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Fluorescence Quenching Effects of Fe3+ Ions on Carbon DotsThe “selective fluorescence quenching effects” of Fe3+ ions on carbon dots are examined to gain a more comprehensive understanding of the interactions of metal ions with a variety of fluorescent materials.
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Gas Chromatography–Mass Spectrometry (GC–MS) with Cold Electron Ionization (EI): Bridging the Gap Between GC–MS and LC–MSGas chromatography–mass spectrometry (GC–MS) with cold electron ionization (EI) is based on interfacing the GC and MS instruments with supersonic molecular beams (SMB) along with electron ionization of vibrationally cold sample compounds in SMB in a fly-through ion source (hence the name cold EI). GC–MS with cold EI improves all the central performance aspects of GC–MS. These aspects include enhanced molecular ions, improved sample identification, an extended range of compounds amenable for analysis, uniform response to all analytes, faster analysis, greater selectivity, and lower detection limits. In GC–MS with cold EI, the GC elution temperatures can be significantly lowered by reducing the column length and increasing the carrier gas flow rate. Furthermore, the injector temperature can be reduced using a high column flow rate, and sample degradation at the cold EI fly-through ion source is eliminated. Thus, a greater range of thermally labile and low volatility compounds can be analyzed. The extension of the range of compounds and applications amenable for analysis is the most important benefit of cold EI that bridges the gap with LC–MS. Several examples of GC–MS with cold EI applications are discussed including cannabinoids analysis, synthetic organic compounds analysis, and lipids in blood analysis for medical diagnostics.
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Applications of Raman Spectroscopy in Solvent Distillation and Exchange During Early-Phase Chemical SynthesisThe case studies presented here successfully demonstrate the use of inline Raman spectroscopic analysis to estimate solvent content during the solvent exchange and distillation operations in the synthesis of active pharmaceutical ingredients.
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Porous Chitosan Composite Membrane Tandem Laser-Induced Breakdown Spectroscopy for Detection of Metal Elements in Liquid SamplesDetecting metal elements in liquid samples cannot be done efficiently by only using LIBS, but when the technique is combined with appropriate membrane materials, rapid analysis of solution samples can be realized.
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Spectral Sensing Using a Handheld NIR Module Based on a Fully Integrated Sensor ChipA novel approach to NIR spectral sensing, using a miniaturized fully-integrated multipixel array of resonant-cavity-enhanced InGaAs photodetectors, enables sensors with a millimeter-scale footprint and wafer-scale fabrication. This multipixel sensor does not measure the full spectrum, but rather a limited number of spectral regions with limited resolution (50–100 nm).
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Cleaning Up Cannabis: Identifying Sources of Inorganic Contamination & ErrorWebinar Date/Time: Mon, Mar 27, 2023 11:00 AM EDT
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Identifying Doxycycline Hydrochloride and Tylosin in Chicken Using Surface-Enhanced Raman SpectroscopyAn increasing number of antibiotic residue problems in food have emerged around the world. We examine how SERS is used to identify antibiotic residues in chicken, focusing on doxycycline hydrochloride and tylosin.
Latest:
Spectral Sensing Using a Handheld NIR Module Based on a Fully Integrated Sensor ChipA novel approach to NIR spectral sensing, using a miniaturized fully-integrated multipixel array of resonant-cavity-enhanced InGaAs photodetectors, enables sensors with a millimeter-scale footprint and wafer-scale fabrication. This multipixel sensor does not measure the full spectrum, but rather a limited number of spectral regions with limited resolution (50–100 nm).
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Authenticity Identification of Panax notoginseng by Terahertz Spectroscopy Combined with LS-SVMIn this article, it is explored whether THz-TDS combined with LS-SVM can be used to effectively identify the authenticity of Panax notoginseng, a traditional Chinese medicine.
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Analysis of Infrared and Raman Imaging Data Using Alternating and Modified Alternating Least SquaresThis study explores the enhanced performance of modified alternating least squares (MALS) over alternating least squares (ALS) in analyzing infrared and Raman image spectral data, highlighting the stability and computational efficiency of MALS.
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How Pharmaceutical Innovation is Saving the WorldThe COVID-19 vaccine, and the speed at which it was developed, is the medical breakthrough of our lifetimes.
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Analysis of Elements in Snack Foods: A Closer Look at Pepperoni, Rice Noodles, Frozen Dinners, and PizzaSoftware tools for ICP-MS and ICP-OES can help analysts to simplify method setup and reduce the potential for errors.
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The Use of X-Ray Powder Diffraction (XRD) and Vibrational Spectroscopic Techniques in the Analysis of Suspect Pharmaceutical ProductsHere, we compare XRD and FT-IR for analysis of suspect counterfeit pharmaceuticals to determine how the techniques can be used in a complementary fashion.
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Real-Time Chemometric Analysis of Multicomponent Bioprocesses Using Raman SpectroscopyIn this study, a glycerol-fed, lab-scale E. coli bioprocess producing representative pharmaceutical compounds was monitored offline with a portable, high-sensitivity Raman spectrometer.
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Authenticity Identification of Panax notoginseng by Terahertz Spectroscopy Combined with LS-SVMIn this article, it is explored whether THz-TDS combined with LS-SVM can be used to effectively identify the authenticity of Panax notoginseng, a traditional Chinese medicine.
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Comparative Study of Heavy Metals Analysis in Mongolian Medicines Based on High Sensitivity X-ray Fluorescence Spectroscopy and ICP-MSIn this study, X-ray fluorescence (XRF) spectroscopy was used to analyze heavy metals in five traditional Mongolian medicines, and the results were compared to those obtained using ICP-MS.
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Analysis of Unlabeled Sibutramine in Dietary Supplements Using Surface-Enhanced Raman Spectroscopy (SERS) with Handheld DevicesThis article discusses how FT-IR and SERS is being used to detect counterfeit pharmaceutical drugs.
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Studying the Source of Raw Material and Glaze Formula of Sky Green “Ru-type Ware” and Ru Kuan Ware by EDXRFAs this study demonstrates, energy-dispersive X-ray fluorescence (EDXRF) and multivariate statistical analysis can be used to distinguish different classes of historical artifacts, such as ancient pottery—revealing insights about theirs origin and uses.
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Detection of Trace Tin(II) by Salicylfluoroketone Complex Fluorescence MethodA complex fluorescence method utilizing the Sn(II)-salicylfluorescein (SAF)-cetyltrimethylammonium bromide (CTMAB) system demonstrated effective detection of Sn(II) with a linear relationship between its concentration and fluorescence intensity, along with successful application in various sample matrices with high recovery rates.
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Fingerprinting of Mineral Medicine Natrii Sulfas by Fourier Transform Infrared SpectroscopyWe show how FT-IR may be used for quality control analysis of natrii sulfas, a transparent crystalline material used in natural medicine that primarily contains sodium sulfate decahydrate, crystallized from sulfate minerals.
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Simultaneous Detection of Nitrate and Nitrite Based on UV Absorption Spectroscopy and Machine LearningRegulations have been imposed to set legal limits of nitrate and nitrite in water worldwide. In this study, a highly accurate and optimized ultraviolet (UV) spectroscopy method is proposed to simultaneously monitor nitrate and nitrite for rapid determination and continuous monitoring in environmental water applications.
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Cold-Hot Nature Identification of Chinese Medicine Based on an Ultraviolet Chemical FingerprintA model has been developed to predict the “cold” or “hot” nature of Chinese medicines based on UV spectral data.
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Spectrophotometric and Chemometric Methods for Simultaneous Determination of Antazoline and Naphazoline in Pharmaceutical Eye DropsThis study applied principal component regression (PCR) and partial least squares (PLS) algorithms for the spectrophotometric analysis of a drug containing antazoline hydrochloride (AN) and naphazoline hydrochloride (NP) without chemical separation. Both methods showed high accuracy and precision, with results closely matching those from a reference HPLC method, and were successfully validated for analyzing commercial pharmaceutical products.
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Study on Estimating Total Nitrogen Content in Sugar Beet Leaves Under Drip Irrigation Based on Vis-NIR Hyperspectral Data and Chlorophyll ContentThe relationship between leaf nitrogen content (LNC) and hyperspectral remote sensing imagery (HYP) was determined to construct an estimation model of the LNC of drip-irrigated sugar beets, to enable real-time monitoring of sugar beet growth and nitrogen management in arid areas.
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Raman Spectroscopy: A Key Technique in Investigating Carbon-Based MaterialsThis article explains the key steps of using Raman technology to investigate carbon and carbon-based materials—such as carbon nanotubes, graphene, and carbon fibers and composites—as well as the process of analyzing the spectra.
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Automatic Coal-Rock Recognition by Laser-Induced Breakdown Spectroscopy Combined with an Artificial Neural NetworkAn artificial neural network was combined with LIBS to provide a rapid and accurate coal-rock recognition method for unmanned coal mining.
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Simultaneous Determination of 50 Elements in Geological Samples by ICP-MS Combined with ICP-OESA method combining inductively coupled plasma–mass spectrometry (ICP-MS) with inductively coupled plasma–optical emission spectrometry (ICP-OES) was developed for multielement determination of 50 species of major, minor, micro, and trace, rare earth, and rare elements in geological samples.
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Optimization of a Soil Particle Content Prediction Model Based on a Combined Spectral Index and Successive Projections Algorithm Using Vis-NIR SpectroscopyA rapid vis-NIR spectroscopy method for determining soil particle size and quality.
Latest:
Comparative Study of Heavy Metals Analysis in Mongolian Medicines Based on High Sensitivity X-ray Fluorescence Spectroscopy and ICP-MSIn this study, X-ray fluorescence (XRF) spectroscopy was used to analyze heavy metals in five traditional Mongolian medicines, and the results were compared to those obtained using ICP-MS.
