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Latest:
Unilateral Nuclear Magnetic Resonance for Quality Control: The NMR-MOUSE (pdf)This article discusses the principles of unilateral nuclear magnetic resonance with applications to elastomers and nondestructive in situ inspection of a wet fresco from ancient Rome.
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In-Line Process Analysis of Residual Moisture in a Fluid Bed Granulator-Dryer Using NIR Spectroscopy (PDF)The authors describe the in-line moisture measurement of a pharmaceutical granulation of lactose, microcrystalline cellulose, and crospovidone in a fluid bed granulator-dryer using top sprayed granulating liquid. A near-infrared (NIR) prediction model was developed for moisture on spectra collected during a calibration run. Subsequent granulations were analyzed for moisture content real-time throughout the granulation and drying process using the NIR process instrument.
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IMS for Cleaning Verification (PDF)The need to verify cleaning between manufacturing runs presents a special challenge to the analytical chemist. In this article, the principles of ion mobility spectrometry are described, its performance is compared to HPLC for the analysis of cleaning validation samples, and findings are presented from a study to establish the feasibility of using IMS in validating a cleaning verification method.
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Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
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Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
Latest:
Unilateral Nuclear Magnetic Resonance for Quality Control: The NMR-MOUSE (pdf)This article discusses the principles of unilateral nuclear magnetic resonance with applications to elastomers and nondestructive in situ inspection of a wet fresco from ancient Rome.
Latest:
Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
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Sampling Accessories for the High-Throughput Analysis of Combinatorial Libraries Using Spectral Imaging (PDF)This article describes several sampling accessories, designed by the authors, that allow a variety of combinatorial systems to be analyzed.
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Analysis of Fusarium Toxins Using LC?MS-MS (PDF)The authors present an MS technique that reliably detects several types of fungal mycotoxins, and compare electrospray ionization and atmospheric chemical ionization techniques.
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Test of an In Vivo Method to Detect Chloroplast Division in Crop Plants, Part III: Statistical Proofs of Observation and General Utility of the Method (PDF)This article is the third installment in a series about a novel spectrofluorometric method that allow for in vivo observation of the division of chlorplast populations in leaves of Arabidopsis thalania.
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Tech Note: High-Resolution Ultrasonic Spectroscopy for Analysis of Chemical Reactions in Real Time (PDF)This article discusses direct real-time monitoring of chemical reactions, an important tool in industrial processes in industries such as chemical, biotechnology, food, and pharmaceutical.
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FT-IR Microscopic Analysis of Polymer Laminate Samples Including Transmission and ATR SpectroscopyPolymer laminates typically make complex samples for infrared analysis, comprising multiple layers with defined thicknesses, in some cases less than 10 µm. When measuring extremely narrow laminate layers, the use of attenuated total reflectance (ATR) may provide improved spectra of the laminate cross-section, because ATR microscope objectives offer a greater spatial resolution than transmission due to additional magnification. This paper details the preparation of polymer laminate sample cross-sections and the collection of transmission and ATR spectra of various layers. Further analysis of the laminate spectra will also be explored utilizing a multivariate curve resolution (MCR) algorithm. An example laminate sample is examined utilizing all the tools available on a standard FT-IR microscope.
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Can We Simplify Data Process Mapping?Data process mapping is an effective way to identify data integrity vulnerabilities and remediate them. A modified example published by the Active Pharmaceutical Ingredients Committee (APIC) is reviewed critically. Can it be simplified?
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Detection of g-Hydroxybutyrate and g-Butyrolactone by Ion Mobility Spectrometry (PDF)The authors discuss g-hydroxybutyrate (GHB), a drug of abuse that is not detected in the drug-detection mode or positive polarity of commercial ion mobility spectrometers, but can be detected by ion mobility spectrometry (IMS) instruments in negative mode.
Latest:
Unilateral Nuclear Magnetic Resonance for Quality Control: The NMR-MOUSE (pdf)This article discusses the principles of unilateral nuclear magnetic resonance with applications to elastomers and nondestructive in situ inspection of a wet fresco from ancient Rome.
Latest:
PAT, NeSSI, and Sample Conditioning Systems: State of the Technologies and Future Directions (PDF)This article reviews the development of FDA's PAT Initiative along with CPAC's ANSI/ISA-76.00.02 (2002) (NeSSI) development. The intent is to show how the NeSSI components could contribute to the PAT philosophy and physical requirements.
Latest:
Unilateral Nuclear Magnetic Resonance for Quality Control: The NMR-MOUSE (pdf)This article discusses the principles of unilateral nuclear magnetic resonance with applications to elastomers and nondestructive in situ inspection of a wet fresco from ancient Rome.
Latest:
Analysis of Fusarium Toxins Using LC?MS-MS (PDF)The authors present an MS technique that reliably detects several types of fungal mycotoxins, and compare electrospray ionization and atmospheric chemical ionization techniques.
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Powerful Partners Provide Complete Analytical Solutions (PDF)This article examines advances that have been made to combine existing analytical techniques with Raman instrumentation. Some of these methods offer enhanced sample visualization, while others provide complementary vibrational spectroscopic information from a single sample point.
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Raman Spectroscopy for Homeland Defense Applications (PDF)Raman spectroscopy is used routinely by the agencies tasked with homeland defense, and current research using surface enhanced Raman spectroscopy shows promise for the detection of chemical warfare agents and other toxic chemicals. This article overviews some of the latest developments in the field.
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Post-Tableting NIR Analysis: A Look at PAT Applicability to the Output of Solid Dosage Forms (PDF)A majority of current discussion about NIR's applicability to pharmaceutical manufacturing is focused on preparative processes such as granulation, drying, and blending. The author examines different considerations for NIR for the output of the manufacturing line - finished tablet analysis.
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Using Dynamic Reaction Cell ICP-MS to Determine the Full Suite of Elements in Rainwater Samples (PDF)This paper describes how analysts at an environmental and geochemical laboratory utilize dynamic reaction cell ICP-MS technology to study the transport and deposition of important trace metals from rainwater.
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Characterizing Microplastic Fibers Using Raman SpectroscopyIn this study, macro- and microscopic Raman spectroscopy were used to identify different commercial microplastic fibers using measured spectra with database searches. Raman microscopy is demonstrated as a powerful technique for microplastic fiber characterization, especially for samples that contain mixtures of components, including multiple polymers, or additives.
Latest:
Test of an In Vivo Method to Detect Chloroplast Division in Crop Plants, Part III: Statistical Proofs of Observation and General Utility of the Method (PDF)This article is the third installment in a series about a novel spectrofluorometric method that allow for in vivo observation of the division of chlorplast populations in leaves of Arabidopsis thalania.
Latest:
ICP-MS: When Sensitivity Does MatterIt makes intuitive sense - the higher the sensitivity of an inductively coupled plasma–mass spectrometry (ICP-MS) system, the lower the detection limit. But there are many factors that affect the detection limit for a given isotope in a given sample. These factors include sensitivity, background noise, and interferences.
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Identifying Macromolecules (PDF)The authors review a surface enhanced laser Raman spectroscopy study of lung surfactant protein interaction with bacterial lipopolysaccharide.
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Identification of Unanticipated Compounds by High-Resolution Mass Spectrometry (PDF)Often, mass spectra of compounds found in water supplies are not found in mass spectral libraries. Ion composition elucidation (ICE) provides the elemental compositions of the ions observed in their mass spectra. This information is used to identify the compounds.
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Molecular Spectroscopy Workbench Near-infrared Chemical Imaging and the PAT Initiative (PDF)NIR-CI adds a completely new dimension to conventional spectroscopy.
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Tech Note: Diffractive MEMS in SpectroscopyMEMS are small, microfabricated devices that are finding application in a variety of industries in both analytical and manufacturing settings. This paper reviews the properties of diffractive MEMS devices and examines their application in chemical spectroscopy.
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Tutorial — Mass Analyzers: An Overview of Several Designs and Their Applications, Part IIThe second installment of this two-part series illustrates further technical principles and applications of the most common mass analyzers used in bioanalytical laboratories today, as well as novel techniques and mass analyzer designs. Examples are based upon the authors' research in small molecule applications.
