Molecular Spectroscopy

A recent study examined the interaction mechanism between methylene blue (NMB) and human serum albumin (HSA) and bovine serum albumin (BSA).

This year’s recipient of the Coblentz Award, Wei Xiong of the University of California, San Diego, is being honored for his work. Spectroscopy spoke to Xiong about his work and his feelings about receiving this award.

Shifted-excitation Raman difference spectroscopy (SERDS) is a technique that is capable of reducing the interference caused by fluorescence and improve the potential of Raman for distinguishing drug compounds in seized samples with fluorescent additives. Here, 43 drugs were analyzed to show the practical application of SERDS.

Author Jean-Pierre P. de Vera talks to Spectroscopy magazine about his study in which seven biomolecules were exposed to a simulated Martian environment outside the International Space Station (ISS) for a period of approximately 15 months.

The detection of life on other planets is a research area of focus for scientists in space exploration. In this Q&A, Andreas Riedo of the Physics Institute at the University of Bern offers his thoughts on how spectroscopy is being used to detect organic molecules that are relevant for life.

A Nature study reports the discovery of diverse organic-mineral associations in the Máaz and Séítah formations within Jezero crater on Mars, as observed by the Perseverance rover's SHERLOC instrument. The Raman and fluorescence findings indicate the presence of aromatic organic molecules within Martian soils.

The study of exoplanets, or planets outside of our solar system, is becoming increasingly important in space exploration. Scientists are working to characterize these planets and Raman spectroscopy is playing a key role. Andrew Mattioda, a research scientist at the National Aeronautics and Space Administration (NASA) Ames Research Center, is on the front lines of this research.

Researchers have developed a non-destructive method for identifying monoclonal antibody drug substances using Raman spectroscopy.

Researchers explore the antioxidant potential of Corema album (L.) D. Don by conducting a spectrochemical analysis on its leaf extracts. The study uncovers seasonal and sexual variations in antioxidant activity and phenolic compound composition, providing valuable insights for harnessing the bioactive properties of this plant species.

Researchers delve into the interaction between calf thymus DNA and an anticancer platinum (Pt) complex, uncovering its binding mechanism through spectroscopy and molecular dynamic simulations, offering valuable knowledge for future therapeutic advancements.

Researchers identify osmundacetone as a strong inhibitor of xanthine oxidase, revealing its interaction mechanism and paving the way for the development of novel uric acid-related disorder treatments.

Researchers have developed a selective fluorescent probe, derived from flavone derivatives, called FlaN-DN for hydrogen sulfide (H2S) detection and intracellular imaging.

This study provides insights into the alternative use of barochromic studies for determining the polarizability of organic molecules in excited states.

A research team has designed and synthesized two fluorescent sensors, CAA and CAB, for fluorescence detection of copper ion (Cu2+) and formaldehyde.

Researchers have developed a novel fluorophore, diaryl maleimide (DAM), with multichromic properties potentially useful for volatile vapor detection in LED lighting systems, showcasing its versatility and applications in sensing technologies.

A new study has been conducted on the phase transitions in 1-adamantylamine and 1-adamantanol. Through various experimental techniques, they revealed the nature of these transitions, including changes in dielectric properties and sensitivity to pressure, providing valuable insights into the behavior of these compounds.

A scientific team has developed a two-photon phosphorescent probe, Ir-CN, for the sensitive detection of sulfur dioxide derivatives in living cell mitochondria.

A new study reveals the potential of Raman spectroscopy in recognizing nucleophosmin (NPM1) mutant gene expression in leukemia cells.

Researchers have developed microbiological and spectrophotometric methods for the quantitative determination of tioconazole, an antifungal drug, providing valuable tools for the analysis and quality control of tioconazole in pharmaceutical preparations.

Researchers have developed a novel near-infrared fluorescent probe, FNIR-pH, that allows sensitive detection of mitochondrial pH and study of mitophagy, revealing cellular health and disease processes.

Serum Raman spectroscopy combined with a convolutional neural network (CNN) offers a highly accurate and noninvasive method for diagnosing gastric, colon, rectal, and lung cancers paving the way for improved cancer screening and early detection.

A recent study reveals the pressure-induced phase transitions in imidazolium manganese-hypophosphite hybrid perovskite using Raman spectroscopy.

Scientists have developed a fluorescent sensor via a surface ion imprinting rice husk-based polymer capable of selectively detecting and efficiently adsorbing copper ions from lake water.

Researchers have conducted a preliminary study on the potential use of near-infrared (NIR) and Raman spectroscopy for predicting ice cream mix viscosity. The study highlights the promising performance of NIR spectroscopy and serves as a starting point for further investigations into in situ application of these analytical tools in the ice cream manufacturing process.

A new study demonstrates the improved accuracy of depth profiling in confocal Raman microscopy for analyzing the structural and chemical composition of polymeric microsphere layers.

Researchers have developed a near-infrared fluorescent probe that allows for highly sensitive detection of butyrylcholinesterase activity and pesticide residue in food samples. The probe offers a ratiometric pattern and shows promise for applications in health evaluation, disease diagnosis, and environmental monitoring.

Raman spectroscopy has the capability of accurately determining the physical and chemical properties of bioplastics (polyhydroxybutyrate hexanoate [PHBHx]), which helps determine the maximum crystallinity a polymer can experience.

Double metal cyanide (DMC) can be monitored in real time using an in situ Raman spectroscopy method. In this study, real-time reaction progress information from in situ Raman results enabled researchers to accurately determine the reaction end point of DMC.

Determining the printing sequences of crossed writings and seal stamps is often difficult because the most common methods used are expensive, time-consuming, and cumbersome. A new method using Raman spectral area scanning offers a better alternative while conducting pigment analysis and determining intersection sequences of writings and seal stamps. We explain why.

Detecting illicit drugs in blood samples requires a rapid, non-invasive technique. The combination of surface-enhanced Raman spectroscopy (SERS) and chemometric techniques, such as principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA), can aid in this endeavor.