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A Simple and Effective ICP-MS Method Capable of Detecting Trace and Major Elements in Milk SamplesThe method described here is a simple method for detection of a wide spectrum of metals and for quantitative analysis over a wide dynamic range of elements, including both toxic metals and those metals essential for health and well-being.
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Simple Method for Monitoring Protein Secondary Structure During Thermal Unfolding and AggregationProtein secondary structure during thermal unfolding and aggregation is readily acquired using IR spectroscopy and a temperature-controlled mid-IR transmission accessory. Myoglobin was used as a model system to illustrate the method.
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Optimization of the Electrospray Ionization Source with the Use of the Design of Experiments Approach for the LC–MS-MS Determination of Selected Metabolites in Human UrineSimultaneous quantification of metabolites in biological fluids, where they are present at different concentration levels, is usually a challenging analytical task. One of the steps that should be undertaken to increase analytical method efficiency is optimization of the electrospray ionization source (ESI), which can be especially helpful in increasing method sensitivity of agents with poor ionization characteristics. We present here a step-by-step ESI optimization strategy with the use of the design of experiments (DoE. This multivariate statistical approach allows effective evaluation of the effects of multiple factors and interactions among factors on a given response in a minimum number of experimental runs.
Latest:
Optimization of the Electrospray Ionization Source with the Use of the Design of Experiments Approach for the LC–MS-MS Determination of Selected Metabolites in Human UrineSimultaneous quantification of metabolites in biological fluids, where they are present at different concentration levels, is usually a challenging analytical task. One of the steps that should be undertaken to increase analytical method efficiency is optimization of the electrospray ionization source (ESI), which can be especially helpful in increasing method sensitivity of agents with poor ionization characteristics. We present here a step-by-step ESI optimization strategy with the use of the design of experiments (DoE. This multivariate statistical approach allows effective evaluation of the effects of multiple factors and interactions among factors on a given response in a minimum number of experimental runs.
Latest:
Optimization of the Electrospray Ionization Source with the Use of the Design of Experiments Approach for the LC–MS-MS Determination of Selected Metabolites in Human UrineSimultaneous quantification of metabolites in biological fluids, where they are present at different concentration levels, is usually a challenging analytical task. One of the steps that should be undertaken to increase analytical method efficiency is optimization of the electrospray ionization source (ESI), which can be especially helpful in increasing method sensitivity of agents with poor ionization characteristics. We present here a step-by-step ESI optimization strategy with the use of the design of experiments (DoE. This multivariate statistical approach allows effective evaluation of the effects of multiple factors and interactions among factors on a given response in a minimum number of experimental runs.
Latest:
Optimization of the Electrospray Ionization Source with the Use of the Design of Experiments Approach for the LC–MS-MS Determination of Selected Metabolites in Human UrineSimultaneous quantification of metabolites in biological fluids, where they are present at different concentration levels, is usually a challenging analytical task. One of the steps that should be undertaken to increase analytical method efficiency is optimization of the electrospray ionization source (ESI), which can be especially helpful in increasing method sensitivity of agents with poor ionization characteristics. We present here a step-by-step ESI optimization strategy with the use of the design of experiments (DoE. This multivariate statistical approach allows effective evaluation of the effects of multiple factors and interactions among factors on a given response in a minimum number of experimental runs.
Latest:
Optimization of the Electrospray Ionization Source with the Use of the Design of Experiments Approach for the LC–MS-MS Determination of Selected Metabolites in Human UrineSimultaneous quantification of metabolites in biological fluids, where they are present at different concentration levels, is usually a challenging analytical task. One of the steps that should be undertaken to increase analytical method efficiency is optimization of the electrospray ionization source (ESI), which can be especially helpful in increasing method sensitivity of agents with poor ionization characteristics. We present here a step-by-step ESI optimization strategy with the use of the design of experiments (DoE. This multivariate statistical approach allows effective evaluation of the effects of multiple factors and interactions among factors on a given response in a minimum number of experimental runs.
Latest:
Liquid Chromatography Tandem Mass Spectrometry Method for Novel Psychoactive Substances: Kratom and Synthetic Cathinones in UrineA novel “dilute-and-shoot” LC–MS/MS method is described for the analysis of “bath salts” sold as “legal” highs, including mitragynine and nine synthetic cathinones, in urine.
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Light and Medium Petroleum Distillate Characterization Using Two-Dimensional Gas Chromatography–High-Resolution Time-of-Flight Mass Spectrometry and Enhanced Software ProcessingThe enhanced resolution of comprehensive two-dimensional gas chromatography (GCxGC) was combined with the increased resolving power, speed, and mass accuracy of the Pegasus® HRT's mass analyzer to confidently characterize molecules in light cycle oil (LCO) and vacuum gas oil (VGO). Optimized chromatographic and mass spectrometry parameters were implemented to improve data acquisition, processing, and heteroatomic speciation of these light to midlevel petroleum fractions. Software tools were utilized to process the data and facilitate robust compound identifications. GCxGC-HRT data was processed using comprehensive Peak Find and resulted in comprehensive characterization of molecules in LCO and VGO samples. Compound classes consisted of, but were not limited to alkanes, cycloalkanes, aromatics, benzothiophenes, and carbazoles. Selective processing of alkylbenzothiophenes and dibenzothiophenes was conducted by retrospectively processing data using rapid two-dimensional, accurate mass Target Analyte Finding (TAF).
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Interleaved Time-Resolved FT-IR SpectroscopyTime-resolved FTIR spectroscopy (TRS) is widely used to characterize the kinetics of single shot chemical reactions via rapid-scan or repeatable kinetics via the step-scan technique. For a certain class of repeatable experiments, interleaved FT-IR spectroscopy can be a powerful and easy-to-use alternative with clear advantages regarding signal-to-noise ratio and/or measurement duration. No other FT-IR manufacturer offers this capability.Hi
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Enhanced Raman Reflection Spectroscopy for Process Analytical TechnologyA novel approach in Raman spectroscopy enables bulk material analysis without the need for specialized equipment. Enhanced Raman reflection can be integrated into current processes using available instrumentation, enabling real-time process measurement and control.
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Raman Spectroscopy in Analyzing Fats and Oils in FoodsSeveral types of Raman spectroscopy, including Fourier transform (FT)–Raman and dispersive Raman, are well suited to examine and understand the fat compositional heterogeneity in solid foods, identify polymorph or crystallinity, and measure fatty acid saturation.
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A Sampling Flexibility for Raman SpectroscopyKey Issues: Sampling flexibility of Raman enables in-process analysis of solids, turbid media, liquids, and gases Large volumetric Raman provide representative sampling of heterogenous solids
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Use of the Agilent Multimode Sample Introduction System (MSIS) for Simultaneous Hydride Determination and Conventional Nebulization Using the PerkinElmer Optima 7/8x00 Series ICP-OESThe Agilent Multimode Sample Introduction System (MSIS) is an innovative option for both PerkinElmer Optima ICP-OES instruments and Agilent ICP-OES and Agilent MP-AES instruments. In this application note, we will show you how MSIS could help saves set-up and analysis time and also keep the lab as productive as possible.
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Testing Motor and Hydraulic Oils with the PearlTest new and used motor and hydraulic oils with the new liquid transmission analysis essential from Specac, the PearlTM.
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Multi-Toxin Determination in Food: The Power of “Dilute and Shoot” Approaches in LC–MS–MSThis article provides useful tips for smooth validation of multi-analyte LC–MS-MS methods and summarizes important validation outcomes for 295 analytes, including more than 200 mycotoxins.
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Multi-Toxin Determination in Food: The Power of “Dilute and Shoot” Approaches in LC–MS–MSThis article provides useful tips for smooth validation of multi-analyte LC–MS-MS methods and summarizes important validation outcomes for 295 analytes, including more than 200 mycotoxins.
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Real-Time, Broad-Spectrum Odor Analysis Using SIFT-MSThe sensitive, selective, and real-time analysis characteristic of the SIFT-MS technique provides simple, robust, and continuous analysis of extremely diverse odor compounds at trace levels in air. This application note illustrates instantaneous, broad spectrum odor analysis with monitoring data from a chicken meat production facility.
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Photoluminescence and Electroluminescence of Organic OptoelectronicsPhotoluminescence and electroluminescence spectroscopy is a useful technique in the investigation of organic optoelectronic devices. The instrumentation for steady-state and time-resolved photoluminescence, as well as electroluminescence, is specified in this application note on organic solar cells.
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Soil Sample Preparation for Pesticide AnalysisPreparing soil samples for pesticide analysis is a crucial step in ensuring the safety of all consumers. Typical soil samples for analysis are often a heterogeneous mix that are unable to be directly analyzed; thus, the handling and homogenizing of the sample must conducted with the proper tools and techniques in order to obtain a reproducible and meaningful result.
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Up-conversion Spectroscopy Made SimpleUp-conversion finds important applications from biological labels to sensors and solar cells. This application note elucidates the experimental requirements for the characterisation of up-conversion using lanthanides as a model material.
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Photoluminescence and Electroluminescence of Organic OptoelectronicsPhotoluminescence and electroluminescence spectroscopy is a useful technique in the investigation of organic optoelectronic devices. The instrumentation for steady-state and time-resolved photoluminescence, as well as electroluminescence, is specified in this application note on organic solar cells.
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In Situ Enhancement of Microplastic Raman Signals in Water Using Ultrasonic CaptureOf the 78 million tons of plastic packaging manufactured every year, approximately one-third ends up in the ocean, the air, and most foods and beverages. To monitor the proliferation of these plastics, an ultrasonic capture method is demonstrated that produces a 1500-fold enhancement of Raman signals of microplastics in water.
