboratory utilize dynamic reaction cell ICP-MS technology to study the transport and deposition of important trace metals from rainwater.
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Analysis of Fusarium Toxins Using LC?MS-MS (PDF)The authors present an MS technique that reliably detects several types of fungal mycotoxins, and compare electrospray ionization and atmospheric chemical ionization techniques.
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Tutorial: Attenuation of X-Rays By MatterIn this X-ray tutorial, the authors attempt to answer the frequently asked question, "How deep do the X-rays penetrate my sample?"
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Analysis of Fusarium Toxins Using LC?MS-MS (PDF)The authors present an MS technique that reliably detects several types of fungal mycotoxins, and compare electrospray ionization and atmospheric chemical ionization techniques.
Latest:
Photonic Bandgap Fibers in Gas DetectionPhotonic crystal fibers are novel optical waveguides that offer promising alternatives for various sensing applications. This article describes an experiment in which the absorption spectrum of acetylene was measured to demonstrate the effectiveness of photonic bandgap fibers for high sensitivity gas detection. Methane also was studied to determine the same capability in weakly absorbing gases.
Latest:
Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
Latest:
Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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SERS Nanosensors for Biomedical Applications—from Cancer Diagnoses to Characterizing Drug Delivery Nanocarriers***Live: Tuesday, November 24, 2020 at 11am EST | 8am PST | 4pm GMT | 5pm CET *** Join us for this webcast on surface enhanced Raman scattering (SERS) applications in the biomedical field. Learn how biofunctionalized metal nanoparticles can act as bright nanosensors, providing diagnostic information on biosystems, selectively targeting cancer cells and probing pH with very high spatial resolution. *** On demand available after final airing until Nov. 24, 2021.***
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Mass Spectrometry in Analytical LipidomicsAn overview on the present state of analytical lipidomics is presented from the perspective of mass spectrometry (MS) and the MS strategies most frequently used in lipidomics are highlighted.
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Multi-Residue Pesticide Analysis Using a GC Triple Quadrupole Mass SpectrometerThere are currently more than 1000 pesticides in use worldwide in the production of foodstuffs. There is a significant risk to human health and the environment due to increased pesticide use, poor agricultural practices and illegal use.
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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High-Throughput Quantitative Analysis of Vitamin D Using a Multiple Parallel LC–MS System Combined with Integrated On-Line SPEA newly developed high-throughput method for the quantitation of vitamin D using both multiplexed LC and on-line SPE is discussed.
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Mass Spectrometry in Analytical LipidomicsAn overview on the present state of analytical lipidomics is presented from the perspective of mass spectrometry (MS) and the MS strategies most frequently used in lipidomics are highlighted.
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Recent Advances in Pharmaceutical Analysis Using Transmission Raman SpectroscopyThis article reviews recent advances in the application of Transmission Raman Spectroscopy (TRS) to pharmaceutical analysis. The TRS technique overcomes subsampling limitations of conventional Raman spectroscopy and enables rapid non-invasive volumetric analysis of intact pharmaceutical tablets and capsules in a quantitative manner with relevance to quality and process control applications. Although only recently introduced to this area its uptake and the breadth of applications are rapidly growing with regulatory approvals for use of this technology in quality control of manufactured pharmaceutical products recently being granted.
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Detection of Chemicals with Standoff Raman SpectroscopyA compact standoff Raman system can be used to detect hazardous chemicals and chemicals used in homemade explosives synthesis.
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Comparison of Extracts from Dry and Alcohol-Steamed Root of Polygonatum kingianum (Huang Jing) by Sub-2-µm–LC–TOF-MSMost plants used in traditional Chinese medicine must be processed before their medicinal usage; hence the effective ingredients may differ from those in the freshly harvested plant extracts. In this work, we present a fast and generic approach using sub-2-?m liquid chromatography–time-of-flight–mass spectrometry (sub-2-?m-LC–TOF-MS) coupled with multivariate statistical data analysis to systematically profile ingredient changes between fresh and processed samples of huang jing.
