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Diamond ATR-FTIR Study of NitrilesDiamond ATR has become one of the most commonly used FT-IR spectroscopy methods. However, the strong diamond lattice bands in the 2300–1900 cm-1 region make it difficult to measure the functional groups from nitriles, isocyanates, isothiocyanates, diimides, azides, and ketenes that would normally appear in that region. This applications note compares the sensitivity of a single-reflection ATR to multiple-reflection ATR for the nitrile functional group infrared transition.
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Application of Microbore UHPLC–MS-MS to the Quantitation of In Vivo Pharmacokinetic Study SamplesIn this article, the authors discuss the advantages of using a microbore UHPLC system coupled with a tandem mass spectrometer for the quantitation of in vivo pharmacokinetic samples.
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A Sensitive, Specific, Accurate, and Fast LC–MS-MS Method for Measurement of 42 Ethyl Glucuronide and Ethyl Sulfate in Human UrineA method is illustrated for the simultaneous analysis of ethyl glucuronide and ethyl sulfate in human urine samples.
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FT-IR Contaminant Identification Using OMNIC? Specta SoftwareIdentifying contaminants in materials is a common troubleshooting need for which FT-IR spectroscopy is ideally suited. Thermo Scientific OMNIC Specta software provides a unique and powerful tool to assist the analyst to quickly identify unexpected constituents. The OMNIC? Specta? Contaminant Search feature allows for rapid investigations that can save time and minimize the impact of product issues.
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The Application Notebook - A Stable Force Over the YearsApplication notes are a great opportunity for suppliers to inform the scientific marketplace about the latest applications and areas of method development.
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Fast Multidimensional NMR Spectroscopy by the Projection-Reconstruction Technique (PDF)The authors describe a new method for making faster measurements of multidimensional NMR spectra. The technique involves acquiring a small number of projections and using them to reconstruct the entire spectrum.
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A New Outlook on Soft Ionization for GC–MSDespite the advantages of soft ionization ion-source technologies for improving confidence in the identification of a range of challenging analytes, soft ionization remains a niche technique for gas chromatography–mass spectrometry (GC–MS).
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Detecting Methanol Contamination in Hand SanitizersThis case study demonstrates how the Tactic-ID GP handheld Raman analyzer was used to detect contamination in a commercial hand sanitizer.
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Branching Out: Mass Spectrometry and the Shape of BiotherapeuticsThose fond of puns point out that mass spectrometry (MS) has become ever more focused in the last two decades, while at the same time offering ever more information. The dynamic market for biotherapeutics has driven a number of developments, particularly following the paradigm of well-characterized biopharmaceutical products (WCBP) (1,2). Partly as a result of automation and interfacing, those trained in biological or biochemical disciplines now use mass spectrometers routinely. This also means that the sorts of questions asked of MS have changed. Coping with biomolecule heterogeneity is a key challenge, not generally an issue for small molecule drugs. The data complexity means that mass information alone is insufficient. And at the submission stage, regulators are increasingly concerned about tertiary structure and conformation, something that was not previously an analytical requirement (2). Adding polyethylene glycol (PEG) to already heterogeneous molecules to prolong their half-lives in the body raises..
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Portable Transmission FTIR Analysis of Volatile Samples Using the DialPath Liquid CellTraditionally the analysis of volatile liquids by FTIR spectroscopy has always entailed a sealed fixed pathlength cell.
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Using Comprehensive GC×GC–TOF-MS for Enhanced Detection and Separation in Antidoping Control ScreeningThe misuse of androgenic anabolic steroids in sports was banned in 1976 by the International Olympic Committee and global sports community. The illegal use of anabolic steroids has reached disturbing levels worldwide. This worldwide problem is fueled partially by an ever-increasing demand for better athletic performance. The World Anti-Doping Agency has formulated strict guidelines for minimum allowable concentrations of exogenous anabolic steroids and their metabolites. The standard test methods for doping control are analyzed in urine samples with trimethyl-silyl derivatization. Urine is a complex and difficult biological matrix. This research shows the advantages of using comprehensive two-dimensional gas chromatography–time-of-flight-mass spectrometry (GCÃ-GC–TOF-MS) and illustrates the capability of GCÃ-GC-TOF-MS to be an effective instrumental option for antidoping control screening.
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Branching Out: Mass Spectrometry and the Shape of BiotherapeuticsThose fond of puns point out that mass spectrometry (MS) has become ever more focused in the last two decades, while at the same time offering ever more information. The dynamic market for biotherapeutics has driven a number of developments, particularly following the paradigm of well-characterized biopharmaceutical products (WCBP) (1,2). Partly as a result of automation and interfacing, those trained in biological or biochemical disciplines now use mass spectrometers routinely. This also means that the sorts of questions asked of MS have changed. Coping with biomolecule heterogeneity is a key challenge, not generally an issue for small molecule drugs. The data complexity means that mass information alone is insufficient. And at the submission stage, regulators are increasingly concerned about tertiary structure and conformation, something that was not previously an analytical requirement (2). Adding polyethylene glycol (PEG) to already heterogeneous molecules to prolong their half-lives in the body raises..
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Lithium-Ion Battery Analysis: A Virtual SymposiumWebinar Date/Time: Thursday, September 26, 2024 Morning Session: 10:00 AM EDT | 7:00 AM PDT | 3:00 PM BST | 4:00 PM CEST Afternoon Sesson: 12:30 PM EDT | 9:30 AM PDT | 5:30 PM BST | 6:30 PM CEST
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Liquid Chromatography–Time-of-Flight Mass Spectrometry for Cannabinoid Profiling and Quantitation in Hemp Oil ExtractsThe method presented here allows for the accurate, precise, and robust speciation, profiling, and quantification of cannabinoids in hemp oil extracts and commercial cannabinoid products for research and development laboratories.
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Using Headspace Gas Chromatography for the Measurement of Water in Sugar and Sugar-Free Sweeteners and ProductsThis fast, automated method was shown to be accurate and precise for 16 liquid sweeteners, and is likely more accurate than Karl Fischer titration.
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Comparing the Capabilities of Time-of-Flight and Quadrupole Mass SpectrometersThe authors explain some of the primary differences between quadrupole and time-of-flight mass analyzers and provide information regarding the benefits of each in their use for gas chromatography applications.
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Chemical Analysis of Microscopic Fluorescent Materials by Dispersive 1064 Raman SystemRaman measurement on microscopic inclusions in fluorescent materials requires the ability to measure in small volumes, excellent throughput, and long wavelength excitation such as 1064 nm for fluorescence reduction.
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Determination of Low Concentration Methanol in Alcohol by an Affordable High Sensitivity Raman InstrumentLow concentration natural methanol exists in most alcoholic beverages and usually causes no immediate health threat.
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Nontargeted Screening and Accurate Mass Confirmation of Pesticides Using High-Resolution LC–Orbital Trap Mass SpectrometryThe increasing use of pesticide testing coupled with reductions in maximum permissible residue levels of pesticides in food have driven demand for fast, sensitive, and cost-effective analytical methods for high-throughput screening of multiclass pesticides in food. Detection of 510 pesticides at low parts-per-billion levels can be achieved within minutes using orbital trap technology. The high resolving power of these systems enables accurate mass confirmation of all compounds, including isobaric pesticides. This article will provide an overview of current legislation and illustrate how mass spectrometry instrumentation can enable fast and accurate pesticide screening.
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Ingredient-Specific Particle Sizing of Aerosolized Nasal Spray* Using Wide-Field Raman Chemical ImagingRaman Chemical Imaging technology is able to identify and differentiate multiple components in complex formulated nasal spray suspensions based on chemical makeup. Particle size distribution statistics for the ingredient of interest are produced in a rapid, objective and semi-automated manner. Both solitary and aggregated drug particle sizing information may be obtained.
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Nontargeted Screening and Accurate Mass Confirmation of Pesticides Using High-Resolution LC–Orbital Trap Mass SpectrometryThe increasing use of pesticide testing coupled with reductions in maximum permissible residue levels of pesticides in food have driven demand for fast, sensitive, and cost-effective analytical methods for high-throughput screening of multiclass pesticides in food. Detection of 510 pesticides at low parts-per-billion levels can be achieved within minutes using orbital trap technology. The high resolving power of these systems enables accurate mass confirmation of all compounds, including isobaric pesticides. This article will provide an overview of current legislation and illustrate how mass spectrometry instrumentation can enable fast and accurate pesticide screening.
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Ultralow Detection of Estrogenic Compounds by GC–NCI-MS-MSA number of clinical situations now call for high-sensitivity measurement of estrogens, including monitoring during female hormone replacement therapy, antiestrogen treatment, and estrogen deficiency in men. Traditional immunoassay methods and liquid chromatography–tandem mass spectrometry (LC–MS-MS) do not provide the sensitivity and selectivity required for these applications. In contrast, a gas chromatography–negative chemical ionization–tandem mass spectrometry (GC–NCI-MS-MS) platform can provide detection limits below 1 pg/mL when used in conjunction with the appropriate derivatization protocol, with very short cycle times.
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Quantitative Proteomic Workflow for Discovery of Early Rejection Kidney Transplant Peptide Biomarkers and Subsequent Development of SRM Assays in UrineThe authors discuss a noninvasive method for determining early indications of the rejection of a kidney transplant.
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Mid-infrared Microspectroscopy of Difficult Samples Using Near-Field Photothermal Microspectroscopy (PTMS) [PDF]The authors discuss progress in near-field IR microspectroscopy using a photothermal probe and show how it can be applied to the spectroscopic characterization of real-world samples.
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Miniaturized MIR and NIR Sensors for Medicinal Plant Quality ControlThis work shows that methods based on miniaturized near- and mid-infrared spectroscopy can be used effectively for the quality control of herbal medicines.
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Advantages of High OD Filters to MicroscopyThe use of filters in optical microscopy has become so commonplace that it is hard to find a biological microscope that does not have some type of filter accessory kit. For particular modalities, such as two-photon imaging, the use of optical filters is essential to make the method viable. Filter technology has progressed steadily over the past few decades, moving away from simple colored glass filters to complicated thin-film–based optical components. With optical densities commonly reaching values of 4 or greater, spectrally selective imaging has never been more accurate.
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Analysis of Organic Compounds in Water Using Unique Concentration–Injection Techniques for Portable GC–MSA simple method for extraction and concentration of trace organic compounds found in water for gas chromatography-mass spectrometry (GC-MS) analysis was developed. The method used 25 and 45 mL glass vials with a 5-10 µm thick polymer coatings for extraction of analytes from 20 and 40 mL water samples, respectively. Analytes were subsequently transferred from the polymer coating into an organic solvent, which was reduced in volume to 200-400 µL for analysis. A 10-20 µL sample from the vial was transferred to a tiny coiled stainless steel wire filament using a micro-syringe, or by dipping the coil into the sample. After air evaporation of the solvent, the coil was inserted into the heated injection port of a portable GC-MS system where the analytes were desorbed. Injection using the coiled wire filament eliminated sample discrimination of high boiling point compounds, and minimized system contamination caused by sample matrix residues. The GC-MS contained a new resistively heated column bundle that allowed elution of low-volatility compounds in less than 4 min. Analyses of organochlorine pesticides, polycyclic aromatic hydrocarbons, polychlorinated biphenyl congeners, pyrethroid insecticides, phthalate esters, and n-alkanes in water and wastewater samples were accomplished for low ppb concentrations in less than 10 min total analysis time.
