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Microparticle in FocusHigh-resolution measurements of particles are of great interest in many fields of application. With ParticleScout, WITec has developed a tool that makes it possible to find, classify, and identify particles automatically.
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Rapid, Portable Pathogen Detection with Multiplexed SERS-based NanosensorsA new application of surface-enhanced Raman spectroscopy (SERS) is described for quantifying low concentrations of pathogens with high reproducibility. In this novel assay, bacteria are captured and isolated using functionalized metal nanoparticles for rapid optical identification via SERS. Initial tests with a portable SERS system validated the ability to identify the presence of Escherichia coli and methicillin-resistant Staphylococcus aureus bacteria.
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Can Raman Spectroscopy Be a Useful Tool in the Fight Against COVID-19?In celebration of Spectroscopy’s 35th Anniversary, leading experts discuss important issues and challenges in analytical spectroscopy.
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Rapid, Portable Pathogen Detection with Multiplexed SERS-based NanosensorsA new application of surface-enhanced Raman spectroscopy (SERS) is described for quantifying low concentrations of pathogens with high reproducibility. In this novel assay, bacteria are captured and isolated using functionalized metal nanoparticles for rapid optical identification via SERS. Initial tests with a portable SERS system validated the ability to identify the presence of Escherichia coli and methicillin-resistant Staphylococcus aureus bacteria.
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Characterizing Microplastic Fibers Using Raman SpectroscopyIn this study, macro- and microscopic Raman spectroscopy were used to identify different commercial microplastic fibers using measured spectra with database searches. Raman microscopy is demonstrated as a powerful technique for microplastic fiber characterization, especially for samples that contain mixtures of components, including multiple polymers, or additives.
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Rapid, Portable Pathogen Detection with Multiplexed SERS-based NanosensorsA new application of surface-enhanced Raman spectroscopy (SERS) is described for quantifying low concentrations of pathogens with high reproducibility. In this novel assay, bacteria are captured and isolated using functionalized metal nanoparticles for rapid optical identification via SERS. Initial tests with a portable SERS system validated the ability to identify the presence of Escherichia coli and methicillin-resistant Staphylococcus aureus bacteria.
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Use of Handheld X-Ray Fluorescence to Analyze Platinum Group Metals in Catalytic ConvertersThe platinum-group metals platinum, palladium, and rhodium are essential and valuable elements in catalytic converters, and thus must be recycled. Handheld X-ray fluorescence (XRF) can be extremely beneficial for analysis of these metals in finely ground materials extracted from used catalytic converters.
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The Importance of Fourier-Transform Infrared Spectroscopy in the Identification of Carbonate Phases Differentiated in Magnesium ContentIn this study, FT-IR spectroscopy was used for identification of carbonate minerals in limestone with variable contents of magnesium. Associated spectral bands were identified and assigned. Results of studies of Triassic limestone samples taken from the area of the Polish part of the Germanic Basin using FT-IR are presented. The results of research show that substitution of Ca2+ by Mg2+ in the carbonate phase lattices leads to a continuous wavenumber increase in the assigned band locations.
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Narrow-Line width Diode Lasers Facilitate Pharmaceutical InspectionLearn about a novel narrow-linewidth 785 nm laser and how it can be used in low-frequency Raman spectroscopy, especially for inspection of pharmaceutical products.
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Determination of Adsorption of Cationic and Anionic Dyes onto Shungite by Raman SpectroscopyA Raman spectroscopy method was used to assess the binding of dyes to different samples of carbon-bearing shungite rock with the same carbon content, but different mineral composition.
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Determination of Adsorption of Cationic and Anionic Dyes onto Shungite by Raman SpectroscopyA Raman spectroscopy method was used to assess the binding of dyes to different samples of carbon-bearing shungite rock with the same carbon content, but different mineral composition.
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A Convenient Alternative to MALDI and ESIAs was demonstrated by ESI and MALDI, and, more recently, ambient ionization approaches, successful new ionization methods can have an enormous impact on science. Novel ionization processes, such as inlet and vacuum ionization, are some of the latest of these approaches, and provide excellent alternatives to traditional approaches.
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High-Throughput Experimentation: Where Does Mass Spectrometry Fit?In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.
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Laser Thermal Desorption and GC×GC for Harsh Environment and Planetary Mass Spectrometry 16The development of analytical instrumentation for harsh terrestrial environments and outer planet space exploration exponentially increases instrument requirements-for features such as robustness, autonomous operation, and speed-and poses unique system integration challenges. Here, we explore the use of laser thermal desorption coupled to comprehensive two-dimensional gas chromatography (LTD-GC×GC) for use with a compact, high-resolution mass spectrometer for challenging applications.
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High-Throughput Experimentation: Where Does Mass Spectrometry Fit?In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.
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High-Throughput Experimentation: Where Does Mass Spectrometry Fit?In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.
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A Brief Review of Recent Advances in Isomeric N- and O-GlycomicsGlycan isomer expressions have not been well studied, due to inefficient separation and structural identification techniques. Fortunately, with the development of novel separation techniques and liquid chromatography–mass spectrometry (LC–MS) based glycan isomer identification strategies, new efforts have been made to investigate the glycan isomers in various diseases. Here, we review the recent advances of several isomeric separation techniques for both N- and O-linked glycans.
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A Brief Review of Recent Advances in Isomeric N- and O-GlycomicsGlycan isomer expressions have not been well studied, due to inefficient separation and structural identification techniques. Fortunately, with the development of novel separation techniques and liquid chromatography–mass spectrometry (LC–MS) based glycan isomer identification strategies, new efforts have been made to investigate the glycan isomers in various diseases. Here, we review the recent advances of several isomeric separation techniques for both N- and O-linked glycans.
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A Brief Review of Recent Advances in Isomeric N- and O-GlycomicsGlycan isomer expressions have not been well studied, due to inefficient separation and structural identification techniques. Fortunately, with the development of novel separation techniques and liquid chromatography–mass spectrometry (LC–MS) based glycan isomer identification strategies, new efforts have been made to investigate the glycan isomers in various diseases. Here, we review the recent advances of several isomeric separation techniques for both N- and O-linked glycans.
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Editors’ Series: Portable Spectroscopy in 2020What is the current state of portable spectroscopy instruments? What applications are these targeted at? What S/N levels can these instruments achieve? Can consumer-oriented instruments provide reliable information in the hands of non-expert users? Join us for this webcast to learn the answers to these questions and more. Live: Tuesday, Feb. 11, 2020 at 11am EST | 8am PST | 4pm GMT | 5pm CET On demand available after airing until Feb. 11, 2021 Register free
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The Application of FT-NIR and Multivariate Analysis Methods for Characterization of an Industrial Mold Purging ProcessNear infrared (NIR) reflection spectroscopy and multivariate analysis have been used to characterize materials relating to an injection mold barrel purging process. NIR was compared to attenuated total reflectance-mid-infrared (ATR-MIR) spectral measurements to assess whether the NIR measurement was relevant to either the surface or the bulk of the samples.
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The Application of FT-NIR and Multivariate Analysis Methods for Characterization of an Industrial Mold Purging ProcessNear infrared (NIR) reflection spectroscopy and multivariate analysis have been used to characterize materials relating to an injection mold barrel purging process. NIR was compared to attenuated total reflectance-mid-infrared (ATR-MIR) spectral measurements to assess whether the NIR measurement was relevant to either the surface or the bulk of the samples.
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Mid-IR Spectroscopy as a Primary Tool in Carbon Biogeochemistry ResearchMid-infrared spectroscopy is applied as a primary technique to better understand the bio- and ultraviolet-transformation of soil microbial biomass. Soil microbial biomass constitutes as much as 50% organic carbon in soil organic matter, and therefore plays a crucial role in soil-atmospheric chemistry. In this study, the spatial distribution of microbial-derived organic structures on kaolinite and montmorillonite clay minerals was investigated.
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The Application of FT-NIR and Multivariate Analysis Methods for Characterization of an Industrial Mold Purging ProcessNear infrared (NIR) reflection spectroscopy and multivariate analysis have been used to characterize materials relating to an injection mold barrel purging process. NIR was compared to attenuated total reflectance-mid-infrared (ATR-MIR) spectral measurements to assess whether the NIR measurement was relevant to either the surface or the bulk of the samples.
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Native Measurement of a Biotherapeutic without Interference from Excipients Using Microfluidic Modulation SpectroscopyA new infrared spectroscopy technique, microfluidic modulation spectroscopy (MMS), delivers reproducible protein characterization over close to four orders of magnitude in protein concentration (from 0.1 to 200 mg/mL). This technique characterizes samples from the earliest stages of development through to manufacture.
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Native Measurement of a Biotherapeutic without Interference from Excipients Using Microfluidic Modulation SpectroscopyA new infrared spectroscopy technique, microfluidic modulation spectroscopy (MMS), delivers reproducible protein characterization over close to four orders of magnitude in protein concentration (from 0.1 to 200 mg/mL). This technique characterizes samples from the earliest stages of development through to manufacture.
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Key Steps to Follow in a FRET ExperimentFörster resonance energy transfer (FRET) is a versatile part of the toolbox of fluorescence methods. This through-space, photon-less energy transfer process between a donor fluorophore and an acceptor chromophore is perhaps most famous for its utility as a “molecular ruler” that can resolve nanometer-scale distances. FRET is also a popular and advantageous basis for biomolecular assays and sensors.
