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Peptide Mapping of Monoclonal Antibodies and Antibody–Drug Conjugates Using Micro-Pillar Array Columns Combined with Mass SpectrometryThe structural complexity of monoclonal antibodies (mAbs) challenges the capabilities of even the most advanced chromatography and mass spectrometry techniques. This study examines the use of micro-pillar array columns in combination with mass spectrometry for peptide mapping of both mAbs and antibody–drug conjugates (ADCs).
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Application of Unique Software Tools Dedicated to Multiline Analysis by CCD-Based ICP-AES for Geological SamplesMultiline analysis, which consists of using several lines per element to detect positive or negative bias caused by spectral interferences, is an ideal way to use all the information emitted by the plasma and collected by a charge-coupled device detector. However, method development and validation become more complex. Dedicated software has been developed to overcome it, and analysis of geological samples will illustrate their benefit in achieving high reliability of results.
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ICP-MS: A Universally Sensitive GC Detection Method for Specialty and Electronic Gas AnalysisThe authors discuss the use of ICP-MS as an effective chromatographic detection method that is relatively easy to interface to gas chromatography for gas analysis.
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Spatial Resolution in IR Reflectance Imaging — NIR, Mid-IR, and ATRWhen images are measured in reflectance, the observed structure is not necessarily just that of the sample surface.
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A Sensitive, Specific, Accurate, and Fast LC–MS-MS Method for Measurement of 42 Ethyl Glucuronide and Ethyl Sulfate in Human UrineA method is illustrated for the simultaneous analysis of ethyl glucuronide and ethyl sulfate in human urine samples.
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Ultratrace Aluminum Analysis of Nutritional Intravenous Solution Components in 1-Propanol Using GFAAS (PDF)This article describes how ultratrace aluminum analysis of two nutritional intravenous solution components with limited water solubility can be performed by graphite furnace atomic absorption spectroscopy (GFAAS) with dissolution in 1-propanol.
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Analysis of Small Molecules with amaZon: Enhanced Sensitivity, Speed, and Dynamic RangeThe amaZon series is the next step in Bruker Daltonics' family of ion trap mass spectrometers.
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A Simplified Approach to Optimize SPE Method Development with Downstream LC–MS Analysis Allowing 100% Organic, Basified Injection SolventsHere, the authors demonstrate the use of a systematized approach to SPE method development and LC–MS-MS analysis.
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SERS Comes of Age for Molecular DetectionSince it was first described in 1974, surface-enhanced Raman spectrometry (SERS) has been thought to offer significant potential for a range of different applications. The theoretical sensitivity and specificity envisaged for this powerful technique has engaged scientists for many years, but practical challenges have hindered its routine adoption. Now, a new approach combines a robust and reliable substrate with expertise in surface chemistry and molecular biology on a platform that can be adapted for a wide variety of Raman instrumentation and customized routine applications.
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Investigation of Transferrin Structure via Novel Electron Capture Dissociation Techniques Using a Hybrid Linear Ion Trap Time-of-Flight Mass SpectrometerThe authors discuss the use of electron-capture dissociation coupled with a linear ion trap time-of-flight mass spectrometer to investigate the structure of human transferrin.
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Study Emulsions Using the inVia Confocal Raman MicroscopeThe study of emulsions is important to provide information on interactions, separation, network connections and the role of emulsifiers. These are key to ensure emulsion is stable and suited to its specific role.
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Interaction of Dichloromethane Solvent with n-Alkylamines Analyzed by Electron Ionization GC–MSThe analysis of amines by gas chromatograph ;mass spectrometry (GC–MS) using electron ionization (EI) has always been a challenge
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Current Status of Standoff LIBS Security Applications at the United States Army Research LaboratoryThe United States Army Research Laboratory (ARL) has been applying standoff laser-induced breakdown spectroscopy (LIBS) to hazardous material detection and determination. We describe several standoff systems that have been developed by ARL and provide a brief overview of standoff LIBS progress at ARL. We also present some current standoff LIBS results from explosive residues on organic substrates and biomaterials from different growth media. These new preliminary results demonstrate that standoff LIBS has the potential to discriminate hazardous materials in more complex backgrounds.
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Using Double Mass Selection and Reaction Cell Gases to Resolve Isobaric Spectral Overlaps in ICP-MSWhen using a triple-quadrupole ICP-MS system, the increased abundance sensitivity of MS/MS mode makes it possible to measure trace elements using isotopes that would otherwise be affected by peak tailing from an adjacent major element. This approach is illustrated using the example of ultratrace 237Np analysis in the presence of 10 ppm U.
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Synthesis and Structural Elucidation of Impurities in Ramipril TabletsIn this article, the authors take a look at the identification, synthesis, and characterization of impurities in Ramipril tablets.
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Synthesis and Structural Elucidation of Impurities in Ramipril TabletsIn this article, the authors take a look at the identification, synthesis, and characterization of impurities in Ramipril tablets.
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Synthesis and Structural Elucidation of Impurities in Ramipril TabletsIn this article, the authors take a look at the identification, synthesis, and characterization of impurities in Ramipril tablets.
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Liquid Chromatography Coupled with Tandem Mass Spectrometry for Clinical ApplicationsThe authors discuss the emergence of liquid chromatography coupled with tandem mass spectrometry as a complementary method to traditional methodology used for clinical applications.
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A New Perspective on the Challenges of Mass SpectrometryThe authors discuss the challenges presented by the many new applications of mass spectrometry.
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Bioanalysis Using Dried Blood Spots: The Biggest Advancement in Bioanalysis Since LC–MS-MS?The collection of blood-derived samples from preclinical and clinical trial studies onto paper-based, Guthrie-type cards is gaining momentum within the pharmaceutical industry. This approach holds the potential to minimize animal usage, improve data quality, and reduce shipping costs. However, the small sample volumes and extra matrix effects from the cards result in method development and sensitivity challenges for bioanalysts. Here, we present a discussion on the analytical challenges that both liquid chromatography and mass spectrometry face as well as present some potential solutions to these issues.
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Raman Analysis of Embedded ContaminantsRaman confocal spectroscopy is increasingly being applied for the analysis of embedded contaminants within materials. A non-contact, non-destructive analysis method, Raman spectroscopy requires very little sample preparation, has greater spatial resolution compared to FT-IR microscopy and the confocal analysis method allows visualization of materials within a clear sample matrix. This paper will investigate the analysis of an embedded contaminant within a polymer matrix on a glass substrate.
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Plant Metabolomic Workflows Using Reversed-Phase LC and HILIC with ESI-TOF-MSIn plant metabolomics, molecular fingerprints and additional molecular descriptors can be identified using recent developments in polarity-extended separations with serial coupling of reversed-phase LC and HILIC combined with ESI-TOF-MS.
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Current Status of Standoff LIBS Security Applications at the United States Army Research LaboratoryThe United States Army Research Laboratory (ARL) has been applying standoff laser-induced breakdown spectroscopy (LIBS) to hazardous material detection and determination. We describe several standoff systems that have been developed by ARL and provide a brief overview of standoff LIBS progress at ARL. We also present some current standoff LIBS results from explosive residues on organic substrates and biomaterials from different growth media. These new preliminary results demonstrate that standoff LIBS has the potential to discriminate hazardous materials in more complex backgrounds.
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Tracking Microplastics in the Environment via FT-IR MicroscopyMicroplastics from clothing, abrasive action on plastics, or engineered microbeads as found in some exfoliating cosmetics are showing up in many environmental systems. FT-IR microscopy is a useful tool in the analysis of microplastics, providing visual information, particle counts, and particle identification.
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Posttranslational Modification Characterization via Electron Capture Dissociation Using a Linear Ion Trap Time-of-Flight Mass SpectrometerThe authors introduce a compact ECD device coupled to a linear ion trap time-of-flight instrument, and use it to analyze protein phosphorylation in both offline and online modes.
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GC-ICP-MS for Process and Quality Control in Semiconductor ManufacturingManufacturing advanced electronic devices requires the production of high-quality semiconductors and integrated circuit chips. In this article, the authors explain how GC, when coupled with ICP-MS, enables the detection of elements that are essential in semiconductor production.
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Advances in Infrared Microspectroscopy and Mapping Molecular Chemical Composition at Submicrometer Spatial ResolutionInfrared microspectroscopy has led to important advances in a wide range of fields, as biologists, chemists, geologists, materials scientists, microscopists, and spectroscopists around the world have awakened to the values of nanotechnology. The small world is getting larger.
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Multitargeting PesticidesThe usefulness of liquid chromatography–mass spectrometry–mass spectrometry (LC–MS-MS) methods for the unambiguous identification and quantification of pesticides in complex matrix samples is well known. Triple-quadrupole systems have proven to be useful for this task because of their high specificity in MS-MS mode and their low detection limits. However, working in MS-MS mode makes any MS system blind to other compounds of interest.
