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ADME/Tox Profiling Using Coulometric Electrochemistry and Electrospray Ionization Mass Spectrometry (PDF)The authors discuss the use of serial coulometric flow cells coupled online with electrospray ionization mass spectrometry in predictive assays for absorption, distribution, metabolism, excretion, toxicity (ADME/Tox), and stability implemented at early stages of drug discovery.
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Development of a High-Throughput LC–MS-MS Assay for 13 Commonly Prescribed Pain Management Drugs from Urine with Cleanup Using Solid-Phase ExtractionFast turnaround time is critical in the clinical testing environment. Here, fast liquid chromatography (LC) technologies were utilized for the comprehensive assay of commonly prescribed pain management drugs in under 2 min. The use of fast LC also provided significantly improved sensitivity. A mini-validation for these analytes in human urine was performed and acceptable values for accuracy, precision, linearity, lot-to-lot variability, and matrix effects were demonstrated for each analyte.
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Smart Oxygen Cuvette for Optical Monitoring of Dissolved Oxygen in Biological Blood SamplesA "Smart" Oxygen Cuvette has been developed by coating the inner surface of a plastic (PMMA) cuvette with sol-gel based oxygen-sensitive indicator material. This new oxygen sensing system monitors the dissolved oxygen in samples for biological and medical applications.
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Nontargeted Screening and Accurate Mass Confirmation of Pesticides Using High-Resolution LC–Orbital Trap Mass SpectrometryThe increasing use of pesticide testing coupled with reductions in maximum permissible residue levels of pesticides in food have driven demand for fast, sensitive, and cost-effective analytical methods for high-throughput screening of multiclass pesticides in food. Detection of 510 pesticides at low parts-per-billion levels can be achieved within minutes using orbital trap technology. The high resolving power of these systems enables accurate mass confirmation of all compounds, including isobaric pesticides. This article will provide an overview of current legislation and illustrate how mass spectrometry instrumentation can enable fast and accurate pesticide screening.
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Application of Microbore UHPLC–MS-MS to the Quantitation of In Vivo Pharmacokinetic Study SamplesIn this article, the authors discuss the advantages of using a microbore UHPLC system coupled with a tandem mass spectrometer for the quantitation of in vivo pharmacokinetic samples.
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Branching Out: Mass Spectrometry and the Shape of BiotherapeuticsThose fond of puns point out that mass spectrometry (MS) has become ever more focused in the last two decades, while at the same time offering ever more information. The dynamic market for biotherapeutics has driven a number of developments, particularly following the paradigm of well-characterized biopharmaceutical products (WCBP) (1,2). Partly as a result of automation and interfacing, those trained in biological or biochemical disciplines now use mass spectrometers routinely. This also means that the sorts of questions asked of MS have changed. Coping with biomolecule heterogeneity is a key challenge, not generally an issue for small molecule drugs. The data complexity means that mass information alone is insufficient. And at the submission stage, regulators are increasingly concerned about tertiary structure and conformation, something that was not previously an analytical requirement (2). Adding polyethylene glycol (PEG) to already heterogeneous molecules to prolong their half-lives in the body raises..
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Error Terror in Forensic Science: When Spectroscopy Meets the CourtsA big question in forensic science today is, “How do we best report uncertainty?” The answer to which approach is “best” turns out to be surprisingly complex, for many reasons.
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Improving Biofuel Production Through Feedstock Screening With ICP-OESInductively coupled plasma optical emission spectrometry (ICP-OES) is the preferred technique for inorganic contaminant analysis of biodiesel, and PerkinElmer offers two technologies to support it. The Avio 220 Max and Avio 550 Max, combined with PerkinElmer's expertise, can help labs achieve accurate feedstock analysis demanded by today's market.
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Improving the Analytical Workflow for Protein Biopharmaceutical Characterization with a Novel LC–MS System SolutionThis article presents an efficient analytical workflow for protein characterization using LC–MS.
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The Application Notebook - A Stable Force Over the YearsApplication notes are a great opportunity for suppliers to inform the scientific marketplace about the latest applications and areas of method development.
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Optimizing Discrete Dynodes for Improved Performance and Lifetime// You can adjust the form size here: var DrupalLeadsFormWidth = 870; var DrupalLeadsFormHeight = 2500;
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Determining High-Molecular-Weight Phthalates in Sediments Using GC–APCI-TOF-MSGas chromatography combined with atmospheric-pressure chemical ionization (APCI) was used to analyze high-molecular-weight phthalates.
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Analysis of Drug Eluting Stent Coating Solutions Using FT-NIR SpectroscopyA drug-eluting stent (DES) is an expandable metal alloy framework placed into narrowed coronary arteries that slowly releases a drug coating to treat atherosclerosis. Production of DES is a labor-intensive batch process that requires very tight control. Fourier Transform Near-InfraRed spectroscopy (FT-NIR) is an efficient technique to perform accurate quantification of the different components in DES coating solutions.
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FT-IR gas analysis of coal-to-ethylene glycol processCoal-to-ethylene glycol is the process by which ethylene glycol is synthesized from coal instead of traditional methods using petroleum as the raw material. This study demonstrates that Fourier Transform Infrared Spectroscopy (FT-IR) can be a reliable alternative to simultaneously measure methyl nitrite and other process gases (such as CO and NO) using a single ABB analyzer.
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Laser Ablation Molecular Isotopic Spectrometry for Rare Isotopes of the Light ElementsThis article describes measurements of isotopes of hydrogen, boron, carbon, nitrogen, oxygen, and chlorine using laser ablation molecular isotopic spectrometry (LAMIS).
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Determination of Low Concentration Methanol in Alcohol by an Affordable High Sensitivity Raman InstrumentLow concentration natural methanol exists in most alcoholic beverages and usually causes no immediate health threat.
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Reduction of Carbon-Based Interferences in Organic Compound Analysis by Dynamic Reaction Cell ICP MS (PDF)The authors show that dynamic reaction cell ICP MS can eliminate a number of argon- and carbon-based polyatomic interferences, allowing the determination of many critical elements in problematic organic compounds found in the semiconductor industry.
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High Resolution 1H NMR Spectroscopy of Metabolically Active Microorganisms Using Non-Destructive Magic Angle Spinning (PDF)The authors show that high resolution 1H nuclear magnetic resonance (NMR) spectroscopy can be used to study biofilm metabolism under environmentally relevant conditions in a minimally invasive way.
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Bioanalysis Using Dried Blood Spots: The Biggest Advancement in Bioanalysis Since LC–MS-MS?The collection of blood-derived samples from preclinical and clinical trial studies onto paper-based, Guthrie-type cards is gaining momentum within the pharmaceutical industry. This approach holds the potential to minimize animal usage, improve data quality, and reduce shipping costs. However, the small sample volumes and extra matrix effects from the cards result in method development and sensitivity challenges for bioanalysts. Here, we present a discussion on the analytical challenges that both liquid chromatography and mass spectrometry face as well as present some potential solutions to these issues.
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Bioanalysis Using Dried Blood Spots: The Biggest Advancement in Bioanalysis Since LC–MS-MS?The collection of blood-derived samples from preclinical and clinical trial studies onto paper-based, Guthrie-type cards is gaining momentum within the pharmaceutical industry. This approach holds the potential to minimize animal usage, improve data quality, and reduce shipping costs. However, the small sample volumes and extra matrix effects from the cards result in method development and sensitivity challenges for bioanalysts. Here, we present a discussion on the analytical challenges that both liquid chromatography and mass spectrometry face as well as present some potential solutions to these issues.
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Quo Vadis Regulated NIR Analytical Procedures?Some parts of the FDA’s new draft guidance for Development and Submission of NIR Analytical Procedures are reviewed and critiqued. What’s in it for spectroscopists?
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Peptide Mapping of Monoclonal Antibodies and Antibody–Drug Conjugates Using Micro-Pillar Array Columns Combined with Mass SpectrometryThe structural complexity of monoclonal antibodies (mAbs) challenges the capabilities of even the most advanced chromatography and mass spectrometry techniques. This study examines the use of micro-pillar array columns in combination with mass spectrometry for peptide mapping of both mAbs and antibody–drug conjugates (ADCs).
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Determination of Low Concentration Methanol in Alcohol by an Affordable High Sensitivity Raman InstrumentLow concentration natural methanol exists in most alcoholic beverages and usually causes no immediate health threat.
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Quantitative Proteomic Workflow for Discovery of Early Rejection Kidney Transplant Peptide Biomarkers and Subsequent Development of SRM Assays in UrineThe authors discuss a noninvasive method for determining early indications of the rejection of a kidney transplant.
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PittCon 2002 Review (PDF)Spectroscopy's annual overview of new instrumentation presented at the PittCon conference.
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Applications of 1064 nm Dispersive Raman Systems in Biofuel ResearchBaySpec, Inc. has developed a complete line of 1064 nm excitation, dispersive Raman systems that offer maximum reduction in fluorescence interference from biological samples and thus making them very useful tools for biofuel research.
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The Use of Novel Software for the Identification of Trace Compounds in Complex MixturesMany volatile organic compounds (VOCs) found in a variety of consumer products are potentially harmful to human health and the environment. Within industry, to regulate product safety and quality, methods for measuring specific VOCs in a product, typically by thermal desorption gas chromatography–mass spectrometry (TD-GC–MS), are implemented. Such analysis provides a comprehensive VOC profile. However, the nature of some products, such as food, can be chemically complex. Within this complexity, trace-level or coeluting compounds can be difficult or time-consuming to identify. As a potential solution, new software tools are being developed to automate interpretation of the data.
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Deep Ultraviolet MeasurementsUltraviolet (UV) spectrophotometry has a well-deserved niche. Many UV-Vis instruments claim to work to the deep UV. Few instruments optimize for, or cater to, the 120 to 400 nm region. Development and manufacture of ultraviolet lasers, optics, crystalline materials, and resonance Raman instruments, as well as basic research, require a broadly useful instrument for analysis, characterization, and test. Enter McPherson's Vacuum Ultraviolet Analytical Spectrophotometer (VUVAS.)
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A Statistical Approach to Reporting Uncertainty on Certified Values of Chemical Reference Materials for Trace Metal Analysis (PDF)The authors discuss an approach by a manufacturer of calibration standards and certified reference materials to standardize the reporting of uncertainty associated with certified values quoted on a certificate of analysis.
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High-Resolution Ultrasonic Spectroscopy: Analysis of Microemulsions (PDF)This article introduces the application of high-resolution ultrasonic spectroscopy for the analysis of emulsions and suspensions.
