Biological, Medical, and Clinical Analysis

In this interview, James Chapman discusses his current and future research efforts, and how combining spectroscopy with machine learning tools can change how bacterial research is conducted.

Mathew Horrocks, the 2023 recipient of The Joseph Black Prize, shares his thoughts about his current work developing and using single-molecule and super-resolution microscopy techniques to study amyloid oligomers and their commonality regarding a variety of neurodegenerative disorders.

In this interview, Jürgen Popp discusses the importance of Raman spectroscopy, where it can make a difference, and how it can be evolved and improved on in the future.

A team of researchers has conducted a successful round-robin test using total reflection X-ray fluorescence (TXRF) to analyze the elemental composition of rat tissue samples. The preliminary results demonstrate the effectiveness of TXRF in accurately determining the elemental composition of mammalian tissue.

Researchers have developed a near-infrared fluorescent probe that allows for highly sensitive detection of butyrylcholinesterase activity and pesticide residue in food samples. The probe offers a ratiometric pattern and shows promise for applications in health evaluation, disease diagnosis, and environmental monitoring.

A research team has utilized the Allan variance technique to analyze the performance characteristics of compact Fourier transform infrared (FT-IR) spectrometers. The study provides insights into the noise sources and instabilities of these handheld instruments, offering guidance for improving their accuracy and stability in real-time material detection and quantification applications.

Scientists have conducted a spectroscopic analysis of 2-amino-1-naphthalenesulfonic acid, exploring its electronic properties and its potential as an antiviral agent.

Biomedical Raman imaging is growing in the biomedical space, where technical advances and new information processing tools and techniques aim to propel the field into the future. An upcoming conference in Atlanta, Georgia, will explore these developments while bringing scientists in this field together.

A recent study explored the binding characteristics of the tyrosine kinase inhibitor entrectinib with bovine serum albumin through multi-spectral analysis and theoretical calculations, revealing the factors affecting the stability of the ENB-BSA complex and potential ways to enhance the efficacy of ENB.

This interview with Young Jong Lee highlights the work he and his team have done to reinvent solvent absorption compensation (SAC), and the potential it has across multiple forms of spectroscopy.

Terahertz time-domain spectroscopy was used to identify and analyze the low-frequency vibrational modes of three free anthraquinones, revealing the vibrational contributions of different atoms and groups.

SERS of centrifuged blood serum samples of diabetic type II patients using 50 KDa filter devices can diagnose the disease at an early stage by studying small molecular weight proteins.

Researchers have developed a method for the simultaneous determination of cadmium and lead in water samples using microwave-induced plasma optical emission spectrometry with multiwalled carbon nanotubes pre-concentration and a discrete sample introduction system.

Gary McGeorge, Scientific Director at Bristol-Myers Squibb, spoke to us of the benefits and challenges associated with establishment of consistent resolutions while facilitating the steps associated with the implementation of process analytical technology (PAT).

The United States Pharmacopeia–National Formulary (USP–NF) has contributed to ensuring the quality of dietary supplements, foods, and medicines for more than 200 years. This overview explains the use of vibrational spectroscopy techniques in meeting USP–NF requirements and how the information is organized.

A multiscale convolutional neural network (MsCNN) was used to screen Raman spectra of the hepatitis B serum, achieving higher classification accuracy compared to traditional machine learning methods.

Zac Schultz of The Ohio State University and his team used tip-enhanced Raman spectroscopy (TERS) and surface-enhanced Raman spectroscopy (SERS) with gold nanostars to investigate chemical reactions involved in protein–ligand binding. He recently spoke with Spectroscopy about his findings.

Bhavya Sharma is the winner of the 2021 Emerging Leader in Molecular Spectroscopy Award. We recently interviewed her about her work conducting research to detect active and important biomolecules related to hormone regulation, neurological health, and disease diagnosis.

Mark Meyerhoff has been exploring chemical sensors for biomedical applications. Because of his work, Meyerhoff has been awarded the 2021 ANACHEM award. Meyerhoff spoke to us about his work, his career, and what being presented this award at this fall’s SciX event means to him.

Professor Rohit Bhargava and his team at the University of Illinois, where they have established the Cancer Center at Illinois, are advancing research in tumor microenvironments, using techniques such as high-definition Fourier transform infrared (HD-FT-IR) coupled with machine learning. We recently spoke to Bhargava about this work.

Uwe Karst of the University of Münster in Germany explains the use of laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) imaging to provide spatially resolved quantification of trace elements in biological samples.

This year’s molecular spectroscopy award recipient is Bhavya Sharma, who is demonstrating research leadership focused on neurochemical detection using SERS and SORS Raman spectroscopy.

Uwe Karst of the University of Münster in Germany explains the use of laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) imaging to provide spatially resolved quantification of trace elements in biological samples.

In precious samples, effective methods for multielemental analysis could provide a deeper understanding of the essential role of elements as cofactors in biological and pathological processes. Tobias Konz of Nestlé Research explains.

Medical diagnostics is an exciting area of spectroscopy research, and one of the dreams is to develop spectroscopic tools that can be used for point-of-care diagnostics with a smartphone. Russ Algar, the 2017 Emerging Leader in Molecular Spectroscopy, is one of the scientists on that quest

Fourier Transform Infrared (FTIR) imaging is a well-established analytical method for obtaining spectral and spatial information simultaneously in the micron-size domain. The technique has been applied across many different application areas, from polymer science to biomedical imaging. Over recent years, interest has increased in pushing the diffraction limited spatial resolution performance of FTIR imaging systems, primarily using synchrotron based systems.

Mammals require dietary-based polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid (AA) for many biological processes, including normal functioning of the retina and brain. Fourier transform infrared (FTIR) imaging with high spatial resolution is a suitable tool to investigate the PUFA distribution in tissue sections from animal models of disease, providing comprehensive information of the biochemical components on the subcellular scale.

Fourier transform infrared (FTIR) microscopic imaging uses a combination of an FTIR spectrometer with a microscope and Focal Plane Array (FPA) detector. The method has been recognized as a powerful and versatile imaging tool in many disciplines, ranging from biomedical research through to materials science, art conservation and forensics.

The Coblentz Society and the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) recently named Professor Duncan Graham of the University of Strathclyde (Glasgow, Scotland) as the recipient of the Coblentz Society?s 2012 Craver Award.

The authors discuss the combined use of Raman and FT-IR spectroscopy in fields such as forensic science, biomedical science, catalysis, and polymers.