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Quantitative Detection of Phenobarbital in an Injectable Solution Based on Surface-Enhanced Raman SpectroscopyThis SERS method is rapid, accurate, nondestructive, and easy
Latest:
Quantitative Detection of Phenobarbital in an Injectable Solution Based on Surface-Enhanced Raman SpectroscopyThis SERS method is rapid, accurate, nondestructive, and easy
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Epitope Mapping of an Interleukin Receptor for Three Therapeutic Antibodies by Hydrogen-Deuterium Exchange Mass SpectrometryAmong all the analytical techniques available for epitope mapping studies, hydrogen–deuterium exchange mass spectrometry (HDX-MS) is usually the fastest and easiest to carry out. We present here the epitope mapping of three distinct monoclonal antibody (mAb) candidates targeting the same antigen, an interleukin receptor. The goal is to establish the binding mode of these mAbs, and explain possible differences observed for in vitro binding and in vivo function.
Latest:
Epitope Mapping of an Interleukin Receptor for Three Therapeutic Antibodies by Hydrogen-Deuterium Exchange Mass SpectrometryAmong all the analytical techniques available for epitope mapping studies, hydrogen–deuterium exchange mass spectrometry (HDX-MS) is usually the fastest and easiest to carry out. We present here the epitope mapping of three distinct monoclonal antibody (mAb) candidates targeting the same antigen, an interleukin receptor. The goal is to establish the binding mode of these mAbs, and explain possible differences observed for in vitro binding and in vivo function.
Latest:
Epitope Mapping of an Interleukin Receptor for Three Therapeutic Antibodies by Hydrogen-Deuterium Exchange Mass SpectrometryAmong all the analytical techniques available for epitope mapping studies, hydrogen–deuterium exchange mass spectrometry (HDX-MS) is usually the fastest and easiest to carry out. We present here the epitope mapping of three distinct monoclonal antibody (mAb) candidates targeting the same antigen, an interleukin receptor. The goal is to establish the binding mode of these mAbs, and explain possible differences observed for in vitro binding and in vivo function.
Latest:
Enhancing the Sensitivity of Atmospheric Pressure Ionization Mass Spectrometry Using Flow Modulated Gas ChromatographyThe past decade has witnessed resurgent interest in coupling GC to atmospheric-pressure chemical ionization (APCI), which is suitable for the high column flows required for using flow modulation. This study assesses the use of GP-APCI with flow modulation for sensitive detection of selected trace organics.
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Recent Advances in Hyphenated Chromatography and Mass Spectrometry Techniques and Their Impact on Late-Stage Pharmaceutical DevelopmentIn late-stage pharmaceutical development a new generation of high-resolution mass spectrometers and ion mobility mass spectrometers operate as orthogonal separation techniques and have greatly increased the ability to resolve impurities and increase the level of analytical information gained from a single analysis.
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Recent Advances in Hyphenated Chromatography and Mass Spectrometry Techniques and Their Impact on Late-Stage Pharmaceutical DevelopmentIn late-stage pharmaceutical development a new generation of high-resolution mass spectrometers and ion mobility mass spectrometers operate as orthogonal separation techniques and have greatly increased the ability to resolve impurities and increase the level of analytical information gained from a single analysis.
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Effective Abatement of High Lead Level Contamination in a Forensic Firing Range via Inductively Coupled Plasma–Mass SpectrometryTest firing a firearm is frequently used for forensic firearms and bullet identification. Airborne lead-containing particles are emitted when a firearm is tested, leading to lead building up on surfaces, exposing employees to potential lead-related health risks. Prior to cleaning, lead surface concentrations in the firing range at the National Forensic Laboratory Services in Ottawa were found to be higher than the Environmental Abatement Council of Ontario (EACO) post-abatement limit, with the highest level 56 times the limit. Inductively coupled plasma–mass spectrometry (ICP-MS), along with internal standardization, revealed that wiping surfaces with either a commercial decontamination product containing ethylene glycol butyl ether (EGBE) or alcohol cleaning pads satisfied the EACO standard by removing over 90% of lead from test surfaces whereas an external cleaning company only removed 36% of lead from the same surfaces. Fortunately, lead cross-contamination was minimal outside the firearms section and well below the residential EACO limit.
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Characterization of Glitter Cosmetic Particles Using FT-IR SpectroscopyGlitter particles from cosmetics may transfer during personal assaults, and thus glitter may be useful as a forensic tool. In this study, glitter samples were analyzed using ATR–FT-IR in an attempt to develop a characterization scheme to aid in the identification of these particles.
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GC×GC–MS for Forensic AnalysisForensic scientists often encounter highly complex analytical problems related to crime scenes that would benefit from the capabilities of GC×GC–MS. However, this technique has not been fully explored to help benefit forensic laboratories.
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A Spectroscopic Revolution in the Agricultural WorldIn celebration of Spectroscopy’s 35th Anniversary, leading experts discuss important issues and challenges in analytical spectroscopy.
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Fast Quality Evaluation of Bulk Polymers and Products Using FT-NIR SpectroscopyFT-NIR spectroscopy for the quantitative determination of key physical parameters in bulk polymers and products, including density and melt index (MI). These measurements can often be made with little or no sample preparation.
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Analyze Li-ion Battery Anodes with inVia™The inVia microscope is ideal for locating, discriminating, and quantifying various forms of carbon present in anodes, even those with subtle variations in structure.
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A Comparison of Portable Infrared Spectrometers, Portable Raman Spectrometers, and Color-Based Field Tests for the On-Scene Analysis of CocaineOn-scene analysis of cocaine is an essential tool for law enforcement. This study defines how portable infrared and Raman spectrometers are capable of providing accurate and reliable identification of cocaine and other drugs when and where needed most.
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A Comparison of Portable Infrared Spectrometers, Portable Raman Spectrometers, and Color-Based Field Tests for the On-Scene Analysis of CocaineOn-scene analysis of cocaine is an essential tool for law enforcement. This study defines how portable infrared and Raman spectrometers are capable of providing accurate and reliable identification of cocaine and other drugs when and where needed most.
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A Comparison of Portable Infrared Spectrometers, Portable Raman Spectrometers, and Color-Based Field Tests for the On-Scene Analysis of CocaineOn-scene analysis of cocaine is an essential tool for law enforcement. This study defines how portable infrared and Raman spectrometers are capable of providing accurate and reliable identification of cocaine and other drugs when and where needed most.
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Rapid Classification of Beef Aroma Quality Using SIFT-MSApplication of multivariate statistical analysis to a combined data set demonstrated that SIFT-MS discriminates premium quality beef from eight sensory defects, and, therefore, could be applied as an instrumental grading tool, obviating sensory panel grading.
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Rapid Classification of Beef Aroma Quality Using SIFT-MSApplication of multivariate statistical analysis to a combined data set demonstrated that SIFT-MS discriminates premium quality beef from eight sensory defects, and, therefore, could be applied as an instrumental grading tool, obviating sensory panel grading.
Latest:
Rapid Classification of Beef Aroma Quality Using SIFT-MSApplication of multivariate statistical analysis to a combined data set demonstrated that SIFT-MS discriminates premium quality beef from eight sensory defects, and, therefore, could be applied as an instrumental grading tool, obviating sensory panel grading.
Latest:
Immunoaffinity Solid-Phase Extraction with HPLC-FLD Detection for the Determination of Aflatoxins B2, B1, G2, and G1 in Ground HazelnutUsing highly specific immunoaffinity solid-phase extraction to selectively extract and enrich aflatoxins prior to HPLC-FLD analysis, without derivatization, low LOQ values-far below the European regulations-can be achieved even in highly complex and fatty matrices.
Latest:
Immunoaffinity Solid-Phase Extraction with HPLC-FLD Detection for the Determination of Aflatoxins B2, B1, G2, and G1 in Ground HazelnutUsing highly specific immunoaffinity solid-phase extraction to selectively extract and enrich aflatoxins prior to HPLC-FLD analysis, without derivatization, low LOQ values-far below the European regulations-can be achieved even in highly complex and fatty matrices.
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Comprehensive Identification of Migrating Compounds from Plastic Food Packaging Materials Using High-Resolution Mass SpectrometryThis study assesses whether two commonly used plastic packaging materials are safe for use. Their potential migrants are analyzed using data-independent acquisition and liquid chromatography coupled with high-resolution, accurate-mass mass spectrometry.
Latest:
Comprehensive Identification of Migrating Compounds from Plastic Food Packaging Materials Using High-Resolution Mass SpectrometryThis study assesses whether two commonly used plastic packaging materials are safe for use. Their potential migrants are analyzed using data-independent acquisition and liquid chromatography coupled with high-resolution, accurate-mass mass spectrometry.
Latest:
Comprehensive Identification of Migrating Compounds from Plastic Food Packaging Materials Using High-Resolution Mass SpectrometryThis study assesses whether two commonly used plastic packaging materials are safe for use. Their potential migrants are analyzed using data-independent acquisition and liquid chromatography coupled with high-resolution, accurate-mass mass spectrometry.
Latest:
Immunoaffinity Solid-Phase Extraction with HPLC-FLD Detection for the Determination of Aflatoxins B2, B1, G2, and G1 in Ground HazelnutUsing highly specific immunoaffinity solid-phase extraction to selectively extract and enrich aflatoxins prior to HPLC-FLD analysis, without derivatization, low LOQ values-far below the European regulations-can be achieved even in highly complex and fatty matrices.
Latest:
Rapid Determination of the Peroxide Value of Edible Oil by Handheld NIR Spectroscopy in Combination with Wavelength Variables Selection and PLS CalibrationA PLS model was built with optimized wavelength variables generated by a competitive adaptive reweighted sampling (CARS) algorithm, enabling the use of handheld NIR spectroscopy to rapidly detect peroxide values in oil.
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Handheld Raman, Mid-Infrared and Near Infrared Spectrometers: State-of-the-Art Instrumentation and Useful ApplicationsHandheld Raman, mid-infrared and near infrared spectrometers have launched vibrational spectroscopy into a new era of in-the-field and on-site analysis, as the application examples discussed here demonstrate. We assess the technological developments that have led to this progress.
