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An Accurate-Mass Database for Screening Pesticide Residues in Fruits and Vegetables by Gas Chromatography–Time-of-Flight Mass SpectrometryThe main objective of this study was to evaluate the capabilities of gas chromatography (GC) with time-of-flight mass spectrometry (MS) for screening pesticides in fruits and vegetables using a purpose-built accurate-mass database.
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An Accurate-Mass Database for Screening Pesticide Residues in Fruits and Vegetables by Gas Chromatography–Time-of-Flight Mass SpectrometryThe main objective of this study was to evaluate the capabilities of gas chromatography (GC) with time-of-flight mass spectrometry (MS) for screening pesticides in fruits and vegetables using a purpose-built accurate-mass database.
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An Accurate-Mass Database for Screening Pesticide Residues in Fruits and Vegetables by Gas Chromatography–Time-of-Flight Mass SpectrometryThe main objective of this study was to evaluate the capabilities of gas chromatography (GC) with time-of-flight mass spectrometry (MS) for screening pesticides in fruits and vegetables using a purpose-built accurate-mass database.
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Ion Manipulation by Digital Waveform TechnologyDigital waveform technology is emerging as a powerful tool in mass spectrometry (MS). Digital quadrupoles rely on precise control of frequency rather than voltage, which allows these devices to access a greatly extended mass range
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Ion Manipulation by Digital Waveform TechnologyDigital waveform technology is emerging as a powerful tool in mass spectrometry (MS). Digital quadrupoles rely on precise control of frequency rather than voltage, which allows these devices to access a greatly extended mass range
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Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical AnalysesA newly discovered method is described for generating gas-phase ions from volatile and nonvolatile compounds. The method, matrix-assisted ionization (MAI), is both simple and sensitive, requiring only the vacuum inherent with all mass spectrometers and a suitable matrix, eliminating the need for lasers, electric fields, nebulizing gas, and even heaters to generate gas-phase ions. MAI is applicable for the direct analysis of drugs from biological fluids and tissue without prior purification. By placing matrix only on a specific surface area of interest and exposure to the vacuum of the mass spectrometer, ions are observed from compounds within the targeted surface area of tissue exposed to the matrix solution, thus allowing rapid and simple interrogation of “features of interest.” The limit of detection for drug standards is low attomoles and clean full mass range mass spectra are obtained from low femtomoles of the drug.
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Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
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Solvent Assisted Ionization Mass Spectrometry for Screening and Quantification of Counterfeit DrugsBecause of the wide variety of ways counter drugs have been entering the pharmaceutical supply chain, there is an imminent need for quick and inexpensive methods to identify drug components and quantify active ingredients. Here, we report results illustrating the screening properties of solvent assisted ionization mass spectrometry (SAI-MS) and the quantitative properties of liquid chromatography (LC)-SAI-MS. These methods offer high sensitivity, versatility, and in combination, rapid turnaround time. Suspect samples of fexofenadine hydrochloride and hydroxychloroquine were rapidly screened and compared to their legal counterparts using SAI-MS.
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Characterization of SiO2 on Glass by Spectroscopic EllipsometryMeasuring thickness and optical constants of transparent films on transparent substrates can be a challenge for spectroscopic ellipsometry. The sensitivity of the HORIBA UVISEL ellipsometer allows this challenging task to be easily performed.
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Sunscreen Testing According to COLIPA 2011/FDA Final Rule 2011 Using UV/Vis LAMBDA SpectrophotometersSun Protection Factor (SPF) allows consumers to compare protection provided by sunscreens. Standardized methods properly evaluate the level of protection from UVA / UVB, and confirm label claims of their effectiveness.
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Detection of Honey Adulteration Using FT-NIR SpectroscopyFraudulent mislabeling of honey is an increasing concern, due to its high-value. NIR Spectroscopy detects known and unknown adulterants in honey, quickly and easily.
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Mass Spectrometry in Analytical LipidomicsAn overview on the present state of analytical lipidomics is presented from the perspective of mass spectrometry (MS) and the MS strategies most frequently used in lipidomics are highlighted.
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In-Field Measurements of Major Elements and Base Metals with Handheld LIBSThe Z-500 also analyzes base metals and trade elements, including Mg, Ti, V, Cr, Fe, Mn, Cu, Ni, and others. Trace metals of commercial interest or as pathfinders including Li, Be, B, C, and halogens including F, Cl, and Br are also analyzed. Figure 2 shows results for Li analysis, as an example. The results for lithium analysis were reasonably good. While there is some scatter in the data, the HH LIBS is measuring very low concentrations, in the 10–30 ppm concentration range. In general, the results for B, Be, Mg, Ba, and other elements were comparable, in terms of correlation, with the Li data.
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stainless and low alloy steel analysis using handheld LIBSAnalysis of stainless steels and nickel alloys with handheld LIBS has proven challenging because Molybdenum – a key alloy element in the 0.5-3% level – is refractory and requires a much hotter plasma than many miniature, commercially available lasers can provide. A new proprietary laser design was utilized in a handheld LIBS analyzer and is shown to provide much better quantitative analysis of Mo down to 0.15% concentration.
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Counterfeit Olive Oil DetectionOlive oil production is a multibillion industry, with food-grade varieties subject to regulation regarding their origin and quality. In this application note, the Ocean Optics Spark spectral sensor identifies potentially damaging adulterants and dilutions in olive oil samples.
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The 2017 Emerging Leader in Atomic Spectroscopy AwardThe winner of Spectroscopy's inaugural Emerging Leader in Atomic Spectroscopy Award is highlighted.
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From the PublisherFor 30 years, Spectroscopy has provided its readers with valuable content, advice, troubleshooting tips, and insight to many areas of materials analysis. Our mission statement says
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Molecular Characterization of Gadolinium-Doped Zinc Telluride Films by X-ray Photoelectron SpectroscopyZinc telluride films doped with gadolinium (ZnTe:Gd)-made by laser ablation and deposition-have been characterized by X-ray photoelectron spectroscopy (XPS) to determine the molecular species of the elements in the material and their presence as intentionally formed contaminants.
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Molecular Characterization of Gadolinium-Doped Zinc Telluride Films by X-ray Photoelectron SpectroscopyZinc telluride films doped with gadolinium (ZnTe:Gd)-made by laser ablation and deposition-have been characterized by X-ray photoelectron spectroscopy (XPS) to determine the molecular species of the elements in the material and their presence as intentionally formed contaminants.
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Molecular Characterization of Gadolinium-Doped Zinc Telluride Films by X-ray Photoelectron SpectroscopyZinc telluride films doped with gadolinium (ZnTe:Gd)-made by laser ablation and deposition-have been characterized by X-ray photoelectron spectroscopy (XPS) to determine the molecular species of the elements in the material and their presence as intentionally formed contaminants.
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Analysis of Composite Films using FTIRComposite films are mainly used for the packaging of food where many requirements have to be met in order to preserve taste and freshness of the product. Packaging needs to prevent water vapor from entering or leaving the packaging. FTIR Microscopy allows for the identification of different materials in composite films and can determine their distributions. Furthermore, defects in polymer matrix can also be localized and identified.
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Techniques for Raman Analysis of Lithium-Ion BatteriesThe needs of the lithium-ion battery customers can be segmented into in situ and ex situ modes of analysis. In situ analysis allows researchers to follow changes in a battery cell during its charge and discharge cycles.
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Techniques for Raman Analysis of Lithium-Ion BatteriesThe needs of the lithium-ion battery customers can be segmented into in situ and ex situ modes of analysis. In situ analysis allows researchers to follow changes in a battery cell during its charge and discharge cycles.
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Raman Spectroscopy of Pharmaceutical Ingredients Under Humidity Controlled AtmosphereExposure to warm/humid conditions may cause pharmaceutical formulations to undergo change in hydration level, affecting properties and/or efficiency of the drug. Raman spectroscopy, with a temperature and humidity controller can mimic harsh conditions, monitor properties of ingredients and track modifications induced by environmental changes.
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Characterization of Encapsulated Flavours using Raman SpectroscopyRaman spectroscopy has been used to analyze the process of micro-encapsulation of flavors. This contribution shows the example of distribution of limonene and quantification of its content within the micro-particles.
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How to Design a Miniature Raman SpectrometerIn this article, we describe the key factors that influence the overall size of a spectrometer, such as the diffraction grating groove density and detector size. Furthermore, we demonstrate compact Raman spectrometer designs as small as 30 mm × 30 mm in footprint by using highly dispersive gratings and uncooled detectors.
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How to Design a Miniature Raman SpectrometerIn this article, we describe the key factors that influence the overall size of a spectrometer, such as the diffraction grating groove density and detector size. Furthermore, we demonstrate compact Raman spectrometer designs as small as 30 mm × 30 mm in footprint by using highly dispersive gratings and uncooled detectors.
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How to Design a Miniature Raman SpectrometerIn this article, we describe the key factors that influence the overall size of a spectrometer, such as the diffraction grating groove density and detector size. Furthermore, we demonstrate compact Raman spectrometer designs as small as 30 mm × 30 mm in footprint by using highly dispersive gratings and uncooled detectors.
