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The Use of Portable Near-Infrared Spectroscopy for Authenticating Cardiovascular MedicinesPortable NIR spectroscopy is demonstrated as a rapid and mobile analysis method for authenticating cardiovascular medicines in critical situations, and to indicate whether formulations are counterfeit or substandard.
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Tri-Range Applications of the Spectrum 3 Infrared SpectrometerTri-Range Applications of the Spectrum 3 Infrared Spectrometer
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Quantitation and Nontargeted Identification of Pesticides in Spinach Extract with GC×GC–TOF-MSIn this study of pesticides in spinach extract, the use of GC×GC–TOF-MS is demonstrated as a methodology to overcome matrix interferences and quickly quantify suspected contaminants. The approach also allows nontargeted analysis using a single sample injection.
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Quantitation and Nontargeted Identification of Pesticides in Spinach Extract with GC×GC–TOF-MSIn this study of pesticides in spinach extract, the use of GC×GC–TOF-MS is demonstrated as a methodology to overcome matrix interferences and quickly quantify suspected contaminants. The approach also allows nontargeted analysis using a single sample injection.
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Looking Below the Surface of Breast Tissue During SurgeryIn this article, we present a method that provides prompt detection of the presence of cancer cells inside the 2-mm margin of tissue surrounding the tumor after excision using spatially offset Raman spectroscopy (SORS). SORS was developed to detect subtle changes in soft tissue spectra in the 100–2000 ?m range and tested on excised breast tissues. The results display a very high specificity and sensitivity (100% and 95%, respectively) of classification between positive and negative tumor margins. SORS is a clinically feasible method, suitable for the real-time, intraoperative assessment of tumor margins at the micrometer level.
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Integration of Automated Sample Preparation and ICP-MS Trace Metals Analysis of Clinical SamplesWebinar Date/Time: Tue, Aug 20, 2024 11:00 AM EDT
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Quantitative Analysis of PFAS in Drinking Water Using Liquid Chromatography Tandem Mass SpectrometryPer- and polyfluoroalkyl substances (PFAS) are found in firefighting foams and consumer products. They are ubiquitous in the environment and are an emerging human health concern. This work compares the 2009 and 2018 revised US Environmental Protection Agency (EPA) LC–MS/MS methods of analysis for PFAS in drinking water.
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Simplifying Mixed-Food Microwave Sample Preparation for ICP-MS AnalysisLow-level analysis of food matrices has placed a demand on manufacturers, testing laboratories, and instrumentation vendors worldwide. Stricter regulations, better analytical instrumentation, and greatly improved sample preparation (preanalytical) techniques have focused efforts to simplify and standardize these analyses. Often overlooked, the preanalytical step determines the quality of the resulting data and requires careful attention to a number of details, including sample size, digestion parameters, and the level of detection needed.
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Microparticle in FocusHigh-resolution measurements of particles are of great interest in many fields of application. With ParticleScout, WITec has developed a tool that makes it possible to find, classify, and identify particles automatically.
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Rapid, Portable Pathogen Detection with Multiplexed SERS-based NanosensorsA new application of surface-enhanced Raman spectroscopy (SERS) is described for quantifying low concentrations of pathogens with high reproducibility. In this novel assay, bacteria are captured and isolated using functionalized metal nanoparticles for rapid optical identification via SERS. Initial tests with a portable SERS system validated the ability to identify the presence of Escherichia coli and methicillin-resistant Staphylococcus aureus bacteria.
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Can Raman Spectroscopy Be a Useful Tool in the Fight Against COVID-19?In celebration of Spectroscopy’s 35th Anniversary, leading experts discuss important issues and challenges in analytical spectroscopy.
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Rapid, Portable Pathogen Detection with Multiplexed SERS-based NanosensorsA new application of surface-enhanced Raman spectroscopy (SERS) is described for quantifying low concentrations of pathogens with high reproducibility. In this novel assay, bacteria are captured and isolated using functionalized metal nanoparticles for rapid optical identification via SERS. Initial tests with a portable SERS system validated the ability to identify the presence of Escherichia coli and methicillin-resistant Staphylococcus aureus bacteria.
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Characterizing Microplastic Fibers Using Raman SpectroscopyIn this study, macro- and microscopic Raman spectroscopy were used to identify different commercial microplastic fibers using measured spectra with database searches. Raman microscopy is demonstrated as a powerful technique for microplastic fiber characterization, especially for samples that contain mixtures of components, including multiple polymers, or additives.
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Rapid, Portable Pathogen Detection with Multiplexed SERS-based NanosensorsA new application of surface-enhanced Raman spectroscopy (SERS) is described for quantifying low concentrations of pathogens with high reproducibility. In this novel assay, bacteria are captured and isolated using functionalized metal nanoparticles for rapid optical identification via SERS. Initial tests with a portable SERS system validated the ability to identify the presence of Escherichia coli and methicillin-resistant Staphylococcus aureus bacteria.
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Use of Handheld X-Ray Fluorescence to Analyze Platinum Group Metals in Catalytic ConvertersThe platinum-group metals platinum, palladium, and rhodium are essential and valuable elements in catalytic converters, and thus must be recycled. Handheld X-ray fluorescence (XRF) can be extremely beneficial for analysis of these metals in finely ground materials extracted from used catalytic converters.
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The Importance of Fourier-Transform Infrared Spectroscopy in the Identification of Carbonate Phases Differentiated in Magnesium ContentIn this study, FT-IR spectroscopy was used for identification of carbonate minerals in limestone with variable contents of magnesium. Associated spectral bands were identified and assigned. Results of studies of Triassic limestone samples taken from the area of the Polish part of the Germanic Basin using FT-IR are presented. The results of research show that substitution of Ca2+ by Mg2+ in the carbonate phase lattices leads to a continuous wavenumber increase in the assigned band locations.
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Narrow-Line width Diode Lasers Facilitate Pharmaceutical InspectionLearn about a novel narrow-linewidth 785 nm laser and how it can be used in low-frequency Raman spectroscopy, especially for inspection of pharmaceutical products.
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Determination of Adsorption of Cationic and Anionic Dyes onto Shungite by Raman SpectroscopyA Raman spectroscopy method was used to assess the binding of dyes to different samples of carbon-bearing shungite rock with the same carbon content, but different mineral composition.
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Determination of Adsorption of Cationic and Anionic Dyes onto Shungite by Raman SpectroscopyA Raman spectroscopy method was used to assess the binding of dyes to different samples of carbon-bearing shungite rock with the same carbon content, but different mineral composition.
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A Convenient Alternative to MALDI and ESIAs was demonstrated by ESI and MALDI, and, more recently, ambient ionization approaches, successful new ionization methods can have an enormous impact on science. Novel ionization processes, such as inlet and vacuum ionization, are some of the latest of these approaches, and provide excellent alternatives to traditional approaches.
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High-Throughput Experimentation: Where Does Mass Spectrometry Fit?In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.
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Laser Thermal Desorption and GC×GC for Harsh Environment and Planetary Mass Spectrometry 16The development of analytical instrumentation for harsh terrestrial environments and outer planet space exploration exponentially increases instrument requirements-for features such as robustness, autonomous operation, and speed-and poses unique system integration challenges. Here, we explore the use of laser thermal desorption coupled to comprehensive two-dimensional gas chromatography (LTD-GC×GC) for use with a compact, high-resolution mass spectrometer for challenging applications.
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High-Throughput Experimentation: Where Does Mass Spectrometry Fit?In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.
Latest:
High-Throughput Experimentation: Where Does Mass Spectrometry Fit?In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.
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A Brief Review of Recent Advances in Isomeric N- and O-GlycomicsGlycan isomer expressions have not been well studied, due to inefficient separation and structural identification techniques. Fortunately, with the development of novel separation techniques and liquid chromatography–mass spectrometry (LC–MS) based glycan isomer identification strategies, new efforts have been made to investigate the glycan isomers in various diseases. Here, we review the recent advances of several isomeric separation techniques for both N- and O-linked glycans.
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A Brief Review of Recent Advances in Isomeric N- and O-GlycomicsGlycan isomer expressions have not been well studied, due to inefficient separation and structural identification techniques. Fortunately, with the development of novel separation techniques and liquid chromatography–mass spectrometry (LC–MS) based glycan isomer identification strategies, new efforts have been made to investigate the glycan isomers in various diseases. Here, we review the recent advances of several isomeric separation techniques for both N- and O-linked glycans.
Latest:
A Brief Review of Recent Advances in Isomeric N- and O-GlycomicsGlycan isomer expressions have not been well studied, due to inefficient separation and structural identification techniques. Fortunately, with the development of novel separation techniques and liquid chromatography–mass spectrometry (LC–MS) based glycan isomer identification strategies, new efforts have been made to investigate the glycan isomers in various diseases. Here, we review the recent advances of several isomeric separation techniques for both N- and O-linked glycans.
