Product Resources
The AccuTOF-DART mass spectrometer from JEOL is designed for direct analysis of surfaces, liquids, and gases without sample preparation. Applications include forensics investigations, pharmaceutical testing and development, environmental and homeland security response, and product analysis. JEOL USA, Peabody, MA; www.jeol.com
Mass spectrometer
The AccuTOF-DART mass spectrometer from JEOL is designed for direct analysis of surfaces, liquids, and gases without sample preparation. Applications include forensics investigations, pharmaceutical testing and development, environmental and homeland security response, and product analysis. JEOL USA, Peabody, MA; www.jeol.com
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Micro HPLC systems
Dionex's UltiMate 3000 micro HPLC systems for LC and LC–MS applications feature a range of modules, including five micro pump systems that offer flow rates of 10 µL/min to several mL/min. The systems are designed for separations on 1–3 mm i.d. columns. They can achieve cycle times of less than 1 min, gradient delay volumes of 60 µL, and injection cycles of less than 15 s. Dionex Corp., Sunnyvale, CA; www.dionex.com
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Molecular imager
Bruker Daltonics' MALDI Molecular Imager is designed for in-vitro imaging of peptide and protein biomarker distributions in tissue sections and cell clusters, for example from tumor regions. The system features the company's MALDI-TOF mass spectrometer for high-throughput MALDI imaging together with the company's flexImaging visualization and image processing software. Bruker Daltonics Inc., Billerica, MA; www.bdal.com
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Explosives trace detection
Syagen's Guardian explosives trace detection portal uses mass spectrometry, reportedly offering higher resolution than ion mobility spectrometry portals. The system can detect more than 30 explosives compounds, and compounds can be simultaneously screened. It features head-to-toe screening, an analysis time less than 15 s, and clear doors. Syagen Technology, Inc., Tustin, CA; www.syagen.com
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LC–MS system
The NanoFrontier LC–MS system from Hitachi combines a linear ion trap with TOF detection. The system features the company's NanoFrontier nLC capillary chromatograpy system that reportedly provides gradient and retention time reproducibility at a 50-nL/min flow rate. Hitachi High Technologies America, San Jose, CA; www.hitachi-hta.com
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Nano flow sensor
Upchurch's noninvasive nano flow sensor, developed in cooperation with Honeywell, reports flow rates in the nanoliter through low microliter-per-minute range. According to the company, the sensor uses MEMS-based thermal anemometry to measure the mass-flow rate of liquids in an isolated flow channel and display it on an LCD readout. The sensor reportedly provides high sensitivity, ultrafast response, high accuracy, and low drift. Upchurch Scientific, Oak Harbor, WA; www.upchurch.com
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Ionization source
MassTech's AP/MALDI atmospheric pressure MALDI source creates ions at atmospheric pressure instead of under vacuum. The source uses a UV laser to irradiate samples consisting of cocrystallized matrix and analyte. MassTech, Inc., Columbia, MD; www.apmaldi.com
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MS analyzer
The TriVersa NanoMate MS system from Advion combines LC–MS, fraction collection, and ESI chip-based infusion. The system is designed for a wide range of analyses including biomarker discovery, metabolity identification, protein identification, posttranslational modification analysis, lipidomics, top down analyses, and noncovalent interaction research. It is compatible with columns ranging in size from 75 µm to 4.6 mm. Advion BioSystems, Ithaca, NY; www.advion.com
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ICP-MS systems
Two ICP-MS instruments from Varian are designed for elemental analysis of complex samples. The model 810-MS and 820-MS instruments contain high-efficiency 90-degree ion optics and a double off axis quadrupole designed to provide low background noise and gigahertz sensitivity. The model 820-MS also includes the company's collision reaction interface, which reportedly enables the use of collision and reaction gases such as helium, allowing lower detection limits and more accurate quantitation for difficult elements in complex samples. Varian, Inc., Palo Alto, CA; www.varianinc.com
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Refractive index and fluorescence detectors
Thermo Electron's Surveyor Plus refractive index and fluorescence detectors are designed to be integrated with the company's Finnigan Surveyor Plus HPLC systems. The refractive index detector is suitable for detecting compounds lacking chromaphores, such as alcohols, fatty acids, and esters. The fluorescence detector monitors emissions of fluorescence, phosphorescence, and chemiluminescence, and analyzes polyaromatic hydrocarbons, derivatized amino acids, carbamates, and glyphosates. Thermo Electron Corp., Waltham, MA; www.thermo.com
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Ion optical grids
ETP Electron Multipliers' ion optical grids are designed to facilitate the high-speed performance of the company's TOF detectors. The grids also can be used with general ion and electron optics. Other applications include field isolation and termination elements in both linear and reflectron instruments. The wires of the standard grid are 18-µm tungsten at a pitch of 250 µm, reportedly giving a transmission of 92%. SGE, Inc., Austin, TX; www.etpsci.com
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Software
Applied Biosystems' MarkerView software is designed for metabolomics and biomarker profiling analysis. The software reportedly allows researchers to analyze MS data sets for changes in protein, peptide, and metabolic patterns resulting from disease, drug treatment, or drug toxicity. The software is compatible with all Applied Biosystems and MDS SCIEX mass spectrometers, including both MALDI and ESI instruments. Applied Biosystems, Foster City, CA. www.appliedbiosystems.com
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Electron multiplier
BURLE Electro-Optics' 5905 MAGNUM detector is designed to provide high dynamic range, increased gain stability, and near elimination of feedback noise. A proprietary glass formulation reportedly facilitates long detector life. The detector is designed specifically for Thermo Finnigan mass spectrometers; the electron multiplier cartridge is a plug-in replacement that fits directly in to the Thermo Finnigan mounting assembly. Its one piece construction eliminates fastener and connection problems. BURLE Electro-Optics, Sturbridge, MA; www.burle.com
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Power supply
A 5-V input power option for EMCO's CA power supplies is intended for designers with 5-V circuits to eliminate the need for a secondary 12- or 24-V output power source. According to the company, the power supplies feature ripple as low as 5 ppm peak to peak; a temperature coefficient of less than 25 ppm/°C; an on-board precision reference and precision output voltage monitor; low EMI/RFI emissions and arc; and overload and short circuit protection. EMCO High Voltage Corp., Sutter Creek, CA; www.emcohighvoltage.com
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SFC–MS system
Thar offers its SFC–MS Resolution system, a combination of the company's supercritical fluid chromatography system with Waters' Micromass ZQ mass detector. The unit features Waters MassLynx/OpenLynx software for complete control over the SFC–MS system. Thar Technologies, Inc., Pittsburgh, PA. www.thartech.com
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Derivatization reagent
A derivatization reagent from Regis Technologies, 3 N hydrochloric acid in butanol, is used for newborn metabolic screening by tandem MS. According to the company, production under cGMP protocols ensures lot-to-lot consistency. The reagent is available in a variety of packaging types. Regis Technologies, Inc., Morton Grove, IL; www.registech.com
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Mass Spectrometer
The Agilent 6410 Triple Quad mass spectrometer is designed for femtogram-level sensitivity. It features a parameter-free integrator in the data analysis software that automatically calculates quantity and a single point of software control for both LC and MS instruments. Agilent Technologies, Palo Alto, CA; www.agilent.com
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High-voltage module
Spellman High Voltage introduces the model MX10 high-voltage module for mass spectrometry. The DC-DC converter features hot switchable polarity reversal at 10 kV between 100 and 250 ms, and low peak-to-peak ripple performance. Applications include security detection systems, LC–TOF dynodes, sample ionization, as well as capillary electrophoresis and electrostatic printing. Spellman High Voltage, Hauppauge, NY. www.spellmanhv.com
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LC–MS gas generation system
Parker Balston introduces the SOURCE LCMS-5000 LC-MS gas generation system, which produces nitrogen, zero air, and exhaust pump gases. It combines a compressor with coalescing filters, catalysts, and hollow-fiber membranes to produce these gases. Parker Hannifin Corporation, Haverhill, MA; www.parker.com
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Dry vacuum pump
The XDS35i dry vacuum pump from BOC Edwards offers a dry, oil-free vacuum pump design. A bearing shield isolates the bearings and bearing grease from the vacuum environment. The pump is driven from single-phase power with an inverter that reportedly provides a constant pumping speed of 35 m3/hr at frequencies of 50 or 60 Hz. BOC Edwards, Inc., Wilmington, MA; www.bocedwards.com
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Electron multipliers
The CERAMAX 7000 Series of ceramic channel electron multipliers from ITT Power Solutions is designed for mass spectrometry and other applications. Their monolithic ceramic construction and advanced ion-optical design reportedly yields improvements over conventional detectors including low noise, increased linear dynamic range, enhanced sensitivity and longer life. Many models include the company's Snap-In/Snap-Out mounting hardware, which is designed to speed future multiplier replacement and ensure perfect ion-optical alignment. According to the company, the multiplier can be installed quickly without tools or training. ITT Power Solutions, Inc., West Springfield, MA; www.kandm.com
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Machine shop facility
Scientific Instrument Services's new 10,000 square foot machine shop facility contains computer controlled lathes, mills, screw machines, and other metal machining equipment. With the facility, the company plans to expands its custom and OEM machining and manufacture of precision parts for scientific, medical, and industrial markets. Scientific Instrument Services, Ringoes, NJ; www.sisweb.com
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Mass spectrometer
Thermo Electron's LTQ Orbitrap hybrid mass spectrometer is designed for small molecule research, drug discovery, proteomics, metabolite identification, and metabolomics. According to the company, the instrument provides intensity-independent mass accuracy and requires no internal calibration. Thermo Electron, Waltham, MA; www.thermo.com
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UPLC/MS system
Waters' ACQUITY SQD Ultra Performance LC–MS system is designed to provide information about the identity of pharmaceutical, biological, industrial, and environmental compounds. The system features the company's SQ detector, a single-quadrupole, atmospheric pressure ionization mass detector. The detector has scanning speeds of up to 10,000 amu/s and is 40% smaller than its predecessor. Waters Corporation, Milford, MA; www.waters.com
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