Authors
Latest:
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Rapid Online Reduction and Characterization of Protein Modifications Using Fully Automated Two-Dimensional High Performance Liquid Chromatography–Mass SpectrometryA fully automated process for online peak fractionation and reduction of therapeutic antibodies with subsequent QTOF-MS characterization is presented. The technique is based on state-of-the-art 2D-HPLC technology coupled with additional HPLC modules via a dedicated software macro.
Latest:
Rapid Online Reduction and Characterization of Protein Modifications Using Fully Automated Two-Dimensional High Performance Liquid Chromatography–Mass SpectrometryA fully automated process for online peak fractionation and reduction of therapeutic antibodies with subsequent QTOF-MS characterization is presented. The technique is based on state-of-the-art 2D-HPLC technology coupled with additional HPLC modules via a dedicated software macro.
Latest:
Rapid Online Reduction and Characterization of Protein Modifications Using Fully Automated Two-Dimensional High Performance Liquid Chromatography–Mass SpectrometryA fully automated process for online peak fractionation and reduction of therapeutic antibodies with subsequent QTOF-MS characterization is presented. The technique is based on state-of-the-art 2D-HPLC technology coupled with additional HPLC modules via a dedicated software macro.
Latest:
Rapid Online Reduction and Characterization of Protein Modifications Using Fully Automated Two-Dimensional High Performance Liquid Chromatography–Mass SpectrometryA fully automated process for online peak fractionation and reduction of therapeutic antibodies with subsequent QTOF-MS characterization is presented. The technique is based on state-of-the-art 2D-HPLC technology coupled with additional HPLC modules via a dedicated software macro.
Latest:
Rapid Online Reduction and Characterization of Protein Modifications Using Fully Automated Two-Dimensional High Performance Liquid Chromatography–Mass SpectrometryA fully automated process for online peak fractionation and reduction of therapeutic antibodies with subsequent QTOF-MS characterization is presented. The technique is based on state-of-the-art 2D-HPLC technology coupled with additional HPLC modules via a dedicated software macro.
Latest:
Tuning Process for ICP-MSLatest:
Tunable Diode Lasers for Trace Gas Detection: Methods, Developments, and Future OutlookTunable diode laser absorption spectroscopy is hitting the mainstream. Here, we look at the history of the technique, the current state of the technology, and future challenges.
Latest:
X-ray Photoelectron Spectroscopy Analysis of the Enhanced Corrosion Resistance of Thermally Oxidized Stainless SteelAlthough recent steel coating methods have demonstrated improvements in corrosion resistance, they can prove expensive and complicated. In this study, XPS analysis was used to evaluate the corrosion resistance of steel treated with an alternative technique.
Latest:
The Role of Mass Spectrometry in Biopharmaceutical Drug Discovery and DevelopmentAs biopharmaceuticals continue to increase in sophistication, how can their discovery and development be managed to reduce uncertainties and expedite the process?
Latest:
From Heavy Metals Testing to the Measurement of Elemental Impurities in Pharmaceuticals: Over 100 Years in Making the ChangeA look at the implementation of the new United States Pharmacopeia (USP) chapters and the International Conference for Harmonization (ICH) guidelines for elemental impurities from an historical perspective, providing insight into the changes and considering the challenges and opportunities that lie ahead as the industry embraces the new methodology.
Latest:
Recent Advances and Trends in Inductively Coupled Plasma–Mass Spectrometry and ApplicationsThere have been exciting recent advances in ICP-MS instrumentation, such as the development of magnetic sector ICP-MS, multicollector ICP-MS, time-of-flight ICP-MS, and triple-quadrupole ICP-MS, as well as developments in the coupling of laser ablation (LA) and laser-induced breakdown spectroscopy (LIBS) to ICP-MS. This article surveys these developments and looks to the future.
Latest:
The Use of MALDI Imaging Mass Spectrometry for Interdisciplinary Research: From Metabolomics to PesticidesMatrix-assisted laser desorption–ionization (MALDI) imaging mass spectrometry allows direct, in situ, label-free measurement of proteins, peptides, lipids, small-molecule drugs and their metabolites, and other chemicals in tissues. In a range of applications, the unique information generated by MALDI imaging can make a significant contribution to understanding factors such as molecular and metabolic mechanisms and the transport and localization of compounds or metabolites with human, animal, or plant species.
Latest:
The Use of MALDI Imaging Mass Spectrometry for Interdisciplinary Research: From Metabolomics to PesticidesMatrix-assisted laser desorption–ionization (MALDI) imaging mass spectrometry allows direct, in situ, label-free measurement of proteins, peptides, lipids, small-molecule drugs and their metabolites, and other chemicals in tissues. In a range of applications, the unique information generated by MALDI imaging can make a significant contribution to understanding factors such as molecular and metabolic mechanisms and the transport and localization of compounds or metabolites with human, animal, or plant species.
Latest:
Resolving Volume-Restricted Metabolomics Using Sheathless Capillary Electrophoresis–Mass SpectrometryRecent advances have significantly improved the performance of capillary electrophoresis–mass spectrometry (CE–MS) for the profiling of polar and charged metabolites in volume-restricted or mass-limited biological samples. Here, those advances are discussed, and attention is also devoted to various technical aspects that still need to be addressed.
Latest:
Liquid Chromatography–Atmospheric Pressure Photoionization-Mass Spectrometry Analysis of the Nonvolatile Precursors of Rancid Smell in MayonnaiseFor lipid-containing food products like mayonnaise, determining nonvolatile lipid oxidation products, the precursor compounds for rancidity, makes it possible to predict product shelf life at an earlier stage in product development. A method based on normal-phase liquid chromatography with atmospheric pressure photoionization-mass spectrometry (LC–APPI-MS) was developed for this purpose.
