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Rapid Online Reduction and Characterization of Protein Modifications Using Fully Automated Two-Dimensional High Performance Liquid Chromatography–Mass SpectrometryA fully automated process for online peak fractionation and reduction of therapeutic antibodies with subsequent QTOF-MS characterization is presented. The technique is based on state-of-the-art 2D-HPLC technology coupled with additional HPLC modules via a dedicated software macro.
Latest:
Rapid Online Reduction and Characterization of Protein Modifications Using Fully Automated Two-Dimensional High Performance Liquid Chromatography–Mass SpectrometryA fully automated process for online peak fractionation and reduction of therapeutic antibodies with subsequent QTOF-MS characterization is presented. The technique is based on state-of-the-art 2D-HPLC technology coupled with additional HPLC modules via a dedicated software macro.
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The 2018 Emerging Leader in Atomic Spectroscopy AwardJohn M. Cottle, the winner of Spectroscopy’s 2018 Emerging Leader in Atomic Spectroscopy Award, is a leader in the development of novel laser-ablation inductively coupled plasma–mass spectrometry measurements and their application to tectonic questions in convergent orogens. His three breakthrough measurement methods using LA-ICP-MS for geochemical data collection are breaking new ground in Earth science.
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Recent Developments in X-ray AnalysisIn our annual presentation of trends in X-ray analysis, experts in the field provide updates on recent developments in X-ray analysis, focusing on the technique and relevant applications.
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Testing Electronic Device Components for RoHS/WEEE Compliance Using Microwave Digestion and ICP-OESThe combination of microwave sample preparation and ICP-OES is examined to meet the challenges of measuring a suite of heavy metals in a wide range of electronic components for RoHS/WEEE compliance.
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Portable Raman Spectrometers: How Small Can They Get?There is a growing desire among spectroscopists for having instruments small enough to be taken to the sample, as opposed to bringing the sample to the instrument. The result is that Raman spectrometers are becoming more miniaturized. Because these instruments come at a lower cost and offer distinct advantages over traditional spectrometers, the expectation is that a rapid expansion of when these instruments are applied will come forthwith. We offer a preview of how future miniaturized Raman spectrometers might look.
Latest:
Portable Raman Spectrometers: How Small Can They Get?There is a growing desire among spectroscopists for having instruments small enough to be taken to the sample, as opposed to bringing the sample to the instrument. The result is that Raman spectrometers are becoming more miniaturized. Because these instruments come at a lower cost and offer distinct advantages over traditional spectrometers, the expectation is that a rapid expansion of when these instruments are applied will come forthwith. We offer a preview of how future miniaturized Raman spectrometers might look.
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Morphologically Directed Raman Spectroscopic Analysis of Forensic SamplesCan morphologically directed Raman spectroscopy obtain more discriminatory information from forensic samples than current tools?
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Morphologically Directed Raman Spectroscopic Analysis of Forensic SamplesCan morphologically directed Raman spectroscopy obtain more discriminatory information from forensic samples than current tools?
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Morphologically Directed Raman Spectroscopic Analysis of Forensic SamplesCan morphologically directed Raman spectroscopy obtain more discriminatory information from forensic samples than current tools?
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Morphologically Directed Raman Spectroscopic Analysis of Forensic SamplesCan morphologically directed Raman spectroscopy obtain more discriminatory information from forensic samples than current tools?
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The miniDOAS: Low Cost, High Performance Contactless Ammonia MeasurementsKnowledge of atmospheric ammonia concentrations is important, but ammonia is difficult to measure. We report here on the development of a low-cost ammonia measuring differential optical absorption spectroscopy (DOAS) instrument, based on a small sized and low priced spectrograph.
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Imaging Enhanced II: Today’s Raman Microscopy ApplicationsTuesday, June 28, 2022 at 1pm EDT | 6pm BST | 7pm CEST Confocal Raman imaging microscopy is a powerful, versatile, and increasingly common analytical technique capable of quickly identifying the molecules in a sample and visualizing their physical distribution in three dimensions. The conference will give a comprehensive overview of current technologies and their latest applications.
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Analysis of Nitriles By Diamond ATRThis application note compares the sensitivity of a single-reflection to multiple-reflection ATR for the nitrile functional group infrared transition.
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Improved Sensitivity with the New Apollo XRF ML-50 Detector on the Orbis Micro-XRF AnalyzerThe measurement of trace elements is important across a wide variety of materials characterization problems. When measuring small glass fragments collected from crime and accident scenes, forensics experts analyze trace strontium (Sr) and zirconium (Zr) typically unintentionally incorporated into the glass during manufacturing as one point of identification or comparison.
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Peptide Mapping of Monoclonal Antibodies and Antibody–Drug Conjugates Using Micro-Pillar Array Columns Combined with Mass SpectrometryThe structural complexity of monoclonal antibodies (mAbs) challenges the capabilities of even the most advanced chromatography and mass spectrometry techniques. This study examines the use of micro-pillar array columns in combination with mass spectrometry for peptide mapping of both mAbs and antibody–drug conjugates (ADCs).
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Liquid Chromatography Tandem Mass Spectrometry Method for Novel Psychoactive Substances: Kratom and Synthetic Cathinones in UrineA novel “dilute-and-shoot” LC–MS/MS method is described for the analysis of “bath salts” sold as “legal” highs, including mitragynine and nine synthetic cathinones, in urine.
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Liquid Chromatography Tandem Mass Spectrometry Method for Novel Psychoactive Substances: Kratom and Synthetic Cathinones in UrineA novel “dilute-and-shoot” LC–MS/MS method is described for the analysis of “bath salts” sold as “legal” highs, including mitragynine and nine synthetic cathinones, in urine.
Latest:
Liquid Chromatography Tandem Mass Spectrometry Method for Novel Psychoactive Substances: Kratom and Synthetic Cathinones in UrineA novel “dilute-and-shoot” LC–MS/MS method is described for the analysis of “bath salts” sold as “legal” highs, including mitragynine and nine synthetic cathinones, in urine.
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Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Rapid Online Reduction and Characterization of Protein Modifications Using Fully Automated Two-Dimensional High Performance Liquid Chromatography–Mass SpectrometryA fully automated process for online peak fractionation and reduction of therapeutic antibodies with subsequent QTOF-MS characterization is presented. The technique is based on state-of-the-art 2D-HPLC technology coupled with additional HPLC modules via a dedicated software macro.
Latest:
Rapid Online Reduction and Characterization of Protein Modifications Using Fully Automated Two-Dimensional High Performance Liquid Chromatography–Mass SpectrometryA fully automated process for online peak fractionation and reduction of therapeutic antibodies with subsequent QTOF-MS characterization is presented. The technique is based on state-of-the-art 2D-HPLC technology coupled with additional HPLC modules via a dedicated software macro.
