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High-Speed TERS Imaging: The Latest Achievements in nano-Raman SpectroscopyThis article presents developments in tip-enhanced Raman spectroscopy (TERS) that make possible nanoscale imaging of chemical and physical properties of graphene and other carbon species: Innovative integration of technologies brings high-throughput optics and high-resolution scanning for high-speed imaging without interferences between the techniques.
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In-Field Measurements of Major Elements and Base Metals with Handheld LIBSThe Z-500 also analyzes base metals and trade elements, including Mg, Ti, V, Cr, Fe, Mn, Cu, Ni, and others. Trace metals of commercial interest or as pathfinders including Li, Be, B, C, and halogens including F, Cl, and Br are also analyzed. Figure 2 shows results for Li analysis, as an example. The results for lithium analysis were reasonably good. While there is some scatter in the data, the HH LIBS is measuring very low concentrations, in the 10–30 ppm concentration range. In general, the results for B, Be, Mg, Ba, and other elements were comparable, in terms of correlation, with the Li data.
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Comprehensive Fragrance Profiling of Ginger, Wintergreen, and Rosemary Essential Oils by GC–TOF-MS with Soft Electron IonizationThis article investigates the use of gas chromatography–time-of-flight mass spectrometry (GC–TOF MS) to fragrance-profile three essential oils (ginger, wintergreen and rosemary). As well as considering the compositional differences between the oils, we will examine the use of peak deconvolution to identify closely-eluting compounds, and explore the use of soft electron ionization, assisted by comparison of ion ratios, to discriminate between isomeric monoterpenes that are difficult to identify at conventional 70 eV ionization energies due to their very similar mass spectra.
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X-ray Diffraction and Fluorescence Spectroscopy Analysis of Sm3+ in Lithium Calcium SilicateLuminescence materials are important for modern technology because of their ability to convert electromagnetic radiation (that is, ultraviolet [UV] and infrared [IR] light) into visible light (1).
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Detection of Melamine and Other Harmful Food Contaminants Using Gold Nanoparticles, Surface-Enhanced Raman Scattering, and Raster Orbital ScanningMelamine is a dangerous substance when it is used to increase the apparent protein content of food. In this article, the use of novel gold nanoparticles for surface-enhanced Raman spectroscopy (SERS) measurements with raster orbital scanning sampling is described for the detection of melamine and other food contaminants.
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A Sensitive and Cost-Effective LC–MS-MS Method for Determination of 1α,25-Dihydroxyvitamin D3 in Human PlasmaThe biologically active form of vitamin D is an important analytical target in both research and clinical practice.
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New Capabilities of High-Resolution Ultrasonic Spectroscopy: Titration AnalysisHigh-resolution ultrasonic spectroscopy titration analysis is a powerful new tool in research and analytical laboratory work for quantitative measurements of different processes and compounds. Here, the authors explore its potential.
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High-Speed TERS Imaging: The Latest Achievements in nano-Raman SpectroscopyThis article presents developments in tip-enhanced Raman spectroscopy (TERS) that make possible nanoscale imaging of chemical and physical properties of graphene and other carbon species: Innovative integration of technologies brings high-throughput optics and high-resolution scanning for high-speed imaging without interferences between the techniques.
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ICP-MS Analysis of Elemental Impurities in Oral Drug ProductsThis note describes using ICP-MS to analyze oral drug products in accordance with the accuracy, precision, and quantitative limits described in the JP, EP, and USP.
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A Rapid FT-IR-Based Method for Monitoring Detergent Removal from Biological SamplesIn life science research, detergents are primarily used in sample preparation to liberate cellular components through membrane disruption and to solubilize lipid-associated proteins.
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High-Speed TERS Imaging: The Latest Achievements in nano-Raman SpectroscopyThis article presents developments in tip-enhanced Raman spectroscopy (TERS) that make possible nanoscale imaging of chemical and physical properties of graphene and other carbon species: Innovative integration of technologies brings high-throughput optics and high-resolution scanning for high-speed imaging without interferences between the techniques.
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Raman Spectroscopy Coupled with Advanced Chemometrics for Forensic Analysis of Semen and Blood MixturesIn this study, regression and classification chemometrical algorithms were combined to achieve effective discrimination of pure body fluids from their binary mixtures.
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The Next Step in Targeted Drug Imaging for Oncology: Combining Laser-Induced Post-Ionization with MALDI ImagingOver the last decade, matrix-assisted laser desorption–ionization (MALDI) imaging has become an indispensable tool for a broad range of applications, from studying plant metabolomics to discovering biomarkers of disease to developing new therapies. As such, MALDI imaging is revolutionizing preclinical drug discovery pipelines by providing direct distribution monitoring of therapeutic compounds and their metabolites along with untargeted pharmacodynamic information. A key application of MALDI imaging is tissue analysis for oncology, and recent developments in MALDI technology promise greater benefits to cancer research. The combination of MALDI with laser-induced post-ionization (PI) enhances the detection and imaging of pharmaceutical compounds and other classes of compounds, allowing for significant advances in the use of MALDI imaging for studying drug metabolism and pharmacodynamics in tumor tissues. This article describes the value of MALDI Imaging for oncology applications and examines the potential for laser-induced PI, including the ability to achieve up to three orders of magnitude higher sensitivity and to image metabolite classes previously undetectable with traditional MALDI.
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Detection of Melamine and Other Harmful Food Contaminants Using Gold Nanoparticles, Surface-Enhanced Raman Scattering, and Raster Orbital ScanningMelamine is a dangerous substance when it is used to increase the apparent protein content of food. In this article, the use of novel gold nanoparticles for surface-enhanced Raman spectroscopy (SERS) measurements with raster orbital scanning sampling is described for the detection of melamine and other food contaminants.
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Analysis of Milk Powders Based on Chinese Standard Method Using the Agilent 5100 SVDV ICP-OESTrace toxic and major nutrient elements were measured in a single measurement in a milk powder SRM, with no ionization buffers, using a synchronous dual view ICP-OES. The methodology was in accordance with Chinese method GB 5413.21 for raw milk and dairy products. Excellent recoveries were achieved for all elements determined in the SRM, demonstrating the accuracy of the method over a large dynamic range.
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Ultra-Fast Determination of Trace Elements in Water, Conforming to US EPA 200.7 Using the Agilent 5100 SVDV ICP-OESThe productivity demands of environmental labs working to EPA methodology such as 200.7 for the determination of metals and trace elements in water, solids and biosolids are met using synchronous dual view ICP-OES. The instrumentation achieves an excellent sample-to-sample cycle time of 58 seconds. This enables more samples to be measured each day and reduces argon consumption per sample by 50% per sample.
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Radio Frequency Glow Discharge Optical Emission Spectroscopy: Depth Profiling Analysis of Thin Anodic Alumina Films as Potential Reference Materials (PDF)The need for reference materials that can be applied in the area of thin films analysis has long been realized but is still, in general, under-addressed. Alumina films of single-micrometer thickness, having either fine distributions of impurities or delta function impurity marker layers, can be prepared routinely by anodic oxidation of electropolished aluminum specimens in appropriate electrolytes. Selected films were examined by transmission electron microscopy (TEM) and analyzed by radio frequency glow discharge optical emission spectroscopy (rf-GD-OES), providing very rapid, yet high-resolution, depth-resolved analysis of these electrically insulating materials.
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Simultaneous Detection of Surface and Bulk Composition of a Magnesium AlloyIn this note, we examine a magnesium alloy plate to determine the type of anti?corrosion coating present. In the same experiment, the chemistry of the bulk magnesium alloy can also be observed. All data was collected using the ChemReveal® Desktop LIBS Analyzer.
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Detection of Trace Elements in High-Purity Sulfuric Acid Using Ultrasonic Nebulization with ICP-AES DetectionThis article discusses how coupling an inductively coupled plasma atomic emission spectrometer with an efficient ultrasonic nebulizer improves trace element detection in a 7.5% (v/v) high-purity sulfuric acid matrix.
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Savillex PFA Cyclonic Spray Chamber for ICP-OES and ICP-MSThe new Savillex PFA Cyclonic Spray Chamber is the first inert chamber with the traditional shape of a glass cyclonic, and is also the first translucent inert chamber.
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TLC-MALDI in Pharmaceutical Analysis (PDF)Thin-layer chromatography (TLC) is a widely used technique for the rapid examination of compound purity. The amount of qualitative information, however, is limited to the retention factor of compounds. The technique described here enables the direct determination of TLC plates by MALDI MS.
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Criteria for High-Quality Raman MicroscopyFive key qualitative factors–speed, sensitivity, resolution, modularity and upgradeability, and combinability–contribute to the quality of confocal Raman imaging microscopes. Using application examples, this article introduces modern Raman imaging and correlative imaging techniques, and presents state-of-the-art practice examples from polymer research, pharmaceutics, low-dimensional materials research, and life sciences.
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Solving Our Plastic Problem: Advances in Microplastics AnalysisModern society relies on plastic—However, it remains a mostly nonbiodegradable material and can take up to an estimated 400 years to break down depending on the type of plastic. This e-book examines the steps Agilent is taking to help address our plastic problem.
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Raman Spectroscopy Applied to the Lithium-Ion Battery AnalysisThe application note explains how the Raman Spectroscopy can be helpful in the analysis of cathodes and anodes in Li-ion batteries.
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Comparing Single Quadrupole with Triple Quadrupole GC–MS-Based MetabolomicsBruker Daltonics, Inc.
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Raman Spectroscopy is Solving the Perpetual Problem of CSI: The Time of a CrimeIn celebration of Spectroscopy’s 35th Anniversary, leading experts discuss important issues and challenges in analytical spectroscopy.
