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Applications of Raman Spectroscopy in Solvent Distillation and Exchange During Early-Phase Chemical SynthesisThe case studies presented here successfully demonstrate the use of inline Raman spectroscopic analysis to estimate solvent content during the solvent exchange and distillation operations in the synthesis of active pharmaceutical ingredients.
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Imaging of Trace Elements Using Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry: Emerging New ApplicationsMetallomics seeks to understand the metallobiochemistry of cells and organisms in health and disease. This article explains the principle of laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) for imaging applications and highlights its potential to provide additional insights in bioanalysis and metallomics.
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In-situ Detection of Rice Using Laser Induced Breakdown Spectroscopy and Machine LearningThis research investigates the application of laser-induced breakdown spectroscopy (LIBS) and machine learning (ML) for detecting elemental composition of food, using rice as an example.
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High-Resolution High-Speed LIBS MicroscopyThe use of high-resolution LIBS imaging requires the reduction of acquisition time. The authors describe a new developed system that accomplishes this goal and can be used in various applications where elemental composition and elemental distribution analysis is required.
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High-Resolution High-Speed LIBS MicroscopyThe use of high-resolution LIBS imaging requires the reduction of acquisition time. The authors describe a new developed system that accomplishes this goal and can be used in various applications where elemental composition and elemental distribution analysis is required.
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Rapid Quantitative Method in the Determination of Total Flavonoids in Tibetan Medicine Meconopsis integrifolia (Maxim.) Franch. from Qinghai-Tibet Plateau by Near Infrared SpectroscopyThis study aimed to establish a fast, accurate method for quality evaluation of herbal medicine using NIR and chemometrics with ultraviolet-visible spectrophotometry (UV-vis) as a standard method to determine the total flavonoids content.
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Rapid Quantitative Method in the Determination of Total Flavonoids in Tibetan Medicine Meconopsis integrifolia (Maxim.) Franch. from Qinghai-Tibet Plateau by Near Infrared SpectroscopyThis study aimed to establish a fast, accurate method for quality evaluation of herbal medicine using NIR and chemometrics with ultraviolet-visible spectrophotometry (UV-vis) as a standard method to determine the total flavonoids content.
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FTIR Spectroscopy for Multi-species Gas AnalysisResearchers at Heriot-Watt University deploy the Chromacity OPO for active long-range FTIR spectroscopy to acquire high-resolution gas absorption spectra over 200 m.
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Imaging of Trace Elements Using Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry: Emerging New ApplicationsMetallomics seeks to understand the metallobiochemistry of cells and organisms in health and disease. This article explains the principle of laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) for imaging applications and highlights its potential to provide additional insights in bioanalysis and metallomics.
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Chemical Vapor Generation Non-Dispersive Atomic Fluorescence Spectrometry Technique for the Determination of Arsenic, Antimony, Selenium, and Mercury in Geological Samples by One-Time DigestionIn this paper, a one-time digestion method for the determination of arsenic (As), antimony (Sb), selenium (Se), and mercury (Hg) in geological samples was established.
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A Brief Look at Optical Diffuse Reflection (ODR) SpectroscopyIn this short overview, we consider cases for diffuse reflection spectroscopy and introduce the Kubelka-Munk diffuse reflectance formula. We conclude by comparing diffuse transmittance, diffuse reflectance, logarithmic transforms of both, and the Kubelka-Munk transform for mid-infrared spectroscopy of the same sample.
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Multiscale Convolutional Neural Network of Raman Spectra of Human Serum for Hepatitis B Disease DiagnosisA multiscale convolutional neural network (MsCNN) was used to screen Raman spectra of the hepatitis B serum, achieving higher classification accuracy compared to traditional machine learning methods.
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Reliable Chemical Analysis of Aerosols by Reference-Free X-ray Spectrometry for Monitoring Airborne Particulate MatterThis approach provides traceable and reliable quantitative elemental analysis of airborne particles for on-site environmental measurement with portable instrumentation.
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Evaluation and Development Trends of Optical Detection Technology for Seed VigorIn this article, the basic principles, advantages, and limitations of different optical techniques for obtaining seed vigor estimates are introduced and reviewed, and the key technology of non-destructive optical detection of single seeds will be discussed.
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Multimode vs Single-Mode Lasers for RamanWe tackle one of the most common questions to arise when picking a Raman spectroscopy laser, “Should I choose a single, or multi-spatial mode laser for my application?”
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High-Throughput Profiling of Long Chain Fatty Acids and Oxylipins by LC–MSLong chain fatty acids (LCFAs) function as a source of metabolic energy, substrates for membrane biogenesis, and storage of metabolic energy. Oxylipins, oxygenated derivatives of LCFAs, regulate the activity of many cellular processes. Existing methods for the analysis of LCFAs and oxylipins have limited compound coverage and sensitivity that, therefore, prevent their application in biological studies. In this work, we developed a high-throughput LC–MS method for analysis of 51 LCFAs and oxylipins. LCFAs and oxylipins were first extracted from biological samples via solid-phase extraction. The extracted molecules were analyzed by targeted comparative metabolomics. Saturated and monounsaturated LCFAs were analyzed in single ion reaction mode, while polyunsaturated LCFAs and oxylipins were analyzed in multiple reaction monitoring mode. Using this method, we successfully quantified 31 LCFAs and oxylipins from mouse livers.
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Technological Analysis of Glazed Tiles Unearthed from Bao’ensi in NanjingUV-Vis-NIR can be used to understand how ancient buildings were constructed. Here, a UV-Vis-NIR and EDXRF spectrophotometer were used to analyze glazed tiles that comprised a historical site built in Ancient China.
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Raman Spectroscopy as a Tool for Rapid Feedback of Perovskite Growth Crystallinity and CompositionPerovskites are known to be useful for fabrication of solar cells, and their crystalline structure plays an important role in their electronic properties. Here, we show how Raman analysis is able to confirm the presence of the required crystalline phase for solar cell production.
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Model for Retrieving Leaf Chlorophyll Using the Wavelet Analysis Algorithm with the Prospect Radiative Transfer Model and Vis-NIR SpectraSpectral reflectance is a non-destructive method that is applicable to remote sensing and may be used to measure the chlorophyll content in a crop, which indicates the photosynthetic capacity, growth cycles, and degrees of stress (such as disease, insect infestation, and heavy metal stress) on plant ecosystems. This vis-NIR spectral reflectance method measures leaf chlorophyll using a wavelet analysis algorithm approach.
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Real-World Application of Open-Path UV-DOAS, TDL, and FT-IR Spectroscopy for Air Quality Monitoring at Industrial FacilitiesThe implementation of 120 open-path spectroscopy analyzers at oil refineries has taught us lessons about compound identification, target species detectability, interferences, and data management, which can help spectroscopists generate more accurate data when monitoring air quality.
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Monitoring for Per- and Poly-Fluoroalkyl (PFAS) with Advanced Mass Spectrometry– Based MethodsPer- and poly-fluoroalkyl substances (PFAS) are a family of potentially thousands of synthetic compounds that have long been used in the manufacture of a variety of common products with stain-repellent and nonstick properties. Their signature strong fluorine and carbon bonds make them difficult to break down and, as a result, they are among the most persistent of today’s environmental pollutants. Alarmingly, PFAS can be found in drinking water and have been shown to accumulate in the body with the potential to cause multiple health problems, such as hormone disruption and cancer. Advances in mass spectrometry have facilitated the detection of known PFAS contaminants as well as the identification of poorly studied and novel compounds in watersheds. This article explores the detection of known and novel PFAS contaminants in aqueous film-forming foams and raw drinking water sources in North Carolina, using new advances in mass spectrometry and data acquisition to improve identification and quantitation.
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A Facile Synthesis of Tannic Acid–Protected Copper Nanoclusters and the Sensitive Fluorescence Detection of Nitrite Ion Under Mild ConditionsNitrite poses health risks. This study evaluates the results of using tannic acid- protected fluorescence copper nanoclusters (TA-CuNCs) to detect nitrite in food.
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Terahertz Spectral Characterization of Plasma Spray–Deposited Nickel Film on an Alumina CylinderPlasma spray–deposited metal films are used in many industrial applications. This study shows how high resolution terahertz time-domain spectroscopy (THz-TDS) can be used to analyze and characterize such films.
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Spectroscopy and Spectroscopic Analytical Techniques in the United States Pharmacopeia–National Formulary (USP–NF)The United States Pharmacopeia–National Formulary (USP–NF) has contributed to ensuring the quality of dietary supplements, foods, and medicines for more than 200 years. This overview explains the use of vibrational spectroscopy techniques in meeting USP–NF requirements and how the information is organized.
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Towards Automated Routine Analysis of the Distribution of Trace Elements in Single Cells Using ICP-MSAnalysis of the compositional variation in living cells is essential for understanding biological processes. Single-cell elemental analysis by triple-quadrupole ICP-MS is emerging as a selective, highly sensitive, and potentially high-throughput technique for the study of constitutive elements, and uptake of metallodrugs (or metal-containing nanomaterials) in single cells.
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Detecting Chicken Freshness Utilizing VNIR, SWIR Spectroscopy, and Data FusionThis study uses hyperspectral imaging (HSI) technology, in synergy with machine learning and deep learning algorithms, to innovate a non-destructive method for the assessment of chicken freshness.
