Raman Spectroscopy

Our annual review of new products for atomic and molecular spectroscopy, including details by category and highlights of overarching trends.

SERS of centrifuged blood serum samples of diabetic type II patients using 50 KDa filter devices can diagnose the disease at an early stage by studying small molecular weight proteins.

The DeepRaman method proposed in the study is an accurate, universal, and ready-to-use method for component identification in various application scenarios.

An overview of Raman spectroscopy and its applications in pharmaceutical analysis is presented.

The researchers believe that the results of this study can contribute to the development of more effective and safer approaches to reduce the toxicity of heavy metals in food and the environment.

Dmitry Kurouski has won the 2023 Emerging Leader in Molecular Spectroscopy Award for his molecular spectroscopy studies revolving around plants.

A Raman calibration model was created to study cell cultures.

According to new research, two new Raman spectroscopy approaches, reducing a spectrum complexity (RSC) and multivariate curve resolution combined with the additions method (MCRAD), can detect bloodstains on a multitude of well-known substrates, with RSC proving to be the more effective technique.

According to the study, partially oxidized Ag nanowires can provide high ethanol selectivity for carbon dioxide electroreduction.

A deep learning model for predicting the size-dependent Raman shift of semiconductor nanomaterials was demonstrated and achieved via multi-layer perceptron.

Webinar Date/Time: Europe: Tuesday, 28 March, 2023 at 1pm BST | 2pm CET North America: Tuesday, 28 March, 2023 at 11am PDT | 1pm CDT | 2pm EDT Asia: Wednesday, 29 March, 2023 at 10:30am IST | 1pm SGT | 2 pm JST | 4pm AEDT

The United States Pharmacopeia–National Formulary (USP–NF) has contributed to ensuring the quality of dietary supplements, foods, and medicines for more than 200 years. This overview explains the use of vibrational spectroscopy techniques in meeting USP–NF requirements and how the information is organized.

Combining multiplex coherent anti-Stokes Raman scattering (MCARS) microscopy with automated data processing enables a simple and more accessible method for label-free bioimaging.

The significance of the smaller spectral region of the Raman spectrum, defined as the “fingerprint in the fingerprint” region, cannot be overstated when it comes to active pharmaceutical ingredient identity testing (API).

Glycoproteins are becoming popular in the pharmaceutical industry, prompting the need for an effective spectroscopic technique that can differentiate them. SERS is one such technique ideal for glycan analysis for several key reasons, which are discussed here.

Webinar Date/Time: Thu, Feb 23, 2023 11:00 AM EST

Handheld FT-Raman spectroscopy can complement GC–MS and IR in characterizing street drugs.

Extractables and leachable are typically studied using chromatographic techniques. This study explores what we can learn by using from using Raman microscopy for such studies.

In the treatment of tuberculosis (TB), a contagious disease that causes 1.5 million deaths per year globally, early diagnosis is critical in order to control its spread. Unfortunately, standard tuberculosis diagnostic tests, such as sputum culture, can take days to weeks to yield results. In a recent paper, Ubaid Ullah of the Syed Babar Ali School of Science and Engineering in Pakistan and his colleagues demonstrate a quick, portable, easy-to-use, and non-invasive optical sensor based on sputum samples for tuberculosis detection using Raman spectroscopy to detect TB in a patient’s sputum supernatant. Ullah spoke to Spectroscopy about this sensor and its development.

In the past 20 years, spectrometers have shrunk dramatically in size, and this shrinking has been achieved with only modest performance reductions in sampling versatility, spectral range, spectral resolution, and signal-to-noise.

The results of this study showed that orbital raster scanning (ORS) technology, which ensured a greater interrogation area, also resolved issues of conventional Raman spectroscopy, such as low spectrum intensity and resolution.

This study examines whether the computed spectrum can be used to accurately identify amino acids, by comparing the computer spectrum to the measured spectrum of a biological sample.

Karen Faulds of the University of Strathclyde co-authored a paper where SESORS signals could be detected from nanotags at depths down to 48 mm for the first time using a handheld spatially offset Raman (SORS) instrument. She recently spoke to Spectroscopy about this and some of her other papers and the advances in the science that made them possible. Faulds is the 2022 recipient of the RSC Analytical Division Mid-Career Award. This interview is part of an ongoing series of interviews with the winners of awards that are presented at the annual SciX conference, which will be held this year from October 2 through October 7, in Covington, Kentucky.

Raman and XRF spectroscopy were used to examine paint in artwork, revealing the potential of both techniques to verify the authenticity of famous works of art.

James Piret, and Robin Turner, of Michael Smith Laboratories (Vancouver, BC Canada) and the University of British Columbia (UBC) have been exploring the benefits of extracting and displaying correlated spectrometric and non-spectrometric variables with a proposed method called multisource correlation analysis (MuSCA). Their work has uncovered several advantages of using Raman spectroscopy for these applications. Here, they discuss their efforts to develop an approach that permitted the integration of diverse biochemical information with measured spectra for co-analysis to characterize the spectra and take advantage of the available spectral information.

Wei Min, of the Department of Chemistry at Columbia University in New York City, and his associates recently published a paper outlining their devising a set of multiplexed Raman molecular probes with sharp and mutually resolvable Raman peaks to simultaneously quantify cell surface proteins, endocytosis activities, and metabolic dynamics of an individual live cell. Min, who recently spoke to us about this work, is the 2022 recipient of the Craver Award, presented annually at FACSS SciX to recognize the efforts of young professional spectroscopists that have made significant contributions in applied analytical vibrational spectroscopy.

In this study, in situ Raman spectroscopy was used to detect the formation, growth, and evolution of corrosion inside a salt fog chamber. These results pave the way for monitoring the real-time observation of corrosion on metal surfaces.

Here, we explain how Raman spectroscopy is valuable for characterizing industrially important carbon materials.

As an alternative drug delivery route, transdermal patches control the amount of medication a patient receives. With confocal Raman microscopy it is possible to create a Raman 3D map and thus visualize and analyze the layers of a transdermal patch without damaging it, allowing for quality control and stability measurements.

In this second part of this four-part series on spectroscopy instrument components, we take a closer look at optical components or subassemblies used for vibrational spectroscopy instruments.