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Ion Mobility-Mass Spectrometry: A Tool for Characterizing the PetroleomeThe authors demonstrate the capacity to separate petroleum-derived molecules having the same nominal mass in the mobility dimension using IM-MS spectrometry.
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Accurate, Low-Level Sulfur Analysis by ICP-MS Using MS/MS with Oxygen Reaction Cell GasCombined with appropriate selection of instrument components to reduce the sulfur background, ICP-MS using MS/MS with oxygen reaction cell gas can provide accurate low-level analysis of sulfur and sulfur isotope ratios in aqueous and organic matrices. This is useful in applications in life science, clinical research, pharmaceutical development, food safety, environmental monitoring, geochemistry, and petrochemistry.
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A Dedicated Spectra Database for Multiline Selection in ICP-AESAcquisition and interpretation of a spectra database for ICP-AES analysis are described. The aim is the selection of nanometer-wide spectral windows containing several elements and several lines per element, so as to perform multiline analysis. An automatic line assignment procedure has been used. Information such as wavelength, sensitivity, line width, limit of detection, and level of detector saturation are stored. Filtering procedures are used for line selection, taking into account concentrations and possible spectral interferences.
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A Diamond ATR Study of Adhesives CuringMultiple reflection attenuated total reflection FT-IR accessory allows for protein analysis of strongly IR-absorbing samples, such as aqueous solutions.
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Tiny Wearable Raman SpectrometersTiny Wearable Raman Spectrometers for Direct and SERS Detections for the Real World!
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Raman Analysis of Embedded ContaminantsRaman confocal spectroscopy is increasingly being applied for the analysis of embedded contaminants within materials. A non-contact, non-destructive analysis method, Raman spectroscopy requires very little sample preparation, has greater spatial resolution compared to FT-IR microscopy and the confocal analysis method allows visualization of materials within a clear sample matrix. This paper will investigate the analysis of an embedded contaminant within a polymer matrix on a glass substrate.
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AccuTOF™ GC-Alpha for High-Performance GC-MSDiscover the superior performance of the AccuTOF™ GC-Alpha, designed to deliver ultimate performance and functionality for complex GC-MS analysis in industrial applications.
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Raman Confocal Analysis of an Inclusion in SapphireOne of the most powerful aspects of Raman microscopy is the capability to do confocal analysis of features inside of a sample without having to prepare or damage the sample to get the important spectral information.
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Forensic Application of Near-Infrared Spectroscopy: Aging of BloodstainsThe authors discuss the use of near-infrared spectroscopy to determine the age of a bloodstain, which can be critical in helping establish when a crime was committed.
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Native Measurement of a Biotherapeutic without Interference from Excipients Using Microfluidic Modulation SpectroscopyA new infrared spectroscopy technique, microfluidic modulation spectroscopy (MMS), delivers reproducible protein characterization over close to four orders of magnitude in protein concentration (from 0.1 to 200 mg/mL). This technique characterizes samples from the earliest stages of development through to manufacture.
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Rapid Chemical Threat Identification by SPME-GC–TMSA person-portable gas chromatography–mass spectrometry (GC–MS) system employing a toroidal ion trap mass spectrometry (TMS) detector was used to analyze chemical threat related compounds. Introduction of analytes into the heated injector of the instrument was by solid-phase microextraction (SPME), and fast resistive heating of a low thermal mass (LTM) gas chromatography column assembly provided rapid analysis times. Methodology for positive identification of chemical threats can combine chromatographic retention time, comparison to traditional electron ionization mass spectral libraries, and observation of expected pseudomolecular ions produced through self-chemical ionization. Methods are discussed for sampling by SPME with GC–MS analysis in the field to measure airborne analyte concentrations.
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New Approach for Optimizing a Monoclonal Antibody Biotherapeutic in Different FormulationsA prerequisite for a successful biotherapeutic formulation is one where the protein is stable and correctly folded. The new technique of dynamic multi-mode spectroscopy (DMS) was used to study the stability of a monoclonal antibody biotherapeutic formulated in acetate and lactate buffers. The samples were measured several times over a period of weeks and it became apparent that the antibody behaved differently as it aged in the two formulations, with the lactate formulation imparting greater robustness than the acetate.
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Analysis of Organic Compounds in Water Using Unique Concentration–Injection Techniques for Portable GC–MSA simple method for extraction and concentration of trace organic compounds found in water for gas chromatography-mass spectrometry (GC-MS) analysis was developed. The method used 25 and 45 mL glass vials with a 5-10 µm thick polymer coatings for extraction of analytes from 20 and 40 mL water samples, respectively. Analytes were subsequently transferred from the polymer coating into an organic solvent, which was reduced in volume to 200-400 µL for analysis. A 10-20 µL sample from the vial was transferred to a tiny coiled stainless steel wire filament using a micro-syringe, or by dipping the coil into the sample. After air evaporation of the solvent, the coil was inserted into the heated injection port of a portable GC-MS system where the analytes were desorbed. Injection using the coiled wire filament eliminated sample discrimination of high boiling point compounds, and minimized system contamination caused by sample matrix residues. The GC-MS contained a new resistively heated column bundle that allowed elution of low-volatility compounds in less than 4 min. Analyses of organochlorine pesticides, polycyclic aromatic hydrocarbons, polychlorinated biphenyl congeners, pyrethroid insecticides, phthalate esters, and n-alkanes in water and wastewater samples were accomplished for low ppb concentrations in less than 10 min total analysis time.
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PittCon 2002 Review (PDF)Spectroscopy's annual overview of new instrumentation presented at the PittCon conference.
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Pesticide and Mycotoxin Analysis: Mastering the Complexity of the Cannabis MatrixThe method described here allows for the simultaneous analysis of 47 pesticides and five mycotoxins in cannabis in one simple QuEChERS procedure. This simple method is designed for implementation in start-up laboratories and in established laboratories that wish to streamline their sample preparation process, decrease solvent usage, and obtain accurate and fast results.
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Portable Transmission FTIR Analysis of Volatile Samples Using the DialPath Liquid CellTraditionally the analysis of volatile liquids by FTIR spectroscopy has always entailed a sealed fixed pathlength cell.
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Do We Qualify or Validate a Spectrometer?We critically review the qualification and validation approaches in the World Health Organization Technical Report Series (WHO TRS) 1019 Annex 3 and its applicability to spectrometer systems.
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The 2002 Spectroscopy Survey of Salaries and Employment Issues (PDF)A Look at Spectroscopists' Incomes and Attitudes about Their Jobs
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Recent Improvements in Benchtop GC–MSThe 30-year history of advances in gas chromatography–mass spectrometry technology continues today. Recent improvements in hardware, electronics, and data analysis software have resulted in new levels of productivity and sensitivity that have broadened the potential applications for this laboratory mainstay.
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Book Review: Atomic Spectroscopy in Elemental Analysis, MIchael Cullen, ed., (Blackwell Publishing, 2004) [PDF]This book covers most of the popular atomic spectroscopy methods used for the determination of the elemental composition of materials.
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Simple and Effective Control of Spectral Overlap Interferences in ICP-MSThe authors discuss a new approach to the control of spectral overlap interferences in inductively coupled plasma–mass spectrometry.
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Rapid Multielement Nanoparticle Analysis Using Single-Particle ICP-MS/MSComplex isobaric and polyatomic spectral interferences can be mitigated using triple quadrupole ICP-MS (ICP-MS/MS) with a collision–reaction cell (CRC). This configuration allows for the multielement characterization and detection of smaller nanoparticle sizes.
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Photovoltaic Device Characterization Using the UVISEL Spectroscopic EllipsometerHORIBA Jobin Yvon, Inc.
