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Latest:
Analysis of Nicotine Alkaloids and Impurities in Liquids for e-Cigarettes by LC–MS, GC–MS, and ICP-MSThe purpose of this study was the development of various analytical MS methods to investigate the chemical composition of e-liquids used in electronic cigarettes and characterize their quality. Low-quality nicotine (the main active compound), glycerol, propylene glycol (solvents), or flavors could greatly increase the toxicity. The search of alkaloid contaminants of nicotine was performed by LC–MS-MS after a deep study of fragmentation pathways by high resolution ESI-MS. A fully validated method for quantitation of organic polar impurities such as cotinine, anabasine, myosmine, nornicotine, and N-nitroso-nornicotine and nicotine itself was developed using MS coupled to UHPLC. To evaluate organic volatile toxicants, headspace from e-cigarette refill liquids was sampled by SPME to perform GC–MS analysis. Finally, heavy metal residues as inorganic toxicants were determined by ICP-MS after simple dilution. A number of cases of contamination by metals (mainly arsenic) was detected.
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Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
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Discrimination of Carbonate-Containing and Carbonate-Free Polyvinyl Chloride with Fourier Transform Infrared Microscopy and Raman SpectroscopyA method is presented using IR and Raman microscopy to discriminate carbonate-containing and carbonate-free PVC that helps forensic scientists trace suspects, avoid wrong certificates of authenticity, and characterize and analyze carbonate components.
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eBook: ‘Total Workflow’ Sample Prep ApproachThis eBook provides a deeper dive into the benefits of applying a ‘Total Workflow’ approach to sample prep for elemental analysis and the tools and methods that can be used to achieve those benefits.
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High Performance ICP-OES Sample Introduction: How to Choose and Use the Best Nebulizer for Your AnalysisNebulizer selection is a critical but often overlooked aspect of inductively coupled plasma–optical emission spectroscopy (ICP-OES) analyses. There are many different nebulizers available for ICP-OES, and choosing the optimal one can be confusing and difficult. To achieve peak performance from your ICP, it is essential to choose the proper nebulizer based on your sample types in addition to any necessary accessories to maintain long-term performance. In this study, we compare the performance of Glass Expansion’s most popular concentric nebulizer designs for ICP-OES applications as well as a parallel-path nebulizer from another vendor, providing a complete selection guide based on performance and design.
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Peptide Mapping of Monoclonal Antibodies and Antibody–Drug Conjugates Using Micro-Pillar Array Columns Combined with Mass SpectrometryThe structural complexity of monoclonal antibodies (mAbs) challenges the capabilities of even the most advanced chromatography and mass spectrometry techniques. This study examines the use of micro-pillar array columns in combination with mass spectrometry for peptide mapping of both mAbs and antibody–drug conjugates (ADCs).
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Microwave Digestion of Pharmaceutical Finished Products and Ingredients for Upcoming USP Method 233Current USP Method 231 "Heavy Metals" was introduced in 1905 for determining heavy metal impurities in pharmaceutical drug products. The procedures of the method have several limitations, which produce results that are nondiscriminatory, difficult to reproduce, and qualitative, or at best, semi-quantitative.
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Cost-Effective Analysis of Major, Minor, and Trace Elements in Foodstuffs Usint the 4100 MP-AESWhether the goal is food safety, ensuring quality, or establishing provenance, measuring the trace element content of foods and beverages that we all consume is of paramount importance. While some elements are essential for our well being at low concentrations, others like lead and chromium are highly toxic and more still are being linked to viral, neurological, and other diseases. Food scares related to contamination or poor quality not only constitute a health risk, they also undermine consumer confidence. This can lead to lost earnings through reduced sales and loss of credibility through adverse publicity.
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Multi-Wavelength Confocal Raman Microscope for Non-Destructive Pharmaceutical Ingredient AnalysisThe characterization of the active pharmaceutical ingredient (API) and its distribution and physical properties in commercial medicine is necessary in drug research and development process in the pharmaceutical industry. Among various analytical techniques employed for this purpose, Raman spectroscopy is gaining more popularity due to its advantages as non-destructive, non-invasive, fast spectrum acquisition in seconds, high reproducibility, and so on.
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Heavy Metals in Pet Food: Changes in Heavy Metal Contamination in Pet Food Over the Past DecadeAnalysis of heavy metals in pet food using ICP–OES was conducted to determine if there were potentially toxic elements present. Many of the samples showed significant concentrations of various toxic metals.
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IC–ICP–MS Speciation Analysis of As in Apple JuiceIn this study, apple juice samples are analyzed by IC–ICP–MS to determine the concentration of six arsenic species: the two inorganic, and highly toxic, species (As (V) and As [III]) and four organic species (arsenobetaine [AsB], arsenocholine [AsC], monomethylarsonic acid [MMA], and dimethylarsinic acid [DMA]).
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Comparison of Quadrupole, Time-of-Flight, and Fourier Transform Mass Analyzers for LC-MS Applications (PDF)The authors investigated the analytical capabilities of three types of mass analyzers for liquid chromatography-mass spectrometry (LC-MS) applications, studying the effects of instrument parameters and issues related to sample preparation on the performance of LC-MS analytical methods.
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Evaluation of Automated Solid-Phase Extraction for Nitrosamines Using US EPA Method 521Disinfection by-products (DBP) are an ever-present nuisance in the efforts to purify drinking water, wastewater, and municipal waters from various sources.
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Analysis of Wear Metals and Additive Package Elements in New and Used Oil Using the Optima 8300 ICP-OES with Flat Plate Plasma TechnologyThe Optima 8x00 ICP-OES series utilizes the new Flat Plate plasma technology that replaces the traditional helical coil design used since the inception of the inductively coupled plasma. The Flat Plate plasma technology, as seen in Figure 1, utilizes two flat induction plates to produce a plasma that is compact, dense, and robust. This plasma utilizes about half the argon required by previous helical coil designs while still delivering exceptional analytical performance.
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An Infrared Investigation of Nail Polish Remover Using Multiple Reflection Diamond ATRMultiple reflection ATR is ideal for detecting miniscule levels of components in solutions. If one component is volatile, trace analysis can be simplified by allowing the volatile liquids to evaporate.
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Observing the Solar Spectrum at House of ScienceAnalysis of the temperature of the photosphere and determine the temperature by students using CCD spectrometers.
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From Bakelite to Biodegradable: Practical Initiatives for Broadband Spectroscopy in Plastic Remediation and ReplacementSpectroscopy plays a critical role in both macroscopic and microscopic plastics detection, which is the first step in remediation, and also in the commercial replacement of plastics with biodegradable materials. This piece provides tangible examples of efforts being made today, including details on spectral hardware implementation, but more importantly provides proposals to the reader on how they can make a meaningful difference in their own world.
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Real-Time Chemometric Analysis of Multicomponent Bioprocesses Using Raman SpectroscopyIn this study, a glycerol-fed, lab-scale E. coli bioprocess producing representative pharmaceutical compounds was monitored offline with a portable, high-sensitivity Raman spectrometer.
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Discrimination of Carbonate-Containing and Carbonate-Free Polyvinyl Chloride with Fourier Transform Infrared Microscopy and Raman SpectroscopyA method is presented using IR and Raman microscopy to discriminate carbonate-containing and carbonate-free PVC that helps forensic scientists trace suspects, avoid wrong certificates of authenticity, and characterize and analyze carbonate components.
Latest:
Discrimination of Carbonate-Containing and Carbonate-Free Polyvinyl Chloride with Fourier Transform Infrared Microscopy and Raman SpectroscopyA method is presented using IR and Raman microscopy to discriminate carbonate-containing and carbonate-free PVC that helps forensic scientists trace suspects, avoid wrong certificates of authenticity, and characterize and analyze carbonate components.
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Gold Recovery from Used Ore by EDXRFThe measurement of gold is demonstrated in used ore material such as that from ore dumps and tailing piles. The recovery of uranium from the used ore material is also presented. The results how the Rigaku NEX DE EDXRF can achieve excellent results for monitoring and measuring the concentration of gold and other valuable elements in the recovery of used ore materials.
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2015 Salary Survey: Modest Gains, but Not for EveryoneThe latest Spectroscopy salary survey shows that the average salary has remained essentially static overall, which is welcome news after last year's drop. But not all sectors and groups are doing better.
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Ji-Xin Cheng Wins Pittsburgh Spectroscopy AwardJi-Xin Cheng of Boston University is the winner of the 2020 Pittsburgh Spectroscopy Award, which is presented by the Spectroscopy Society of Pittsburgh, a co-founder of the Pittcon conference. Established in 1957, the award honors an individual who has made outstanding contributions in the field of spectroscopy.
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Rapid and Direct Quantitation of Pharmaceutical Drugs from Urine Using MALDI-MSAn application of MALDI-MS in qualitative and quantitative analysis of pharmaceutical compounds spiked in urine is demonstrated.
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Elemental Analysis Through a Plastic BarrierDemonstration of the advantages of using the Orbis micro-XRF elemental analyzer rather than other analysis techniques to perform elemental analysis through a plastic barrier and/or at atmospheric pressure.
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Rapid Bacterial Diagnostics Via Surface-Enhanced Raman MicroscopySERS of bacterial cells can be a useful technique for clinical diagnostics, as illustrated by the analysis of a human urine sample spiked with urinary tract infection bacteria.
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Quick and Easy Dissolution of Chromite Ores, Ferrochromes, and Chromium Slags for ICP-OES without Using HF or HClO4A new sodium peroxide fusion method is described, as well as the conditions for inductively coupled plasma–optical emission spectrometry, and a list of the accuracy and precision measurements for all prepared samples.
