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Rapid Enantiodifferentation of Chiral Organophosphorus Compounds by 31P NMR Spectroscopy in the Presence of α-Cyclodextrin as the Chiral Solvating AgentThis method, for the evaluation of the enantiomeric purity of particular phosphonate derivatives, offers advantages in terms of cost, simplicity, and measurement speed.
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Overcoming Struggles in Implementing Handheld Raman Spectroscopy Across the Manufacturing LineIndustry leaders answer this question: In what area will spectroscopy see the biggest growth in the next five years?
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Peptide Mapping of Monoclonal Antibodies and Antibody–Drug Conjugates Using Micro-Pillar Array Columns Combined with Mass SpectrometryThe structural complexity of monoclonal antibodies (mAbs) challenges the capabilities of even the most advanced chromatography and mass spectrometry techniques. This study examines the use of micro-pillar array columns in combination with mass spectrometry for peptide mapping of both mAbs and antibody–drug conjugates (ADCs).
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Peptide Mapping of Monoclonal Antibodies and Antibody–Drug Conjugates Using Micro-Pillar Array Columns Combined with Mass SpectrometryThe structural complexity of monoclonal antibodies (mAbs) challenges the capabilities of even the most advanced chromatography and mass spectrometry techniques. This study examines the use of micro-pillar array columns in combination with mass spectrometry for peptide mapping of both mAbs and antibody–drug conjugates (ADCs).
Latest:
Peptide Mapping of Monoclonal Antibodies and Antibody–Drug Conjugates Using Micro-Pillar Array Columns Combined with Mass SpectrometryThe structural complexity of monoclonal antibodies (mAbs) challenges the capabilities of even the most advanced chromatography and mass spectrometry techniques. This study examines the use of micro-pillar array columns in combination with mass spectrometry for peptide mapping of both mAbs and antibody–drug conjugates (ADCs).
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A New Path to High-Resolution HPLC–TOF-MS — Survey, Targeted, and Trace Analysis Applications of TOF-MS in the Analysis of Complex Biochemical MatricesThe impact of speed of analysis and selectivity to the depth of coverage and accuracy of the analyses are discussed.
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The Importance of Method Development for Trace-Element Analysis by Inductively Coupled Plasma–Optical Emission SpectroscopySelecting the correct wavelengths or isotopes and optimizing flame, furnace, or plasma conditions can seem a daunting task for a novice user, with a multitude of opportunities to introduce errors and generate poor quality data. While most elemental analysis instruments have intuitive operating software, they lack the intelligence to guide the operator through the early stages of method development and overcome associated problems along the way. This study describes an automated, intelligent approach to method development for trace element analysis using optical emission spectroscopy, and exemplifies this capability with a suite of real-world sample matrices.
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Mass Spectrometry Techniques to Unravel the Heterogeneity of GlycoproteinsSince glycans are responsible for bioactivity, solubility, immunogenicity, and clearance rate from circulation, it is vital to have a detailed map of glycans in therapeutic glycoproteins. Detailed glycoprotein structural analysis must be able to identify the peptide sequence where the glycans are attached as well as the structure of the glycan portion, including oligosaccharide sequence and glycosyl linkages. This article details methods for mass spectrometry experiments on both released glycans (“glycomics”), as well as on intact glycopeptides (“glycoproteomics”) using electron transfer dissociation, high-energy collision dissociation, and collisioninduced dissociation fragmentation pathways, which are needed to fully elucidate the structure of glycoproteins.
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Using XRF as an Alternative Technique to Plasma Spectrochemistry for the New USP and ICH Directives on Elemental Impurities in Pharmaceutical MaterialsAn evaluation of the ability of XRF spectrometry to perform elemental impurity analysis of 12 elements in various pharmaceutical materials
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Using XRF as an Alternative Technique to Plasma Spectrochemistry for the New USP and ICH Directives on Elemental Impurities in Pharmaceutical MaterialsAn evaluation of the ability of XRF spectrometry to perform elemental impurity analysis of 12 elements in various pharmaceutical materials
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Inorganic Products: Mining Ores, Catalysts, Superalloys, and CeramicsThe Milestone UltraWAVE can digest up to 22 different sample types simultaneously. The high temperature and pressure capability enables a complete digestion of nearly all inorganic sample types that need to be analyzed for trace metals.
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Detection and Characterization of Extractables in Food Packaging Materials by GC–MSIn this study, general extract screening of food storage materials was done with nontargeted analytical methods to understand what analytes could potentially leach into food or beverages. GC and mass spectral deconvolution effectively separated analytes within the complex mixture and TOF-MS provided full mass range spectral data for identification. This workflow can be used for confident characterization of components present as extractables from food packaging materials.
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Ion Mobility Spectrometers as Chromatographic DetectorsInterest in connecting ion mobility spectrometry (IMS) to GC and especially to LC is now growing. One favorable property of IMS is that it can work with ambient pressure and can be easily connected to a gas or liquid chromatograph. Analytical applications of GC–MS and LC–MS are very different and encompass investigations into food, medical science, environment, drugs of abuse, chemical warfare agents, and explosives.
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Ion Mobility Spectrometers as Chromatographic DetectorsInterest in connecting ion mobility spectrometry (IMS) to GC and especially to LC is now growing. One favorable property of IMS is that it can work with ambient pressure and can be easily connected to a gas or liquid chromatograph. Analytical applications of GC–MS and LC–MS are very different and encompass investigations into food, medical science, environment, drugs of abuse, chemical warfare agents, and explosives.
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Simultaneous, Automated Extraction of 96 Urine Samples for Drugs of Abuse Analysis by LC–MS/MS Using the Microlab® NIMBUS® WorkstationUtilizing Hamilton’s CO-RE® disposable tips with DPX technology provides a fast, accurate, and simple extraction method for analyzing drugs of abuse in urine. The Microlab NIMBUS equipped with a CO-RE 96-channel Multi-Probe Head (MPH) allows for high-throughput, automated sample processing.
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Simultaneous, Automated Extraction of 96 Urine Samples for Drugs of Abuse Analysis by LC–MS/MS Using the Microlab® NIMBUS® WorkstationUtilizing Hamilton’s CO-RE® disposable tips with DPX technology provides a fast, accurate, and simple extraction method for analyzing drugs of abuse in urine. The Microlab NIMBUS equipped with a CO-RE 96-channel Multi-Probe Head (MPH) allows for high-throughput, automated sample processing.
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Validation of Horizon Technology Disk Extraction Technology for US EPA Wastewater Method 625.1This application note will present the data collected as part of the demonstration of disk solid phase extraction validation for US EPA method 625.1.
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Practical Autodilution for ICP-MS and ICP-OESGain insights into improving efficiency and accuracy in elemental analysis through automated dilution technology. Learn about the key capabilities of the Agilent ADS 2 system and its seamless integration with ICP-MS and ICP-OES workflows.
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Performance of the Savillex VC Ultra (August 2022)Effectiveness of VC Ultra for automated cleaning of microwave digestion vessels following the digestion of a sample containing relatively high amounts of trace metals
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Analysis of Organometallic Compounds and Metallic Particles in Specialty Gases by Direct Injection Using Gas Exchange Device (GED) Coupled to Inductively Coupled Plasma–Mass Spectrometry (ICP-MS)In this article, we introduce the concept of a gas exchange device (GED) and how it can be used to monitor organometallic compounds and metallic particles in specialty gases.
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EDX and LIBS Studies on Gallstones Using Partial Least Squares Discriminant Analysis (PLS-DA)Understanding gallstone formation requires examining their elemental composition. Here, EDS and LIBS were used with PLS-DA to quantify elements found in human gallstones.
