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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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High-Throughput Quantitative Analysis of Vitamin D Using a Multiple Parallel LC–MS System Combined with Integrated On-Line SPEA newly developed high-throughput method for the quantitation of vitamin D using both multiplexed LC and on-line SPE is discussed.
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Mass Spectrometry in Analytical LipidomicsAn overview on the present state of analytical lipidomics is presented from the perspective of mass spectrometry (MS) and the MS strategies most frequently used in lipidomics are highlighted.
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Recent Advances in Pharmaceutical Analysis Using Transmission Raman SpectroscopyThis article reviews recent advances in the application of Transmission Raman Spectroscopy (TRS) to pharmaceutical analysis. The TRS technique overcomes subsampling limitations of conventional Raman spectroscopy and enables rapid non-invasive volumetric analysis of intact pharmaceutical tablets and capsules in a quantitative manner with relevance to quality and process control applications. Although only recently introduced to this area its uptake and the breadth of applications are rapidly growing with regulatory approvals for use of this technology in quality control of manufactured pharmaceutical products recently being granted.
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Detection of Chemicals with Standoff Raman SpectroscopyA compact standoff Raman system can be used to detect hazardous chemicals and chemicals used in homemade explosives synthesis.
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Comparison of Extracts from Dry and Alcohol-Steamed Root of Polygonatum kingianum (Huang Jing) by Sub-2-µm–LC–TOF-MSMost plants used in traditional Chinese medicine must be processed before their medicinal usage; hence the effective ingredients may differ from those in the freshly harvested plant extracts. In this work, we present a fast and generic approach using sub-2-?m liquid chromatography–time-of-flight–mass spectrometry (sub-2-?m-LC–TOF-MS) coupled with multivariate statistical data analysis to systematically profile ingredient changes between fresh and processed samples of huang jing.
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A New Path to High-Resolution HPLC–TOF-MS — Survey, Targeted, and Trace Analysis Applications of TOF-MS in the Analysis of Complex Biochemical MatricesThe impact of speed of analysis and selectivity to the depth of coverage and accuracy of the analyses are discussed.
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A New Path to High-Resolution HPLC–TOF-MS — Survey, Targeted, and Trace Analysis Applications of TOF-MS in the Analysis of Complex Biochemical MatricesThe impact of speed of analysis and selectivity to the depth of coverage and accuracy of the analyses are discussed.
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How Much Pomegranate Is In Pomegranate Juice?Pomegranates are loaded with antioxidants and millions of people turn to pomegranate juice for its many health benefits, but every time you take a sip from a bottle of the popular juice, how much of the actual fruit are you consuming?
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Determination of the Relative Prevalence of Lurasidone Metabolites in Urine Using Untargeted HRMSFor lurasidone treatment adherence testing, an untargeted high-resolution mass spectrometry method was employed, using known positive human urine samples to identify the lurasidone metabolites and their relative abundance in urine.
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Advanced Structural Mass Spectrometry for Systems Biology: Pulling the Needles from HaystacksIon mobility–mass spectrometry (IM-MS) is outlined as a separations method, several examples of the utility of IM-MS for complex biological measurements are illustrated, and the implications of this approach for systems biology research are discussed.
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A Sensitive, Specific, Accurate, and Fast LC–MS-MS Method for Measurement of 42 Ethyl Glucuronide and Ethyl Sulfate in Human UrineA method is illustrated for the simultaneous analysis of ethyl glucuronide and ethyl sulfate in human urine samples.
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
Latest:
Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Probing Aqueous Surfaces by TOF-SIMSA breakthrough using a microfluidic interface to conduct sensitive time-of-flight secondary ion mass spectrometry (TOF-SIMS) analysis and study liquid surfaces in situ under vacuum conditions is described here.
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The pH Dependence of the SERS Spectra of Methyl Yellow in Silver ColloidSurface plasmon resonance, charge-transfer resonance, and their combination determine the enhancement of surface-enhanced Raman scattering signals, and the varying intensities of the signal at different pH levels may result from the change in contributions of the combined system.
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Determination of Sodium Lauryl Sulfate and Sodium Laureth Sulfate in Commercial Body Care ProductsA method for quantifying the percent sulfate associated with sodium lauryl sulfate (also referred to as sodium dodecyl sulfate) and sodium laureth sulfate (also referred to as sodium lauryl ether sulfate) found in commonly used commercial body care products using FT-IR attenuated total reflectance (ATR) spectroscopy is outlined.
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Quantifying Proteins by Mass SpectrometryThe quantification of proteins in a complex biological sample is an important and challenging task. Mass spectrometry (MS) is increasingly used for this purpose, not only to give a global survey of the components and their amounts, but also to precisely and accurately quantify specific target proteins.
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Quantitation of Albumin and Creatinine in Urine by MALDI-TOF Mass SpectrometryChronic kidney disease or kidney complication resulting from another systematic disorder can impact the organ’s blood filtering capability resulting in the passage of blood-born proteins through the kidneys and into urine. Clinical analyses for blood proteins in urine are performed to assess proper kidney function or to monitor a diagnosed disorder. Serum albumin is a common target in these clinical assays and detection of elevated SA levels in urine is termed Albuminuria. Because of normal variability in urine content and volume multiple measurements are often made in comparison to creatitine levels within the same urine sample and reported as a ratio (ACR). Demonstrated here is a novel means for quantifying albumin and creatinine directly from the same urine sample using MALDI-TOF mass spectrometry. Standard addition of albumin and deuterated creatinine (d3) into control urine produced a linear and quantitative response (R2 = 0.99 and 0.98) and is used to quantify both analytes across their clinically relevant ranges. This MS-based method represents a simple, fast, attractive alternative to currently clinical methods.
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Determination of Cannabinoid Content and Pesticide Residues in Cannabis Edibles and BeveragesQuEChERS is introduced to the discipline of forensic testing as a viable method for the extraction of pesticides and cannabinoids in various complex sample matrices.
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Lineshapes in IR and Raman Spectroscopy: A PrimerInfrared and Raman bands are typically described in terms of peak location and peak height. The shape of the peak-its form, width, and asymmetry-is less well understood. Bandshapes largely depend upon interactions between vibrating molecules and their environment. An understanding of this relationship may enhance spectral interpretation and can explain unexpected behaviors, in both qualitative and quantitative analyses. This paper presents basic concepts that influence line shapes and shows the complex lineshape changes in an apparently simple system of acetone and water.
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Atmospheric Applications IFS 125HRBruker's IFS 125HR spectrometer is designed as an ultra-high resolution FT-IR spectrometer which provides outstanding performance for R&D laboratory application.
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Chemical Analysis of Microscopic Fluorescent Materials by Dispersive 1064 Raman SystemRaman measurement on microscopic inclusions in fluorescent materials requires the ability to measure in small volumes, excellent throughput, and long wavelength excitation such as 1064 nm for fluorescence reduction.
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Gas Analysis with the Nicolet iS50 FT-IR SpectrometerCombining a high precision FT-IR spectrometer with a long pathlength gas cell provides a powerful tool for analyzing trace levels of contaminants in air and other gas mixtures (Figure 1). Two important applications of this are ensuring air quality and the purity of breathing oxygen and compressed air.
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Analyzing Absorption of Wood Preservatives Using Micro X-ray FluorescenceTo optimize the mapping collection parameters, it is important to factor the size of the mapping area, the beam diameter, and the desired beam spacing. For this sample, the area being mapped is shown in red outline in Figure 2, approximately 50.4 x 3.5 mm.
