An important attribute of a novel ionization process for use in mass spectrometry (MS) is its simplicity and flexibility to be hyphenated to conventional liquid-based separation methods.
An application of MALDI-MS in qualitative and quantitative analysis of pharmaceutical compounds spiked in urine is demonstrated.
An application of MALDI-MS in qualitative and quantitative analysis of pharmaceutical compounds spiked in urine is demonstrated.
A method is presented using IR and Raman microscopy to discriminate carbonate-containing and carbonate-free PVC that helps forensic scientists trace suspects, avoid wrong certificates of authenticity, and characterize and analyze carbonate components.
Demonstration of the advantages of using the Orbis micro-XRF elemental analyzer rather than other analysis techniques to perform elemental analysis through a plastic barrier and/or at atmospheric pressure.
A summary of the efforts to study microorganism biofilms using surface-enhanced Raman scattering, a powerful technique for in situ analysis of biological molecules and biomolecular organizations
A method is presented using IR and Raman microscopy to discriminate carbonate-containing and carbonate-free PVC that helps forensic scientists trace suspects, avoid wrong certificates of authenticity, and characterize and analyze carbonate components.
SERDS analysis can be easily and successfully carried out using two high-power laser diodes with a fixed-wavelength separation in the presence of high fluorescence.
Current USP Method 231 "Heavy Metals" was introduced in 1905 for determining heavy metal impurities in pharmaceutical drug products. The procedures of the method have several limitations, which produce results that are nondiscriminatory, difficult to reproduce, and qualitative, or at best, semi-quantitative.
A new sodium peroxide fusion method is described, as well as the conditions for inductively coupled plasma–optical emission spectrometry, and a list of the accuracy and precision measurements for all prepared samples.
The analysis of seals, mostly via the ink types, can provide evidence to authenticate the related documents and can play a key role in legal cases. In the present study, a method to discriminate red seal inks using Raman microscopy and Fourier transform infrared (FT-IR) spectroscopy was developed.
The structural complexity of monoclonal antibodies (mAbs) challenges the capabilities of even the most advanced chromatography and mass spectrometry techniques. This study examines the use of micro-pillar array columns in combination with mass spectrometry for peptide mapping of both mAbs and antibody–drug conjugates (ADCs).
The use of atomic spectroscopy techniques and sample preparation procedures is something that is not as routine in the pharmaceutical industry as are chromatography-based techniques and sample preparation procedures. With new requirements being implemented regarding elemental impurities by the United States Pharmacopoeia (USP) and International Conference on Harmonization (ICH), analysts in the pharmaceutical industry are, in many cases, working to determine how best to analyze their samples. Sample preparation techniques that can be used for pharmaceutical samples are the same ones that have been used by other industries for many years. This paper will provide a brief overview of potential techniques.
This method demonstrates that ICP-OES is a suitable alternative to ICP-MS for the determination of rare earth elements in geological and agricultural samples
An application of MALDI-MS in qualitative and quantitative analysis of pharmaceutical compounds spiked in urine is demonstrated.
Pharmaceutical samples spiked with several heavy metals were prepared for ICP-MS analysis using microwave digestion following the protocols in proposed USP chapters <232> and <233>. The results of the spike recovery study are discussed.
The measurement of trace elements is important across a wide variety of materials characterization problems. When measuring small glass fragments collected from crime and accident scenes, forensics experts analyze trace strontium (Sr) and zirconium (Zr) typically unintentionally incorporated into the glass during manufacturing as one point of identification or comparison.
Recent advances in thin-film filter technology have enabled dramatic improvements in the performance of filters for laser-based analytical instrumentation.
SERDS analysis can be easily and successfully carried out using two high-power laser diodes with a fixed-wavelength separation in the presence of high fluorescence.
This month's installment of "Column Watch" comprises Part II of our yearly report on new products introduced at Pittcon. Gas chromatography columns, sample preparation products, and hardware, accessories, and small tabletop instruments mainly for sample preparation are covered.
SERS of bacterial cells can be a useful technique for clinical diagnostics, as illustrated by the analysis of a human urine sample spiked with urinary tract infection bacteria.
A summary of the efforts to study microorganism biofilms using surface-enhanced Raman scattering, a powerful technique for in situ analysis of biological molecules and biomolecular organizations
Analysis of the temperature of the photosphere and determine the temperature by students using CCD spectrometers.
Teledyne Leeman Labs QuickTrace® M7600 was used to analyze and determine total elemental mercury (Hg0) concentration in Tuna (CRM 463) following the guidance in USDA Method CLG-MERC1.01 and the operating conditions.
A critical review of the main developments in instrument technology, calibration, and sample preparation that have made it possible to determine low sulfur concentrations in fuels followed by a discussion of strategies to minimize spectral interferences related to sulfur determination by ICP-MS, such as collision–reaction cells, high-resolution mass analyzers, and the interference standard method.
The authors show that dynamic reaction cell ICP MS can eliminate a number of argon- and carbon-based polyatomic interferences, allowing the determination of many critical elements in problematic organic compounds found in the semiconductor industry.
Analysis of the temperature of the photosphere and determine the temperature by students using CCD spectrometers.