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Ultratrace Aluminum Analysis of Nutritional Intravenous Solution Components in 1-Propanol Using GFAAS (PDF)This article describes how ultratrace aluminum analysis of two nutritional intravenous solution components with limited water solubility can be performed by graphite furnace atomic absorption spectroscopy (GFAAS) with dissolution in 1-propanol.
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From Tablets to Teeth: Complete Raman ImagingRaman imaging has moved on. It is now possible to capitalize on the wealth of information available from a Raman spectrum by imaging materials over large areas, with the spatial resolution, spectral resolution, and laser excitation parameters tailored to suit each application. Raman experiments and images from a diverse range of samples are presented.
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Complete Multielemental Analysis of Environmental and Geological Samples Using CCT-Based ICP-MSThe authors discuss the ICP-MS method, its usability in environmental and geological analysis and relevant regulations, and how to address its limitations.
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A Comprehensive Study of WSe2 Crystals Using Correlated Raman, Photoluminescence (PL), Second Harmonic Generation (SHG), and Atomic Force Microscopy (AFM) ImagingUsing confocal Raman imaging and other advanced measurement techniques, we study the localized strain characteristics of tungsten diselenide (WSe2), an important nanomaterial used for optoelectronic device applications.
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Synthesis and Structural Elucidation of Impurities in Ramipril TabletsIn this article, the authors take a look at the identification, synthesis, and characterization of impurities in Ramipril tablets.
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Combining Raman Spectroscopy and Differential Scanning CalorimetryRaman spectroscopy and differential scanning calorimetry (DSC) are powerful techniques in their own right. Combining the two techniques allows one to combine the chemical and structural information of Raman with the temperature and energetic information of DSC. This allows us to develop a greater understanding of the material. Applications from polymeric and pharmaceuticals are discussed as examples of how this can help the analyst.
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The Role of Triple Quadrupole GC–MS in Steroid AnalysisThe authors discuss the use of GC-MS in drug doping testing.
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Portable, High-Efficiency Transmission Raman Spectroscopy for At-Line Content Uniformity Testing of Pharmaceutical TabletsPortable transmission Raman spectroscopy, combined with chemometric modeling, is quickly emerging as a valued technique for content-uniformity testing, given its high chemical specificity, which is particularly useful when dealing with complex pharmaceutical formulations that contain multiple components.
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The Use of Liquid Chromatography with Tandem Mass Spectrometry for the Analysis of Emerging Environmental ContaminantsMany organic chemicals are difficult to analyze using traditional GC–MS. In this study, the author used LC–MS-MS to analyze a variety of environmental contaminants.
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Structured Approach to Method Development for Bioanalytical HILIC–MS-MS ApplicationsA structured, general purpose approach to method development for bioanalytical hydrophilic interaction chromatography–tandem mass spectrometry (HILIC–MS-MS) applications is described.
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High-Resolution Ultrasonic Spectroscopy: Analysis of Microemulsions (PDF)This article introduces the application of high-resolution ultrasonic spectroscopy for the analysis of emulsions and suspensions.
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Rapid Identification of Illicit and Prescription Drugs Using FT-NIR SpectroscopyThe authors discuss the use of FT-NIR to identify several different types of drug formulations.
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Interaction of Dichloromethane Solvent with n-Alkylamines Analyzed by Electron Ionization GC–MSThe analysis of amines by gas chromatograph ;mass spectrometry (GC–MS) using electron ionization (EI) has always been a challenge
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Evaluation of Modified QuEChERS for Pesticide Analysis in CannabisWell-established techniques used by the food safety industry, such as QuEChERS sample preparation followed by LC–MS/MS for the analysis of multiresidue pesticides, are evaluated for use with cannabis plant material.We evaluated a modified QuEChERS LC-MS/MS method for analysis of multiresidue pesticides.
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Using High-Resolution LC–MS to Analyze Complex SampleThe authors discuss the use of high-resolution LC-MS to analyze complex samples in regulated environments such as food and animal-feed analysis.
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High-Speed Analysis of b-Blockers and Metabolites in Human Plasma by LC–ESI-MS-MS with High-pH Mobile PhaseBeta-blockers are basic compounds that contain a secondary amino group in their structure. The amino substituents are typically an isopropyl group and a larger chain with a hydroxyl group in the beta position from the nitrogen atom (Table I). The simultaneous analysis of ?-blockers in biological samples is meaningful, and is made possible by the similarities in their structure. Gas chromatography (GC)–mass spectrometry (MS) has been the most used technique for their identification and quantification (4–6). However, most ?-blockers are nonvolatile and thus require derivatization via a cumbersome and time-consuming process before GC–MS analysis. In recent years, liquid chromatography (LC) coupled with mass spectrometric detection has evolved as the method of choice for drug analysis in the pharmaceutical, clinical, and forensic toxicology areas (4–8). In contrast to GC–MS, LC–MS-MS generally does not require derivatization and offers superior sensitivity. Moreover, due to the high specificity offered by LC–MS-MS, baseline chromatographic resolution often is not required, allowing for fast analysis in high-throughput environments.
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Evaluation of Modified QuEChERS for Pesticide Analysis in CannabisWell-established techniques used by the food safety industry, such as QuEChERS sample preparation followed by LC–MS/MS for the analysis of multiresidue pesticides, are evaluated for use with cannabis plant material.We evaluated a modified QuEChERS LC-MS/MS method for analysis of multiresidue pesticides.
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Shedding Light on DNA Analysis: Multiplexed Detection and Identification Using Fluorescence Lifetime Methods (PDF)This article provides a review of using both time- and phase-resolved fluorescence for DNA analysis in both sequencing and microarray applications.
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Magnet or Cell? A Comparison of High-Resolution Sector Field ICP-MS and Collision–Reaction Cell Quadrupole ICP-MSInductively coupled plasma–mass spectrometry (ICP-MS) is a mature method that offers reliable measurements across almost the entire periodic table. It has been established as the key methodology for investigating elemental concentrations, which play a central role in biological, environmental, chemical, and industrial processes. ICP-MS is capable of performing multielemental analyses in a single analytical run, achieving an overall productivity of more than 50 samples/h. The method also delivers lower detection limits compared to graphite furnace atomic absorption (GFAA) or inductively coupled plasma–optical emission spectrometry (ICP-OES).
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Comprehensive Screening, Confirmation, and Quantification of Organic Pesticides in Foods by GC–MS and LC–MSThis article provides an overview of the instrument platforms, tools, and workflow for analyzing pesticides.
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Gaining Insight into Cocoa Butter Polymorph Formation Through In Situ Rheology and Raman SpectroscopyThe hyphenation of rheology and Raman spectroscopy enabled a more holistic depiction of the crystallization process and provided unique insights into the formation of cocoa butter polymorph form IV.
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Structured Approach to Method Development for Bioanalytical HILIC–MS-MS ApplicationsA structured, general purpose approach to method development for bioanalytical hydrophilic interaction chromatography–tandem mass spectrometry (HILIC–MS-MS) applications is described.
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A Dedicated Spectra Database for Multiline Selection in ICP-AESAcquisition and interpretation of a spectra database for ICP-AES analysis are described. The aim is the selection of nanometer-wide spectral windows containing several elements and several lines per element, so as to perform multiline analysis. An automatic line assignment procedure has been used. Information such as wavelength, sensitivity, line width, limit of detection, and level of detector saturation are stored. Filtering procedures are used for line selection, taking into account concentrations and possible spectral interferences.
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A Simplified Approach to Optimize SPE Method Development with Downstream LC–MS Analysis Allowing 100% Organic, Basified Injection SolventsHere, the authors demonstrate the use of a systematized approach to SPE method development and LC–MS-MS analysis.
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Dosing Vehicle Removal in Discovery Phase Pharmacokinetic Studies Using High-Field Asymmetric Waveform Ion Mobility SpectrometryThis article describes the ability to increase the sensitivity for a target compound in the presence of high-level background impurities by removing the dosing vehicle using a high-field asymmetric waveform ion mobility spectrometry gas-phase separation before mass spectrometry analysis.
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A Simplified Approach to Optimize SPE Method Development with Downstream LC–MS Analysis Allowing 100% Organic, Basified Injection SolventsHere, the authors demonstrate the use of a systematized approach to SPE method development and LC–MS-MS analysis.
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A Dedicated Spectra Database for Multiline Selection in ICP-AESAcquisition and interpretation of a spectra database for ICP-AES analysis are described. The aim is the selection of nanometer-wide spectral windows containing several elements and several lines per element, so as to perform multiline analysis. An automatic line assignment procedure has been used. Information such as wavelength, sensitivity, line width, limit of detection, and level of detector saturation are stored. Filtering procedures are used for line selection, taking into account concentrations and possible spectral interferences.
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Single-Particle Spectroscopy on Conducting Polymer-Fullerene Composite Materials for Application in Organic Photovoltaic DevicesThe study of the photophysical and optoelectronic properties of a functioning conducting polymer device is complicated and is hampered by the complex nanostructure and morphology of the conducting polymer materials in these devices. Here we discuss an approach to investigate this issue in terms of bulk-heterojunction organic photovoltaic devices.
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LC–MS-MS Determination of Malachite Green and Leucomalachite Green in Fish ProductsAlthough not currently used in U.S. or European aquaculture, malachite green (MG) is still an effective and inexpensive fungicide that is used in other countries, particularly in Asia. During metabolism, MG reduces to leucomalachite green (LMG) (Figure 1), which has been shown to accumulate in fatty fish tissues. Trace levels of MG and LMG residues continue to be found in fish products. In a 2005 report, MG was found in 18 out of 27 live eel or eel products imported from China to Hong Kong local market and food outlets, resulting in a government recall and destruction of all remaining products (1).
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LC–MS-MS Determination of Malachite Green and Leucomalachite Green in Fish ProductsAlthough not currently used in U.S. or European aquaculture, malachite green (MG) is still an effective and inexpensive fungicide that is used in other countries, particularly in Asia. During metabolism, MG reduces to leucomalachite green (LMG) (Figure 1), which has been shown to accumulate in fatty fish tissues. Trace levels of MG and LMG residues continue to be found in fish products. In a 2005 report, MG was found in 18 out of 27 live eel or eel products imported from China to Hong Kong local market and food outlets, resulting in a government recall and destruction of all remaining products (1).
