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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Advances in Spectroscopy for Detection and Identification of Potential Bioterror AgentsMore-specific, sensitive, rapid, and portable spectroscopic methods detect biological threats.
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On-line Benchtop NMR Reaction MonitoringNMR spectra are chemically specific, enabling the measurements to be sensitive to molecular structure and reaction kinetics. Examples such as acetalisation of acetaldehyde are explained.
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ParticleFinder – Automated Particle Location and Raman Analysis with LabSpec 6Locate particles, generate size/shape statistics, select particles based on size/shape, and acquire Raman spectra. Easily locate and identify particulate matter, including pharmaceutical materials, trace forensic evidence, geological rock/mineral particles, and airborne contaminants trapped on filters
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Responding to Data Analysis and Evaluation Challenges in Mass Spectrometry–Based Methods for High-Throughput ProteomicsThis new data-management method is specifically designed to handle the large amounts of data produced in proteomics studies. Experimental methods and data are presented from a recent study conducting proteomics profiling of Schizosaccharomyces pombe to demonstrate the effectiveness of the data management solution. The results demonstrate enhanced data search speeds as well as effective data analysis.
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High-Resolution NIR AnalysisNew detector and optical bench options make it possible to configure near-infrared spectrometer setups for high-resolution applications such as laser and optical fiber characterization.
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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High-Definition Screening for Boar Taint in Fatback Samples Using GC–MSHigh-definition screening by gas chromatography–mass spectrometry (GC–MS) is shown to be a viable option for the reliable identification of odorous compounds in pork.
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Mass Spectrometry of Organic Molecules and Laser-Induced Acoustic Desorption: Applications, Mechanisms, and PerspectivesThis study illustrates the versatility of a laser-induced acoustic desorption (LIAD) approach for volatilization of analytes in modern mass spectrometry.
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The pH Dependence of the SERS Spectra of Methyl Yellow in Silver ColloidSurface plasmon resonance, charge-transfer resonance, and their combination determine the enhancement of surface-enhanced Raman scattering signals, and the varying intensities of the signal at different pH levels may result from the change in contributions of the combined system.
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Detection of Chemicals with Standoff Raman SpectroscopyA compact standoff Raman system can be used to detect hazardous chemicals and chemicals used in homemade explosives synthesis.
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Comparison of Extracts from Dry and Alcohol-Steamed Root of Polygonatum kingianum (Huang Jing) by Sub-2-µm–LC–TOF-MSMost plants used in traditional Chinese medicine must be processed before their medicinal usage; hence the effective ingredients may differ from those in the freshly harvested plant extracts. In this work, we present a fast and generic approach using sub-2-?m liquid chromatography–time-of-flight–mass spectrometry (sub-2-?m-LC–TOF-MS) coupled with multivariate statistical data analysis to systematically profile ingredient changes between fresh and processed samples of huang jing.
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Metabolomics Workflows: Combining Untargeted Discovery-Based and Targeted Confirmation Approaches for Mining Metabolomics DataThe metabolomics workflow described here combines untargeted (discovery) quadrupole time-of-flight (Q-TOF) liquid chromatography–mass spectrometry (LC–MS), targeted (confirmation) triple-quadrupole LC–MS-MS, and sophisticated data mining as an effective means to elucidate metabolite changes.
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Comprehensive Analysis of Persistent Organic Pollutants in Complex Matrices 48 Using GC with High-Performance TOF-MSThe combination of GC with time-of-flight (TOF)-MS proves to be a successful approach for the challenging analysis of persistent organic pollutants in complex matrices such as sediment and fish samples.
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Medical Imaging with Filters and Quantum DotsThe onset of nanotechnology and targeted therapy methods for a number of pathologies has made it increasingly more difficult to image effectively in the medical field. With that being said, the inception of quantum dots and the improvements to optical filters has made this once daunting task a common practice.
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High-Definition Screening for Boar Taint in Fatback Samples Using GC–MSHigh-definition screening by gas chromatography–mass spectrometry (GC–MS) is shown to be a viable option for the reliable identification of odorous compounds in pork.
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Why Use Signal-To-Noise As a Measure of MS Performance When It Is Often Meaningless?Signal-to-noise of a chromatographic peak from a single measurement has been used determine the performance of two different MS systems, but this parameter can no longer be universally applied and often fails to provide meaningful estimates of the instrument detection limits (IDL).
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Rapid and Accurate LC–MS-MS Analysis of Nicotine and Related Compounds in Urine Using Raptor Biphenyl LC Columns and MS-Friendly Mobile PhasesA rapid, accurate, and reproducible method was developed for high-throughput testing of nicotine, cotinine, trans-3’-hydroxycotinine, nornicotine, norcotinine, and anabasine in urine. Data show that a fast and highly efficient analysis of these basic compounds can be achieved with the Raptor Biphenyl column using standard reversed-phase LC–MS mobile phases that are compatible with a variety of LC–MS instrumentation.
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Discrimination of Lipids in Heart Tissue using DESI HRMS MSIMass Spectrometric Imaging (MSI) using DESI provides molecular imaging without the interference of the matrix required for MALDI and offers the advantage of preserving sample for further analysis. DESI coupled to High Resolution Accurate Mass (HRAM), is shown here to elucidate spatial distribution of lipids, protein, and metabolites in tissue sections and can provide confident and discriminate biomarker determinations.
Latest:
Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Metabolomics Workflows: Combining Untargeted Discovery-Based and Targeted Confirmation Approaches for Mining Metabolomics DataThe metabolomics workflow described here combines untargeted (discovery) quadrupole time-of-flight (Q-TOF) liquid chromatography–mass spectrometry (LC–MS), targeted (confirmation) triple-quadrupole LC–MS-MS, and sophisticated data mining as an effective means to elucidate metabolite changes.
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How to Design a Miniature Raman SpectrometerIn this article, we describe the key factors that influence the overall size of a spectrometer, such as the diffraction grating groove density and detector size. Furthermore, we demonstrate compact Raman spectrometer designs as small as 30 mm × 30 mm in footprint by using highly dispersive gratings and uncooled detectors.
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Advancements in Low Cost Miniature NIR Spectrometers Enable New Applications in Sample Identification and Quality ControlNear-infrared spectroscopy (NIR) is a powerful technique for rapid and non-destructive material analysis. Scientific breakthroughs over the past several decades have made NIR one of the most powerful tools for research, especially in industries such as food and drug, chemical, oil and gas, and plastics. This technique has mainly been limited to non-portable applications due to instrument size, fragility, and cost. Additionally, Database Search Software or Multivariate Prediction Software must also be employed to extract results; however, user-friendly and cost effective solutions have not been widely available.
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Imaging Mass Spectrometry: Current Performance and Upcoming ChallengesA critical look into the future of imaging mass spectrometry is made by addressing some of the fundamental and technical challenges that still need to be overcome.
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25-Hydroxyvitamin D2/D3 Analysis in Human Plasma Using LC–MSIncreases in vitamin D testing frequency have required more rapid and cost-effective solutions for determining vitamin D levels in plasma. This LC–MS method was adapted for use with core-shell columns to achieve run times of less than 4 min.
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Creating a High-Throughput LC–MS-MS System Using Common ComponentsHow to create a liquid chromatography–tandem mass spectrometry (LC–MS-MS) system using mass spectrometers, a high performance liquid chromatography (HPLC) binary pump system, and an autosampler
