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Dosing Vehicle Removal in Discovery Phase Pharmacokinetic Studies Using High-Field Asymmetric Waveform Ion Mobility SpectrometryThis article describes the ability to increase the sensitivity for a target compound in the presence of high-level background impurities by removing the dosing vehicle using a high-field asymmetric waveform ion mobility spectrometry gas-phase separation before mass spectrometry analysis.
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GC-ICP-MS for Process and Quality Control in Semiconductor ManufacturingManufacturing advanced electronic devices requires the production of high-quality semiconductors and integrated circuit chips. In this article, the authors explain how GC, when coupled with ICP-MS, enables the detection of elements that are essential in semiconductor production.
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Single-Particle Spectroscopy on Conducting Polymer-Fullerene Composite Materials for Application in Organic Photovoltaic DevicesThe study of the photophysical and optoelectronic properties of a functioning conducting polymer device is complicated and is hampered by the complex nanostructure and morphology of the conducting polymer materials in these devices. Here we discuss an approach to investigate this issue in terms of bulk-heterojunction organic photovoltaic devices.
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Synthesis and Structural Elucidation of Impurities in Ramipril TabletsIn this article, the authors take a look at the identification, synthesis, and characterization of impurities in Ramipril tablets.
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Ion Chromatography–Mass Spectrometry for Profiling Low Molecular Mass Organic Acids in Beverages and BiomassThis article describes an ion chromatography–mass spectrometry (IC-MS) method for profiling low molecular mass organic acids in consumer beverages and biomass used in biofuel production.
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IC–ICP–MS Speciation Analysis of As in Apple JuiceIn this study, apple juice samples are analyzed by IC–ICP–MS to determine the concentration of six arsenic species: the two inorganic, and highly toxic, species (As (V) and As [III]) and four organic species (arsenobetaine [AsB], arsenocholine [AsC], monomethylarsonic acid [MMA], and dimethylarsinic acid [DMA]).
Latest:
Using Comprehensive GC×GC–TOF-MS for Enhanced Detection and Separation in Antidoping Control ScreeningThe misuse of androgenic anabolic steroids in sports was banned in 1976 by the International Olympic Committee and global sports community. The illegal use of anabolic steroids has reached disturbing levels worldwide. This worldwide problem is fueled partially by an ever-increasing demand for better athletic performance. The World Anti-Doping Agency has formulated strict guidelines for minimum allowable concentrations of exogenous anabolic steroids and their metabolites. The standard test methods for doping control are analyzed in urine samples with trimethyl-silyl derivatization. Urine is a complex and difficult biological matrix. This research shows the advantages of using comprehensive two-dimensional gas chromatography–time-of-flight-mass spectrometry (GCÃ-GC–TOF-MS) and illustrates the capability of GCÃ-GC-TOF-MS to be an effective instrumental option for antidoping control screening.
Latest:
Comprehensive Screening, Confirmation, and Quantification of Organic Pesticides in Foods by GC–MS and LC–MSThis article provides an overview of the instrument platforms, tools, and workflow for analyzing pesticides.
